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    Ssr1 signal sequence receptor, alpha [ Mus musculus (house mouse) ]

    Gene ID: 107513, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ssr1provided by MGI
    Official Full Name
    signal sequence receptor, alphaprovided by MGI
    Primary source
    MGI:MGI:105082
    See related
    Ensembl:ENSMUSG00000021427 AllianceGenome:MGI:105082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SSR; TRAPA; 6330400D04; 2510001K09Rik
    Summary
    Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; bone; genitourinary system; respiratory system; and tail mesenchyme. Orthologous to human SSR1 (signal sequence receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 16.8), CNS E11.5 (RPKM 10.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A3.3; 13 17.86 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (38155377..38178184, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (37971401..37994208, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37870871-37870980 Neighboring gene predicted gene, 31600 Neighboring gene STARR-positive B cell enhancer mm9_chr13:37884809-37885110 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37893604-37893840 Neighboring gene ras responsive element binding protein 1 Neighboring gene predicted gene, 46411 Neighboring gene STARR-positive B cell enhancer ABC_E1461 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37972487-37972670 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37974410-37974611 Neighboring gene STARR-seq mESC enhancer starr_34234 Neighboring gene STARR-positive B cell enhancer ABC_E11541 Neighboring gene STARR-positive B cell enhancer ABC_E7227 Neighboring gene STARR-positive B cell enhancer ABC_E10789 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:38086110-38086293 Neighboring gene predicted gene, 52041 Neighboring gene STARR-positive B cell enhancer ABC_E9396 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:38129215-38129324 Neighboring gene cancer antigen 1 Neighboring gene RIO kinase 1 Neighboring gene STARR-seq mESC enhancer starr_34240 Neighboring gene STARR-seq mESC enhancer starr_34241 Neighboring gene desmoplakin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Unexpected behavior of a gene trap vector comprising a fusion between the Sh ble and the lacZ genes. Camus A, et al. Mol Reprod Dev, 1996 Nov. PMID 8916035
    2. Mutation in the Trapalpha/Ssr1 gene, encoding translocon-associated protein alpha, results in outflow tract morphogenetic defects. Mesbah K, et al. Mol Cell Biol, 2006 Oct. PMID 17015483, Free PMC Article
    3. Developmental regulation of membrane traffic organization during synaptogenesis in mouse diaphragm muscle. Antony C, et al. J Cell Biol, 1995 Aug. PMID 7642711, Free PMC Article
    4. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin. Zhang B, et al. Blood, 2011 Sep 22. PMID 21795745, Free PMC Article
    5. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. Bard-Chapeau EA, et al. PLoS One, 2014. PMID 24586749, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRAPalpha could be involved in translocation of factors necessary for maturation of endocardial cushions
      Title: Mutation in the Trapalpha/Ssr1 gene, encoding translocon-associated protein alpha, results in outflow tract morphogenetic defects.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1)  1 citation
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    translocon-associated protein subunit alpha
    Names
    SSR-alpha
    TRAP-alpha
    signal sequence receptor subunit alpha
    translocon-associated protein alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360842.1 → NP_001347771.1  translocon-associated protein subunit alpha isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CT010477
      UniProtKB/TrEMBL
      A0A286YCT4
      Related
      ENSMUSP00000153120.2, ENSMUST00000225246.2
      Conserved Domains (1) summary
      pfam03896
      Location:21 → 285
      TRAP_alpha; Translocon-associated protein (TRAP), alpha subunit

    2. NM_025965.4 → NP_080241.3  translocon-associated protein subunit alpha isoform 1 precursor

      See identical proteins and their annotated locations for NP_080241.3

      Status: VALIDATED

      Source sequence(s)
      AK010884, BB619494, CT010477
      Consensus CDS
      CCDS26459.1
      UniProtKB/Swiss-Prot
      Q3TIM3, Q99MP2, Q9CY50
      UniProtKB/TrEMBL
      Q3TV94
      Related
      ENSMUSP00000021864.7, ENSMUST00000021864.8
      Conserved Domains (1) summary
      pfam03896
      Location:18 → 280
      TRAP_alpha; Translocon-associated protein (TRAP), alpha subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      38155377..38178184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CY50.1 GenPept UniProtKB/Swiss-Prot:Q9CY50

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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