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    Gfm2 G elongation factor, mitochondrial 2 [ Mus musculus (house mouse) ]

    Gene ID: 320806, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gfm2provided by MGI
    Official Full Name
    G elongation factor, mitochondrial 2provided by MGI
    Primary source
    MGI:MGI:2444783
    See related
    Ensembl:ENSMUSG00000021666 AllianceGenome:MGI:2444783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EFG2; MST027; RRF2mt; EF-G2mt; 6530419G12Rik; A930009M04Rik
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in mitochondrial translation and ribosome disassembly. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in brain; dorsal root ganglion; liver lobe; spinal cord; and thymus primordium. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 39. Orthologous to human GFM2 (GTP dependent ribosome recycling factor mitochondrial 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 8.7), kidney adult (RPKM 6.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 D1; 13 50.66 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (97274445..97317710)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (97137933..97181202)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 169, member A Neighboring gene proteolipid protein 2, retrotransposed Neighboring gene STARR-positive B cell enhancer ABC_E3094 Neighboring gene NSA2 ribosome biogenesis homolog Neighboring gene hexosaminidase B Neighboring gene STARR-seq mESC enhancer starr_35367 Neighboring gene STARR-seq mESC enhancer starr_35370 Neighboring gene ectodermal-neural cortex 1 Neighboring gene STARR-seq mESC enhancer starr_35377 Neighboring gene predicted gene, 33390

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gut colonization by Bacteroides requires translation by an EF-G paralog lacking GTPase activity. Han W, et al. EMBO J, 2023 Jan 16. PMID 36472247, Free PMC Article
    2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gut colonization by Bacteroides requires translation by an EF-G paralog lacking GTPase activity.
      Title: Gut colonization by Bacteroides requires translation by an EF-G paralog lacking GTPase activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    ribosome-releasing factor 2, mitochondrial
    NP_001139515.1
    NP_001258392.1
    NP_001258393.1
    NP_001258394.1
    NP_796240.3
    XP_006517752.1
    XP_006517753.1
    XP_006517754.1
    XP_030103160.1
    XP_030103161.1
    XP_030103162.1
    XP_030103163.1
    XP_036013965.1
    XP_036013966.1
    XP_036013967.1
    XP_036013968.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146043.2 → NP_001139515.1  ribosome-releasing factor 2, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001139515.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a different terminal exon for its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154620, AI666524, AK044371, AK161797
      Consensus CDS
      CCDS49338.1
      UniProtKB/TrEMBL
      E9Q7N5, Q3TSU6
      Related
      ENSMUSP00000125088.2, ENSMUST00000161825.8
      Conserved Domains (1) summary
      PRK13351
      Location:64 → 732
      PRK13351; elongation factor G-like protein

    2. NM_001271463.1 → NP_001258392.1  ribosome-releasing factor 2, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001258392.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC154620, AK035819, AK044371
      Consensus CDS
      CCDS26708.2
      UniProtKB/Swiss-Prot
      B2RR55, Q8BXS5, Q8R2Q4
      UniProtKB/TrEMBL
      Q3TSU6
      Conserved Domains (1) summary
      PRK12739
      Location:66 → 774
      PRK12739; elongation factor G; Reviewed

    3. NM_001271464.1 → NP_001258393.1  ribosome-releasing factor 2, mitochondrial isoform 3

      See identical proteins and their annotated locations for NP_001258393.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and lacks an in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC154620, AK044371
      Consensus CDS
      CCDS70490.1
      UniProtKB/TrEMBL
      Q3TSU6
      Related
      ENSMUSP00000048373.7, ENSMUST00000042084.13
      Conserved Domains (1) summary
      PRK12739
      Location:66 → 747
      PRK12739; elongation factor G; Reviewed

    4. NM_001271465.1 → NP_001258394.1  ribosome-releasing factor 2, mitochondrial isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC154620, AK035819, AK044371
      Consensus CDS
      CCDS70491.1
      UniProtKB/TrEMBL
      Q3TSU6
      Related
      ENSMUSP00000022170.8, ENSMUST00000022170.8
      Conserved Domains (1) summary
      PRK13351
      Location:62 → 757
      PRK13351; elongation factor G-like protein

    5. NM_177266.5 → NP_796240.3  ribosome-releasing factor 2, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_796240.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC154620, AK035819, AK044371
      Consensus CDS
      CCDS26708.2
      UniProtKB/Swiss-Prot
      B2RR55, Q8BXS5, Q8R2Q4
      UniProtKB/TrEMBL
      Q3TSU6
      Related
      ENSMUSP00000125656.2, ENSMUST00000161639.8
      Conserved Domains (1) summary
      PRK12739
      Location:66 → 774
      PRK12739; elongation factor G; Reviewed

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      97274445..97317710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517690.5 → XP_006517753.1  ribosome-releasing factor 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006517753.1

      UniProtKB/Swiss-Prot
      B2RR55, Q8BXS5, Q8R2Q4
      UniProtKB/TrEMBL
      Q3TSU6
      Conserved Domains (1) summary
      PRK12739
      Location:66 → 774
      PRK12739; elongation factor G; Reviewed

    2. XM_036158074.1 → XP_036013967.1  ribosome-releasing factor 2, mitochondrial isoform X2

      UniProtKB/TrEMBL
      Q3TSU6
      Conserved Domains (1) summary
      PRK12739
      Location:66 → 747
      PRK12739; elongation factor G; Reviewed

    3. XM_006517691.5 → XP_006517754.1  ribosome-releasing factor 2, mitochondrial isoform X3

      See identical proteins and their annotated locations for XP_006517754.1

      UniProtKB/TrEMBL
      E9Q7N5, Q3TSU6
      Conserved Domains (1) summary
      PRK13351
      Location:64 → 732
      PRK13351; elongation factor G-like protein

    4. XM_036158073.1 → XP_036013966.1  ribosome-releasing factor 2, mitochondrial isoform X2

      UniProtKB/TrEMBL
      Q3TSU6
      Conserved Domains (1) summary
      PRK12739
      Location:66 → 747
      PRK12739; elongation factor G; Reviewed

    5. XM_030247303.2 → XP_030103163.1  ribosome-releasing factor 2, mitochondrial isoform X4

      Conserved Domains (1) summary
      PRK12740
      Location:1 → 573
      PRK12740; elongation factor G-like protein EF-G2

    6. XM_030247300.2 → XP_030103160.1  ribosome-releasing factor 2, mitochondrial isoform X4

      Conserved Domains (1) summary
      PRK12740
      Location:1 → 573
      PRK12740; elongation factor G-like protein EF-G2

    7. XM_036158075.1 → XP_036013968.1  ribosome-releasing factor 2, mitochondrial isoform X5

      Conserved Domains (1) summary
      PRK12740
      Location:1 → 546
      PRK12740; elongation factor G-like protein EF-G2

    8. XM_030247302.2 → XP_030103162.1  ribosome-releasing factor 2, mitochondrial isoform X4

      Conserved Domains (1) summary
      PRK12740
      Location:1 → 573
      PRK12740; elongation factor G-like protein EF-G2

    9. XM_006517689.5 → XP_006517752.1  ribosome-releasing factor 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006517752.1

      UniProtKB/Swiss-Prot
      B2RR55, Q8BXS5, Q8R2Q4
      UniProtKB/TrEMBL
      Q3TSU6
      Conserved Domains (1) summary
      PRK12739
      Location:66 → 774
      PRK12739; elongation factor G; Reviewed

    10. XM_030247301.2 → XP_030103161.1  ribosome-releasing factor 2, mitochondrial isoform X4

      Conserved Domains (1) summary
      PRK12740
      Location:1 → 573
      PRK12740; elongation factor G-like protein EF-G2

    11. XM_036158072.1 → XP_036013965.1  ribosome-releasing factor 2, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      B2RR55, Q8BXS5, Q8R2Q4
      UniProtKB/TrEMBL
      Q3TSU6
      Conserved Domains (1) summary
      PRK12739
      Location:66 → 774
      PRK12739; elongation factor G; Reviewed

    RNA

    1. XR_004938030.1 RNA Sequence

    2. XR_004938031.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2Q4.2 GenPept UniProtKB/Swiss-Prot:Q8R2Q4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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