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    Spata13 spermatogenesis associated 13 [ Mus musculus (house mouse) ]

    Gene ID: 219140, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Spata13provided by MGI
    Official Full Name
    spermatogenesis associated 13provided by MGI
    Primary source
    MGI:MGI:104838
    See related
    Ensembl:ENSMUSG00000021990 AllianceGenome:MGI:104838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    asef2; ESTM11; mFLJ00298
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and identical protein binding activity. Predicted to be involved in cell migration; plasma membrane bounded cell projection assembly; and regulation of cell migration. Predicted to be located in several cellular components, including filopodium; lamellipodium; and ruffle membrane. Is expressed in brain; thymus primordium; and vertebral cartilage condensation. Orthologous to human SPATA13 (spermatogenesis associated 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.9), adrenal adult (RPKM 5.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 D1; 14 31.77 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (60722617..61002005)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (60485168..60764556)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene APC membrane recruitment 2 Neighboring gene peptidylprolyl isomerase A pseudogene 14_696.1 Neighboring gene STARR-positive B cell enhancer ABC_E11785 Neighboring gene VISTA enhancer mm1122 Neighboring gene STARR-positive B cell enhancer ABC_E11571 Neighboring gene predicted gene, 41166 Neighboring gene STARR-seq mESC enhancer starr_36860 Neighboring gene predicted gene, 41165 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61328022-61328292 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61351140-61351293 Neighboring gene STARR-seq mESC enhancer starr_36862 Neighboring gene STARR-positive B cell enhancer mm9_chr14:61357423-61357724 Neighboring gene STARR-seq mESC enhancer starr_36864 Neighboring gene predicted gene, 34997 Neighboring gene C1q and tumor necrosis factor related protein 9 Neighboring gene mitochondrial intermediate peptidase, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The guanine nucleotide exchange factor, Spata13, influences social behaviour and nocturnal activity. Bourbia N, et al. Mamm Genome, 2019 Apr. PMID 31020388, Free PMC Article
    2. The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. Kawasaki Y, et al. EMBO Rep, 2009 Dec. PMID 19893577, Free PMC Article
    3. Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury. Chaboub LS, et al. J Neurosci, 2016 Nov 23. PMID 27881777, Free PMC Article
    4. Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain. Yoshizawa M, et al. Gene Expr Patterns, 2003 Jun. PMID 12799088
    5. A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex. Najas S, et al. Development, 2020 Jul 13. PMID 32541003

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spata13 modulates social hierarchy in both male and female mice in addition to affecting voluntary activity in females.
      Title: The guanine nucleotide exchange factor, Spata13, influences social behaviour and nocturnal activity.
    2. Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. [Asef2, mouse]
      Title: The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00298

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    spermatogenesis-associated protein 13
    Names
    APC-stimulated guanine nucleotide exchange factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033272.3 → NP_001028444.1  spermatogenesis-associated protein 13 isoform 1

      See identical proteins and their annotated locations for NP_001028444.1

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835
      Consensus CDS
      CCDS49516.1
      UniProtKB/TrEMBL
      B9EHV2, E9Q3I3
      Related
      ENSMUSP00000022566.8, ENSMUST00000022566.14
      Conserved Domains (4) summary
      cd11973
      Location:726 → 797
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:836 → 1015
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:200 → 446
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:1020 → 1158
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

    2. NM_001310594.2 → NP_001297523.1  spermatogenesis-associated protein 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835
      Consensus CDS
      CCDS79328.1
      UniProtKB/Swiss-Prot
      Q3TZ09, Q5DU57
      UniProtKB/TrEMBL
      B7ZNJ6, E0CYU0
      Related
      ENSMUSP00000123888.2, ENSMUST00000162945.2
      Conserved Domains (4) summary
      cd11973
      Location:56 → 127
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      cd01224
      Location:350 → 488
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:378 → 477
      PH; PH domain
      pfam00621
      Location:166 → 345
      RhoGEF; RhoGEF domain

    3. NM_001404949.1 → NP_001391878.1  spermatogenesis-associated protein 13 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835, AC164429

    4. NM_001404950.1 → NP_001391879.1  spermatogenesis-associated protein 13 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835

    5. NM_001404951.1 → NP_001391880.1  spermatogenesis-associated protein 13 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835

    6. NM_001404952.1 → NP_001391881.1  spermatogenesis-associated protein 13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835

    7. NM_001404953.1 → NP_001391882.1  spermatogenesis-associated protein 13 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835

    8. NM_001404954.1 → NP_001391883.1  spermatogenesis-associated protein 13 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835

    9. NM_001404964.1 → NP_001391893.1  spermatogenesis-associated protein 13 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114000, AC151835
      UniProtKB/TrEMBL
      E9Q3I3
      Related
      ENSMUSP00000123928.2, ENSMUST00000160973.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      60722617..61002005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247763.1 → XP_030103623.1  spermatogenesis-associated protein 13 isoform X3

      UniProtKB/TrEMBL
      B9EHV2, E9Q3I3
      Conserved Domains (4) summary
      cd11973
      Location:726 → 797
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:836 → 1015
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:200 → 446
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:1020 → 1158
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

    2. XM_017315974.3 → XP_017171463.1  spermatogenesis-associated protein 13 isoform X8

      Conserved Domains (1) summary
      PHA03247
      Location:251 → 497
      PHA03247; large tegument protein UL36; Provisional

    3. XM_036158561.1 → XP_036014454.1  spermatogenesis-associated protein 13 isoform X1

      UniProtKB/TrEMBL
      B9EHV2
      Conserved Domains (4) summary
      cd11973
      Location:777 → 848
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:887 → 1066
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:251 → 497
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:1071 → 1209
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

    4. XM_036158562.1 → XP_036014455.1  spermatogenesis-associated protein 13 isoform X2

      UniProtKB/TrEMBL
      B9EHV2
      Conserved Domains (4) summary
      cd11973
      Location:767 → 838
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:877 → 1056
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:251 → 500
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:1061 → 1199
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

    5. XM_036158565.1 → XP_036014458.1  spermatogenesis-associated protein 13 isoform X5

      UniProtKB/TrEMBL
      B9EHV2
      Conserved Domains (4) summary
      cd11973
      Location:655 → 726
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:765 → 944
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:251 → 603
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:949 → 1087
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

    6. XM_011245026.3 → XP_011243328.1  spermatogenesis-associated protein 13 isoform X3

      See identical proteins and their annotated locations for XP_011243328.1

      UniProtKB/TrEMBL
      B9EHV2, E9Q3I3
      Conserved Domains (4) summary
      cd11973
      Location:726 → 797
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:836 → 1015
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:200 → 446
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:1020 → 1158
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

    7. XM_030247762.1 → XP_030103622.1  spermatogenesis-associated protein 13 isoform X3

      UniProtKB/TrEMBL
      B9EHV2, E9Q3I3
      Conserved Domains (4) summary
      cd11973
      Location:726 → 797
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:836 → 1015
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:200 → 446
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:1020 → 1158
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

    8. XM_030247764.1 → XP_030103624.1  spermatogenesis-associated protein 13 isoform X3

      UniProtKB/TrEMBL
      B9EHV2, E9Q3I3
      Conserved Domains (4) summary
      cd11973
      Location:726 → 797
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:836 → 1015
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:200 → 446
      PHA03247; large tegument protein UL36; Provisional
      cd01224
      Location:1020 → 1158
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

    9. XM_006518870.3 → XP_006518933.1  spermatogenesis-associated protein 13 isoform X7

      UniProtKB/Swiss-Prot
      Q3TZ09, Q5DU57
      Conserved Domains (3) summary
      cd11973
      Location:231 → 302
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      smart00325
      Location:341 → 520
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01224
      Location:525 → 663
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DU57.2 GenPept UniProtKB/Swiss-Prot:Q5DU57

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