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    Eci3 enoyl-Coenzyme A delta isomerase 3 [ Mus musculus (house mouse) ]

    Gene ID: 69123, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Eci3provided by MGI
    Official Full Name
    enoyl-Coenzyme A delta isomerase 3provided by MGI
    Primary source
    MGI:MGI:1916373
    See related
    Ensembl:ENSMUSG00000021416 AllianceGenome:MGI:1916373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kseg2; 1810022C23Rik
    Summary
    Enables dodecenoyl-CoA delta-isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Located in peroxisome. Orthologous to human ECI2 (enoyl-CoA delta isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 36.9), large intestine adult (RPKM 4.5) and 2 other tissues See more
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    Genomic context

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    See Eci3 in Genome Data Viewer
    Location:
    13 A3.3; 13 14.23 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (35130595..35147971, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (34946614..34963988, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34164 Neighboring gene family with sequence similarity 217, member A Neighboring gene testis expressed 56 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_34165 Neighboring gene predicted gene, 16984 Neighboring gene STARR-seq mESC enhancer starr_34167 Neighboring gene enoyl-Coenzyme A delta isomerase 2 Neighboring gene STARR-seq mESC enhancer starr_34168 Neighboring gene predicted gene, 46408 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:35127596-35127929 Neighboring gene STARR-seq mESC enhancer starr_34169 Neighboring gene predicted gene, 40910

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of Eci3, a murine kidney-specific Δ3,Δ2-enoyl-CoA isomerase. van Weeghel M, et al. FASEB J, 2014 Mar. PMID 24344334
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mouse Eci3 is almost exclusively expressed in kidney.
      Title: Identification and characterization of Eci3, a murine kidney-specific Δ3,Δ2-enoyl-CoA isomerase.
    2. Eci3 specifically evolved in rodents after gene duplication of Eci2 and is localized to the peroxisomes
      Title: Identification and characterization of Eci3, a murine kidney-specific Δ3,Δ2-enoyl-CoA isomerase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables intramolecular oxidoreductase activity, transposing C=C bonds ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid beta-oxidation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    enoyl-CoA delta isomerase 3, peroxisomal
    Names
    D3,D2-enoyl-CoA isomerase
    delta(3),delta(2)-enoyl-CoA isomerase
    dodecenoyl-CoA isomerase
    kidney specific expressed protein 2
    NP_001405475.1
    NP_001405476.1
    NP_081223.1
    XP_011242645.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418546.1 → NP_001405475.1  enoyl-CoA delta isomerase 3, peroxisomal isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124537
      UniProtKB/Swiss-Prot
      D3U0D8, Q78JN3
      Related
      ENSMUSP00000132701.2, ENSMUST00000164155.2

    2. NM_001418547.1 → NP_001405476.1  enoyl-CoA delta isomerase 3, peroxisomal isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124537

    3. NM_026947.5 → NP_081223.1  enoyl-CoA delta isomerase 3, peroxisomal isoform 1

      See identical proteins and their annotated locations for NP_081223.1

      Status: VALIDATED

      Source sequence(s)
      AC124537
      Consensus CDS
      CCDS26449.1
      UniProtKB/Swiss-Prot
      D3U0D8, Q78JN3
      UniProtKB/TrEMBL
      E9PY42
      Related
      ENSMUSP00000021853.6, ENSMUST00000021853.12
      Conserved Domains (2) summary
      cd06558
      Location:64 → 256
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
      pfam00887
      Location:2 → 37
      ACBP; Acyl CoA binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      35130595..35147971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244343.3 → XP_011242645.1  enoyl-CoA delta isomerase 3, peroxisomal isoform X2

      UniProtKB/TrEMBL
      E9PY42
      Conserved Domains (2) summary
      cd06558
      Location:64 → 220
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
      pfam00887
      Location:2 → 37
      ACBP; Acyl CoA binding protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q78JN3.1 GenPept UniProtKB/Swiss-Prot:Q78JN3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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