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    Glycam1 glycosylation dependent cell adhesion molecule 1 [ Mus musculus (house mouse) ]

    Gene ID: 14663, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Glycam1provided by MGI
    Official Full Name
    glycosylation dependent cell adhesion molecule 1provided by MGI
    Primary source
    MGI:MGI:95759
    See related
    Ensembl:ENSMUSG00000022491 AllianceGenome:MGI:95759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MC26; Sgp50; glyCAM-1
    Summary
    Enables cell adhesion molecule binding activity and sulfate binding activity. Acts upstream of or within response to bacterium. Located in extracellular region. Is expressed in central nervous system and retina. Orthologous to human GLYCAM1 (glycosylation dependent cell adhesion molecule 1 (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward mammary gland adult (RPKM 204.7) See more
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    Genomic context

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    Location:
    15 F3; 15 59.03 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (103471186..103473508, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (103562759..103565081, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39886 Neighboring gene phosphodiesterase 1B, Ca2+-calmodulin dependent Neighboring gene STARR-seq mESC enhancer starr_39888 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 1A Neighboring gene STARR-seq mESC enhancer starr_39890 Neighboring gene hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit pseudogene Neighboring gene STARR-seq mESC enhancer starr_39891 Neighboring gene STARR-seq mESC enhancer starr_39892 Neighboring gene STARR-seq mESC enhancer starr_39893 Neighboring gene predicted gene, 53235

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma. Williams PA, et al. J Neuroinflammation, 2017 Apr 26. PMID 28446179, Free PMC Article
    2. Two tandemly linked interferon-gamma-activated sequence elements in the promoter of glycosylation-dependent cell adhesion molecule 1 gene synergistically respond to prolactin in mouse mammary epithelial cells. Hou Z, et al. Mol Endocrinol, 2003 Oct. PMID 12869589
    3. Increased plasma GlyCAM-1, a mouse L-selectin ligand, in response to an inflammatory stimulus. Suguri T, et al. J Leukoc Biol, 1996 Nov. PMID 8929549
    4. Expression of the mC26 gene encoding GlyCAM-1 in the lactating mouse mammary gland. Nishimura T, et al. J Biochem, 1993 Oct. PMID 8276769
    5. 6'-sulfated sialyl Lewis x is a major capping group of GlyCAM-1. Hemmerich S, et al. Biochemistry, 1994 Apr 26. PMID 8161542

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GlyCam1 levels modulate immune cell entry from the vasculature into neural tissues.
      Title: GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma.
    2. analyses of the GlyCAM 1 promoter demonstrated that the two tandemly linked Stat5 binding sites [interferon-gamma-activated sequence 1 and -2 (GAS1 and GAS2)] in the proximal promoter region were crucial and synergistically responded to PRL.
      Title: Two tandemly linked interferon-gamma-activated sequence elements in the promoter of glycosylation-dependent cell adhesion molecule 1 gene synergistically respond to prolactin in mouse mammary epithelial cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sulfate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycosylation-dependent cell adhesion molecule 1
    Names
    GlyCAM 1
    Sele ligand
    endothelial ligand FOR L-selectin
    sulfated 50 kDa glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289587.1 → NP_001276516.1  glycosylation-dependent cell adhesion molecule 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001276516.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC108858, BE947771
      Consensus CDS
      CCDS88862.1
      UniProtKB/TrEMBL
      A0A2I3BPT0
      Related
      ENSMUSP00000153908.2, ENSMUST00000228895.2
      Conserved Domains (1) summary
      pfam05242
      Location:20 → 108
      GLYCAM-1; Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1)

    2. NM_008134.3 → NP_032160.1  glycosylation-dependent cell adhesion molecule 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_032160.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The encoded isoform (1) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC108858, AK021358, BE947771
      Consensus CDS
      CCDS27905.1
      UniProtKB/Swiss-Prot
      A6H6D0, Q02596
      UniProtKB/TrEMBL
      B7ZNZ9
      Related
      ENSMUSP00000023134.4, ENSMUST00000023134.5
      Conserved Domains (1) summary
      pfam05242
      Location:20 → 151
      GLYCAM-1; Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      103471186..103473508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02596.1 GenPept UniProtKB/Swiss-Prot:Q02596

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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