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    Wbp2nl WBP2 N-terminal like [ Mus musculus (house mouse) ]

    Gene ID: 74716, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Wbp2nlprovided by MGI
    Official Full Name
    WBP2 N-terminal likeprovided by MGI
    Primary source
    MGI:MGI:1921966
    See related
    Ensembl:ENSMUSG00000022455 AllianceGenome:MGI:1921966
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAWP; 4930521I23Rik
    Summary
    Predicted to enable WW domain binding activity; chromatin DNA binding activity; and transcription coactivator activity. Predicted to be involved in egg activation; male pronucleus assembly; and positive regulation of transcription, DNA-templated. Predicted to act upstream of or within female pronucleus assembly. Predicted to be located in perinuclear theca; sperm flagellum; and sperm head. Predicted to be active in nucleus. Orthologous to human WBP2NL (WBP2 N-terminal like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 60.3) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 E1; 15 38.56 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82183126..82198848)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82298925..82314647)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 45 Neighboring gene predicted gene, 52180 Neighboring gene septin 3 Neighboring gene STARR-seq mESC enhancer starr_39292 Neighboring gene N-acetyl galactosaminidase, alpha Neighboring gene PH domain containing endocytic trafficking adaptor 2 Neighboring gene nuclear encoded rRNA 5S 41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sperm postacrosomal WW domain-binding protein is not required for mouse egg activation. Satouh Y, et al. Biol Reprod, 2015 Oct. PMID 26377222
    2. Sperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca2+ release in mouse oocytes. Nomikos M, et al. Mol Hum Reprod, 2014 Oct. PMID 25057041, Free PMC Article
    3. Sperm-derived WW domain-binding protein, PAWP, elicits calcium oscillations and oocyte activation in humans and mice. Aarabi M, et al. FASEB J, 2014 Oct. PMID 24970390
    4. Expression analysis of PAWP during mouse embryonic stem cell-based spermatogenesis in vitro. Nourashrafeddin S, et al. In Vitro Cell Dev Biol Anim, 2014. PMID 24381051
    5. The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport. Wu AT, et al. Dev Biol, 2007 Dec 15. PMID 17988661

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAWP does not play an essential role in mouse fertilization
      Title: Sperm postacrosomal WW domain-binding protein is not required for mouse egg activation.
    2. The data suggest that sperm-derived PAWP is not involved in triggering Ca(2+) oscillations at fertilization in mammalian oocytes.
      Title: Sperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca2+ release in mouse oocytes.
    3. These results indicate that PAWP plays a role in spermatogenesis and germ cell development. Moreover, we suggest PAWP as one of the markers that could be looked in ESC studies as a confirmed testis-specific gene
      Title: Expression analysis of PAWP during mouse embryonic stem cell-based spermatogenesis in vitro.
    4. The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport
      Title: The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables WW domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in egg activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within female pronucleus assembly ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in male pronucleus assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear theca ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm head ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    postacrosomal sheath WW domain-binding protein
    Names
    WW domain-binding protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029066.1 → NP_083342.1  postacrosomal sheath WW domain-binding protein

      See identical proteins and their annotated locations for NP_083342.1

      Status: PROVISIONAL

      Source sequence(s)
      BC119520
      Consensus CDS
      CCDS37158.1
      UniProtKB/Swiss-Prot
      Q9D529
      Related
      ENSMUSP00000023089.4, ENSMUST00000023089.5
      Conserved Domains (3) summary
      cd13214
      Location:31 → 129
      PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam10349
      Location:103 → 225
      WWbp; WW-domain ligand protein
      cl23807
      Location:254 → 327
      WWbp; WW-domain ligand protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      82183126..82198848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316772.2 → XP_017172261.1  postacrosomal sheath WW domain-binding protein isoform X1

      Conserved Domains (2) summary
      PTZ00436
      Location:182 → 345
      PTZ00436; 60S ribosomal protein L19-like protein; Provisional
      cd13214
      Location:48 → 146
      PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D529.1 GenPept UniProtKB/Swiss-Prot:Q9D529

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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