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    Cetn3 centrin 3 [ Mus musculus (house mouse) ]

    Gene ID: 12626, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cetn3provided by MGI
    Official Full Name
    centrin 3provided by MGI
    Primary source
    MGI:MGI:1097706
    See related
    Ensembl:ENSMUSG00000021537 AllianceGenome:MGI:1097706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MmCEN3
    Summary
    Enables G-protein beta/gamma-subunit complex binding activity and microtubule binding activity. Predicted to act upstream of or within cell division; mRNA transport; and protein transport. Located in centriole; ciliary basal body; and photoreceptor connecting cilium. Is expressed in several structures, including alimentary system; musculoskeletal system; nervous system; sensory organ; and vibrissa. Orthologous to human CETN3 (centrin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 18.1), CNS E11.5 (RPKM 17.0) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cetn3 in Genome Data Viewer
    Location:
    13 C3; 13 43.68 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (81928201..81945274)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (81780636..81797155)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35131 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide G Neighboring gene STARR-positive B cell enhancer ABC_E11550 Neighboring gene metallo-beta-lactamase domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_35132 Neighboring gene STARR-positive B cell enhancer ABC_E604 Neighboring gene STARR-positive B cell enhancer ABC_E3088 Neighboring gene STARR-positive B cell enhancer ABC_E7258 Neighboring gene STARR-seq mESC enhancer starr_35135 Neighboring gene STARR-seq mESC enhancer starr_35136 Neighboring gene predicted gene, 32836 Neighboring gene STARR-seq mESC enhancer starr_35138 Neighboring gene predicted gene, 41008

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of both centrin 2 (CETN2) and CETN3 destabilizes the distal connecting cilium of mouse photoreceptors. Ying G, et al. J Biol Chem, 2019 Mar 15. PMID 30647131, Free PMC Article
    2. Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene. Middendorp S, et al. Proc Natl Acad Sci U S A, 1997 Aug 19. PMID 9256449, Free PMC Article
    3. Centrin4p, a novel mammalian centrin specifically expressed in ciliated cells. Gavet O, et al. Mol Biol Cell, 2003 May. PMID 12802058, Free PMC Article
    4. PRCD is concentrated at the base of photoreceptor outer segments and is involved in outer segment disc formation. Allon G, et al. Hum Mol Genet, 2019 Dec 15. PMID 31628458
    5. Light-dependent CK2-mediated phosphorylation of centrins regulates complex formation with visual G-protein. Trojan P, et al. Biochim Biophys Acta, 2008 Jun. PMID 18269917

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein beta/gamma-subunit complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor connecting cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription export complex 2 ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007684.4 → NP_031710.1  centrin-3

      See identical proteins and their annotated locations for NP_031710.1

      Status: VALIDATED

      Source sequence(s)
      AI851499, AK006891, BY103593
      Consensus CDS
      CCDS26663.1
      UniProtKB/Swiss-Prot
      O35648
      UniProtKB/TrEMBL
      Q545L8, Q9CYN1, Q9D046
      Related
      ENSMUSP00000022009.9, ENSMUST00000022009.10
      Conserved Domains (1) summary
      PTZ00183
      Location:15 → 166
      PTZ00183; centrin; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      81928201..81945274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517074.5 → XP_006517137.1  centrin-3 isoform X1

      UniProtKB/TrEMBL
      Q9CYN1
      Conserved Domains (1) summary
      PTZ00183
      Location:15 → 157
      PTZ00183; centrin; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35648.1 GenPept UniProtKB/Swiss-Prot:O35648

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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