U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Mrps23 mitochondrial ribosomal protein S23 [ Mus musculus (house mouse) ]

    Gene ID: 64656, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Mrps23provided by MGI
    Official Full Name
    mitochondrial ribosomal protein S23provided by MGI
    Primary source
    MGI:MGI:1928138
    See related
    Ensembl:ENSMUSG00000023723 AllianceGenome:MGI:1928138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S23mt; Rpms23; MRP-S23; D11Bwg1153e
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Located in mitochondrion. Is expressed in several structures, including brain; early conceptus; genitourinary system; heart; and liver. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 46. Orthologous to human MRPS23 (mitochondrial ribosomal protein S23). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 29.9), CNS E14 (RPKM 18.7) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    11 C; 11 52.4 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (88084932..88102333)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88194106..88211507)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene vascular endothelial zinc finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87905511-87905664 Neighboring gene RIKEN cDNA 2210416O15 gene Neighboring gene CUE domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_30316 Neighboring gene STARR-positive B cell enhancer ABC_E8441 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:88047672-88047825 Neighboring gene STARR-positive B cell enhancer ABC_E7041 Neighboring gene predicted gene, 38534 Neighboring gene VISTA enhancer mm439 Neighboring gene predicted gene, 34366

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. Koc EC, et al. J Biol Chem, 2000 Oct 20. PMID 10938081
    2. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
    3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    4. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
    5. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • 2310047I09Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    small ribosomal subunit protein mS23
    Names
    28S ribosomal protein S23, mitochondrial

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291270.1 → NP_001278199.1  small ribosomal subunit protein mS23 isoform b

      See identical proteins and their annotated locations for NP_001278199.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5-terminal exon, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, and 4 encode the same isoform.
      Source sequence(s)
      AK014375, AL593853, AW121224
      Consensus CDS
      CCDS70279.1
      UniProtKB/TrEMBL
      Q3THH3, Q3TI14
      Conserved Domains (1) summary
      pfam10484
      Location:1 → 109
      MRP-S23; Mitochondrial ribosomal protein S23

    2. NM_001291271.1 → NP_001278200.1  small ribosomal subunit protein mS23 isoform b

      See identical proteins and their annotated locations for NP_001278200.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5'-terminal exon, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, and 4 encode the same isoform.
      Source sequence(s)
      AK014375, AL593853, AW121224, BY238199, BY794322
      Consensus CDS
      CCDS70279.1
      UniProtKB/TrEMBL
      Q3THH3, Q3TI14
      Conserved Domains (1) summary
      pfam10484
      Location:1 → 109
      MRP-S23; Mitochondrial ribosomal protein S23

    3. NM_001291272.1 → NP_001278201.1  small ribosomal subunit protein mS23 isoform b

      See identical proteins and their annotated locations for NP_001278201.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5'-terminal exon, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, and 4 encode the same isoform.
      Source sequence(s)
      AK014375, AW121224, BY238199, BY794322
      Consensus CDS
      CCDS70279.1
      UniProtKB/TrEMBL
      Q3THH3, Q3TI14
      Related
      ENSMUSP00000113512.2, ENSMUST00000118784.8
      Conserved Domains (1) summary
      pfam10484
      Location:1 → 109
      MRP-S23; Mitochondrial ribosomal protein S23

    4. NM_001291273.1 → NP_001278202.1  small ribosomal subunit protein mS23 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
      Source sequence(s)
      AK014375, AW121224, BY238199
      UniProtKB/TrEMBL
      F7ARZ1
      Related
      ENSMUSP00000122963.2, ENSMUST00000144070.3
      Conserved Domains (1) summary
      cl24037
      Location:2 → 73
      MRP-S25; Mitochondrial ribosomal protein S25

    5. NM_024174.6 → NP_077136.2  small ribosomal subunit protein mS23 isoform a

      See identical proteins and their annotated locations for NP_077136.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK014375, AW121224, BY238199
      Consensus CDS
      CCDS25227.1
      UniProtKB/Swiss-Prot
      Q8VE22, Q9CXH1
      UniProtKB/TrEMBL
      Q3THH3
      Related
      ENSMUSP00000024486.8, ENSMUST00000024486.14
      Conserved Domains (1) summary
      pfam10484
      Location:2 → 128
      MRP-S23; Mitochondrial ribosomal protein S23

    RNA

    1. NR_111902.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site in the 5'-terminal exon, and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK014375, AW121224, BY238199, BY794322

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      88084932..88102333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE22.1 GenPept UniProtKB/Swiss-Prot:Q8VE22

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous