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    Erg28 ergosterol biosynthesis 28 [ Mus musculus (house mouse) ]

    Gene ID: 58520, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Erg28provided by MGI
    Official Full Name
    ergosterol biosynthesis 28provided by MGI
    Primary source
    MGI:MGI:1915571
    See related
    Ensembl:ENSMUSG00000021252 AllianceGenome:MGI:1915571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORF11; 0610007P14Rik; 1190004E09Rik
    Summary
    Predicted to enable identical protein binding activity and protein-macromolecule adaptor activity. Predicted to act upstream of or within sterol biosynthetic process. Predicted to be located in transport vesicle. Predicted to be active in endoplasmic reticulum. Is expressed in brain and telencephalon. Orthologous to human ERG28 (ergosterol biosynthesis 28 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 36.5), placenta adult (RPKM 33.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Erg28 in Genome Data Viewer
    Location:
    12 D2; 12 39.81 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85862221..85871667, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85815447..85824893, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded rRNA 5S 64 Neighboring gene STARR-seq mESC enhancer starr_32787 Neighboring gene feline leukemia virus subgroup C cellular receptor 2 Neighboring gene predicted gene, 40478 Neighboring gene STARR-seq mESC enhancer starr_32788 Neighboring gene STARR-seq mESC enhancer starr_32789 Neighboring gene tubulin tyrosine ligase-like family, member 5 Neighboring gene predicted gene, 51990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:87310644-87310901 Neighboring gene STARR-positive B cell enhancer ABC_E5341 Neighboring gene predicted gene, 51989

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The genomic structure of c14orf1 is conserved across eukarya. Ottolenghi C, et al. Mamm Genome, 2000 Sep. PMID 10967139
    2. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Easterday MC, et al. Dev Biol, 2003 Dec 15. PMID 14651920
    3. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 0610007P14Rik, 1190004E09Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ergosterol biosynthetic protein 28 homolog
    Names
    c14orf1-like protein
    probable ergosterol biosynthetic protein 28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360451.1 → NP_001347380.1  ergosterol biosynthetic protein 28 homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice acceptor site in the 5' UTR region, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC138303, AI844820, DV047491
      Consensus CDS
      CCDS26063.1
      UniProtKB/Swiss-Prot
      Q3U8G1, Q9ERY9
      Conserved Domains (1) summary
      pfam03694
      Location:8 → 115
      Erg28; Erg28 like protein

    2. NM_001360813.1 → NP_001347742.1  ergosterol biosynthetic protein 28 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC138303, AI851047, BE656456
      Conserved Domains (1) summary
      pfam03694
      Location:8 → 75
      Erg28; Erg28 like protein

    3. NM_021446.3 → NP_067421.1  ergosterol biosynthetic protein 28 homolog isoform 1

      See identical proteins and their annotated locations for NP_067421.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC138303, AI844820, AK004480
      Consensus CDS
      CCDS26063.1
      UniProtKB/Swiss-Prot
      Q3U8G1, Q9ERY9
      Related
      ENSMUSP00000021676.6, ENSMUST00000021676.12
      Conserved Domains (1) summary
      pfam03694
      Location:8 → 115
      Erg28; Erg28 like protein

    RNA

    1. NR_153807.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice donor site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC138303, AI844820, AK004480

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      85862221..85871667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003950072.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERY9.1 GenPept UniProtKB/Swiss-Prot:Q9ERY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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