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    Gpr132 G protein-coupled receptor 132 [ Mus musculus (house mouse) ]

    Gene ID: 56696, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gpr132provided by MGI
    Official Full Name
    G protein-coupled receptor 132provided by MGI
    Primary source
    MGI:MGI:1890220
    See related
    Ensembl:ENSMUSG00000021298 AllianceGenome:MGI:1890220
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G2a
    Summary
    Predicted to enable G protein-coupled receptor activity. Involved in negative regulation of G2/M transition of mitotic cell cycle. Acts upstream of or within G1/S transition of mitotic cell cycle. Predicted to be integral component of plasma membrane. Is expressed in thymus primordium. Used to study autoimmune disease. Orthologous to human GPR132 (G protein-coupled receptor 132). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 78.1), spleen adult (RPKM 34.3) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr132 in Genome Data Viewer
    Location:
    12 F1; 12 61.25 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112814493..112832035, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112850873..112868416, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene clathrin binding box of aftiphilin containing 1 Neighboring gene STARR-seq mESC enhancer starr_33365 Neighboring gene STARR-seq mESC enhancer starr_33367 Neighboring gene cell division cycle associated 4 Neighboring gene predicted gene, 52009 Neighboring gene STARR-seq mESC enhancer starr_33369 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114093201-114093409 Neighboring gene predicted gene, 30461 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114108177-114108360 Neighboring gene RIKEN cDNA 1700127F24 gene Neighboring gene jagged 2 Neighboring gene microRNA 6941

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of the mammalian G-protein coupled receptor, G2A, modulates severity of invasive pulmonary aspergillosis. Steffan BN, et al. Front Immunol, 2023. PMID 37435068, Free PMC Article
    2. Oxidized linoleic acid metabolites maintain mechanical and thermal hypersensitivity during sub-chronic inflammatory pain. Wedel S, et al. Biochem Pharmacol, 2022 Apr. PMID 35149052
    3. The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain. Osthues T, et al. Cells, 2020 Jul 21. PMID 32708184, Free PMC Article
    4. The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue. Kern K, et al. Front Immunol, 2018. PMID 30327654, Free PMC Article
    5. G2A as a Threshold Regulator of Inflammatory Hyperalgesia Modulates Chronic Hyperalgesia. Su YS, et al. J Mol Neurosci, 2018 Jan. PMID 29159784

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of the mammalian G-protein coupled receptor, G2A, modulates severity of invasive pulmonary aspergillosis.
      Title: Loss of the mammalian G-protein coupled receptor, G2A, modulates severity of invasive pulmonary aspergillosis.
    2. Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia.
      Title: Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia.
    3. The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages.
      Title: The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages.
    4. Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in Inflammatory Response by Promoting Classical Macrophage Activation.
      Title: Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in Inflammatory Response by Promoting Classical Macrophage Activation.
    5. The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain.
      Title: The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain.
    6. this study shows that G2A protects mice againstsSepsis by modulating Kupffer cell activation via cooperativity with adenosine receptor 2b
      Title: G2A Protects Mice against Sepsis by Modulating Kupffer Cell Activation: Cooperativity with Adenosine Receptor 2b.
    7. G2A is necessary to position macrophages in the proinflammatory microenvironment surrounding the center of inflammation. In absence of G2A the macrophages are localized in an antiinflammatory microenvironment and macrophage polarization is shifted toward M2-like macrophages.
      Title: The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue.
    8. GPR132 responds to a select panel of oxygenated polyunsaturated fatty acids to enhance both embryonic and adult hematopoiesis.
      Title: Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132.
    9. G2A overexpression reduced the infiltration of granulocytes and attenuated hyperalgesia after CFA injection. G2A knockdown increased the number of immune cells before CFA injection and prolonged the inflammatory hyperalgesia.
      Title: G2A as a Threshold Regulator of Inflammatory Hyperalgesia Modulates Chronic Hyperalgesia.
    10. Lactate activates macrophage Gpr132 to promote the alternatively activated macrophage (M2)-like phenotype, which, in turn, facilitates cancer cell adhesion, migration, and invasion. Consequently, Gpr132 deletion reduces M2 macrophages and impedes breast cancer lung metastasis in mice.
      Title: Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 132
    Names
    G protein-coupled receptor G2A
    G2 accumulation protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019925.4 → NP_064309.1  probable G-protein coupled receptor 132

      See identical proteins and their annotated locations for NP_064309.1

      Status: PROVISIONAL

      Source sequence(s)
      AK153765
      Consensus CDS
      CCDS26199.1
      UniProtKB/Swiss-Prot
      Q0VBS4, Q3U5A4, Q9Z282
      Related
      ENSMUSP00000021729.8, ENSMUST00000021729.9
      Conserved Domains (2) summary
      cd14964
      Location:46 → 66
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:46 → 317
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      112814493..112832035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516102.4 → XP_006516165.1  probable G-protein coupled receptor 132 isoform X1

      See identical proteins and their annotated locations for XP_006516165.1

      UniProtKB/Swiss-Prot
      Q0VBS4, Q3U5A4, Q9Z282
      Conserved Domains (2) summary
      cd14964
      Location:46 → 66
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:46 → 317
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006516103.2 → XP_006516166.1  probable G-protein coupled receptor 132 isoform X1

      See identical proteins and their annotated locations for XP_006516166.1

      UniProtKB/Swiss-Prot
      Q0VBS4, Q3U5A4, Q9Z282
      Conserved Domains (2) summary
      cd14964
      Location:46 → 66
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:46 → 317
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z282.1 GenPept UniProtKB/Swiss-Prot:Q9Z282

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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