Asic1 acid-sensing ion channel 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asic1provided by MGI
Official Full Name: acid-sensing ion channel 1provided by MGI
Primary source: MGI:MGI:1194915
See related: Ensembl:ENSMUSG00000023017 AllianceGenome:MGI:1194915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ASIC; Accn2; BNaC2; ASIC1a; ASIC1b; B530003N02Rik
Summary: Enables acid-sensing ion channel activity and ion gated channel activity. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and response to amphetamine. Located in synapse. Is integral component of plasma membrane. Is expressed in several structures, including brain. Orthologous to human ASIC1 (acid sensing ion channel subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 11.2), CNS E18 (RPKM 10.4) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 56.13 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (99568090..99599011)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (99670197..99701130)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of ASIC1a Improves Behavioral Recovery after Stroke.
Title: Inhibition of ASIC1a Improves Behavioral Recovery after Stroke.
ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice.
Title: ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice.
Acid-sensing ion channel 1a exacerbates renal ischemia-reperfusion injury through the NF-kappaB/NLRP3 inflammasome pathway.
Title: Acid-sensing ion channel 1a exacerbates renal ischemia-reperfusion injury through the NF-κB/NLRP3 inflammasome pathway.
Acid-sensitive ion channel 1a regulates TNF-alpha expression in LPS-induced acute lung injury via ERS-CHOP-C/EBPalpha signaling pathway.
Title: Acid-sensitive ion channel 1a regulates TNF-α expression in LPS-induced acute lung injury via ERS-CHOP-C/EBPα signaling pathway.
Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation.
Title: Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation.
Knockdown of Acid-sensing Ion Channel 1a in the PVN Promotes Metabolic Disturbances in Male Mice.
Title: Knockdown of Acid-sensing Ion Channel 1a in the PVN Promotes Metabolic Disturbances in Male Mice.
Acid-sensing ion channel 1a regulates the specificity of reconsolidation of conditioned threat responses.
Title: Acid-sensing ion channel 1a regulates the specificity of reconsolidation of conditioned threat responses.
Activation of acid-sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation.
Title: Activation of acid-sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation.
C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3.
Title: C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3.
Acid-sensing ion channel 1 contributes to pulmonary arterial smooth muscle cell depolarization following hypoxic pulmonary hypertension.
Title: Acid-sensing ion channel 1 contributes to pulmonary arterial smooth muscle cell depolarization following hypoxic pulmonary hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (109)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI843610 (e-PCR)
- UniSTS:165964

AU047966 (e-PCR)
- UniSTS:110005

D15Mit77 (e-PCR), detects polymorphism
- UniSTS:127699

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables inorganic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion-gated channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion-gated channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pH-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables pH-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables pH-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to pH	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inorganic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic cation transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to acidic pH	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to acidic pH	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sour taste	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acid-sensing ion channel 1

Names: acid-sensing (proton-gated) ion channel 1; amiloride-sensitive cation channel 2, neuronal; brain sodium channel 2; degenerin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289791.2 → NP_001276720.1 acid-sensing ion channel 1 isoform 2

See identical proteins and their annotated locations for NP_001276720.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. It encodes isoform 2 which has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AC134548

Consensus CDS

CCDS88841.1

UniProtKB/Swiss-Prot

Q6NXK8

Related

ENSMUSP00000154379.2, ENSMUST00000228185.2

Conserved Domains (1) summary

cl02990
Location:63 → 541

ASC; Amiloride-sensitive sodium channel
NM_009597.2 → NP_033727.1 acid-sensing ion channel 1 isoform 1

See identical proteins and their annotated locations for NP_033727.1

Status: VALIDATED

Source sequence(s)

AI850572, BC067025, CB527867

Consensus CDS

CCDS27826.1

UniProtKB/Swiss-Prot

Q50K97, Q6NXK8

Related

ENSMUSP00000023758.8, ENSMUST00000023758.9

Conserved Domains (1) summary

TIGR00859
Location:19 → 508

ENaC; sodium channel transporter