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    Lect2 leukocyte cell-derived chemotaxin 2 [ Mus musculus (house mouse) ]

    Gene ID: 16841, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Lect2provided by MGI
    Official Full Name
    leukocyte cell-derived chemotaxin 2provided by MGI
    Primary source
    MGI:MGI:1278342
    See related
    Ensembl:ENSMUSG00000021539 AllianceGenome:MGI:1278342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables identical protein binding activity. Acts upstream of or within negative regulation of Wnt signaling pathway. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Is expressed in liver lobe; lung; and neural retina. Orthologous to human LECT2 (leukocyte cell derived chemotaxin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 18.2), liver E14 (RPKM 7.9) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 B1; 13 30.08 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (56676772..56696373, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (56529734..56548559, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 48 Neighboring gene interleukin 9 Neighboring gene STARR-positive B cell enhancer mm9_chr13:56623558-56623859 Neighboring gene F-box and leucine-rich repeat protein 21 Neighboring gene RIKEN cDNA 2010203P06 gene Neighboring gene STARR-seq mESC enhancer starr_34649 Neighboring gene transforming growth factor, beta induced

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Liver infiltration of multiple immune cells during the process of acute liver injury and repair. Xie Y, et al. World J Gastroenterol, 2022 Dec 14. PMID 36569272, Free PMC Article
    2. Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET. Shirasaki T, et al. Nat Commun, 2022 Jun 8. PMID 35676290, Free PMC Article
    3. LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH. Takata N, et al. Sci Rep, 2021 Jan 12. PMID 33436955, Free PMC Article
    4. Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice. Chikamoto K, et al. Biochem Biophys Res Commun, 2016 Sep 23. PMID 27562717
    5. Possible role of LECT2 as an intrinsic regulatory factor in SEA-induced toxicity in d-galactosamine-sensitized mice. Dang MH, et al. Clin Immunol, 2010 Dec. PMID 20805039

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LECT2 modulates dendritic cell function after Helicobacter pylori infection via the CD209a receptor.
      Title: LECT2 modulates dendritic cell function after Helicobacter pylori infection via the CD209a receptor.
    2. Liver infiltration of multiple immune cells during the process of acute liver injury and repair.
      Title: Liver infiltration of multiple immune cells during the process of acute liver injury and repair.
    3. Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET.
      Title: Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET.
    4. LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH.
      Title: LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH.
    5. Leukocyte cell-derived chemotaxin 2 promotes the development of nonalcoholic fatty liver disease through STAT-1 pathway in mice.
      Title: Leukocyte cell-derived chemotaxin 2 promotes the development of nonalcoholic fatty liver disease through STAT-1 pathway in mice.
    6. This study demonstrates the rapid response of LECT2 preceding body weight alterations during weight cycling in mice.
      Title: Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice.
    7. We found that treatment with LECT2 enhanced H. pylori killing and nitric oxide production in macrophages. In addition, DNA-binding activity and nuclear translocation of p65 were up-regulated by LECT2 treatment
      Title: LECT2 association with macrophage-mediated killing of Helicobacter pylori by activating NF-κB and nitric oxide production.
    8. LECT2 is regulated by beta-catenin in HCC in both mice and men, but serum LECT2 reflects beta-catenin activity only in mice. Serum LECT2 could be a potential biomarker of HCC in patients.
      Title: Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma.
    9. LECT2 improves protective immunity in bacterial sepsis, possibly as a result of enhanced macrophages functions via the CD209a receptor.
      Title: LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor.
    10. Zinc stabilizes the LECT2 structure.
      Title: Leukocyte cell-derived chemotaxin 2 is a zinc-binding protein.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte cell-derived chemotaxin-2
    Names
    LECT-2
    chM-II
    chondromodulin II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010702.2 → NP_034832.2  leukocyte cell-derived chemotaxin-2 precursor

      See identical proteins and their annotated locations for NP_034832.2

      Status: VALIDATED

      Source sequence(s)
      AC132901, AI173435, AK131971
      Consensus CDS
      CCDS26564.1
      UniProtKB/Swiss-Prot
      O88803, O88804, Q3V287, Q8K181, Q9QWN3, Q9Z337
      UniProtKB/TrEMBL
      A0A0R4J0R8
      Related
      ENSMUSP00000060495.5, ENSMUST00000062806.6
      Conserved Domains (1) summary
      pfam01551
      Location:53 → 147
      Peptidase_M23; Peptidase family M23

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      56676772..56696373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157879.1 → XP_036013772.1  leukocyte cell-derived chemotaxin-2 isoform X1

      Conserved Domains (1) summary
      pfam01551
      Location:51 → 83
      Peptidase_M23; Peptidase family M23
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88803.1 GenPept UniProtKB/Swiss-Prot:O88803

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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