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    Papln papilin, proteoglycan-like sulfated glycoprotein [ Mus musculus (house mouse) ]

    Gene ID: 170721, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Paplnprovided by MGI
    Official Full Name
    papilin, proteoglycan-like sulfated glycoproteinprovided by MGI
    Primary source
    MGI:MGI:2386139
    See related
    Ensembl:ENSMUSG00000021223 AllianceGenome:MGI:2386139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E030033C16Rik
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to act upstream of or within negative regulation of peptidase activity. Located in basement membrane. Is expressed in alimentary system; male reproductive gland or organ; skin; and vagina. Orthologous to human PAPLN (papilin, proteoglycan like sulfated glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 17.7), ovary adult (RPKM 6.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 D1; 12 38.87 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (83809769..83841914)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (83762994..83795140)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7159 Neighboring gene presenilin 1 Neighboring gene STARR-positive B cell enhancer ABC_E3061 Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene NUMB endocytic adaptor protein Neighboring gene STARR-seq mESC enhancer starr_32718 Neighboring gene predicted gene, 46367 Neighboring gene endothelin converting enzyme 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases. Kramerova IA, et al. Development, 2000 Dec. PMID 11076767
    2. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
    3. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
    4. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Naba A, et al. Mol Cell Proteomics, 2012 Apr. PMID 22159717, Free PMC Article
    5. Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Desai J, et al. Hum Mol Genet, 2006 Apr 15. PMID 16537572

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    papilin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205343.1 → NP_001192272.1  papilin isoform 1 precursor

      See identical proteins and their annotated locations for NP_001192272.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132954, AK053198, BC144975
      Consensus CDS
      CCDS56847.1
      UniProtKB/TrEMBL
      B7ZN28
      Related
      ENSMUSP00000113806.2, ENSMUST00000121733.8
      Conserved Domains (7) summary
      smart00209
      Location:30 → 81
      TSP1; Thrombospondin type 1 repeats
      pfam00014
      Location:771 → 822
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam05986
      Location:184 → 299
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam07679
      Location:1070 → 1141
      I-set; Immunoglobulin I-set domain
      pfam08686
      Location:1257 → 1289
      PLAC; PLAC (protease and lacunin) domain
      pfam16626
      Location:831 → 922
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cl11960
      Location:1157 → 1241
      Ig; Immunoglobulin domain

    2. NM_130887.3 → NP_570957.2  papilin isoform 2 precursor

      See identical proteins and their annotated locations for NP_570957.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC132954, BC132475
      Consensus CDS
      CCDS26031.1
      UniProtKB/Swiss-Prot
      A2RTE8, B2RQC4, Q99JQ8, Q9EPX2
      Related
      ENSMUSP00000021646.6, ENSMUST00000021646.6
      Conserved Domains (9) summary
      smart00209
      Location:30 → 81
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:184 → 299
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:809 → 900
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      pfam00014
      Location:749 → 801
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam07679
      Location:1048 → 1119
      I-set; Immunoglobulin I-set domain
      pfam08686
      Location:1235 → 1267
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:367 → 425
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cd00096
      Location:1059 → 1066
      Ig; Ig strand B [structural motif]
      cl11960
      Location:1135 → 1219
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      83809769..83841914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515505.5 → XP_006515568.1  papilin isoform X1

      See identical proteins and their annotated locations for XP_006515568.1

      UniProtKB/TrEMBL
      B7ZN28
      Conserved Domains (7) summary
      smart00209
      Location:30 → 81
      TSP1; Thrombospondin type 1 repeats
      pfam00014
      Location:771 → 822
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam05986
      Location:184 → 299
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam07679
      Location:1070 → 1141
      I-set; Immunoglobulin I-set domain
      pfam08686
      Location:1257 → 1289
      PLAC; PLAC (protease and lacunin) domain
      pfam16626
      Location:831 → 922
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cl11960
      Location:1157 → 1241
      Ig; Immunoglobulin domain

    2. XM_011244005.4 → XP_011242307.1  papilin isoform X1

      See identical proteins and their annotated locations for XP_011242307.1

      UniProtKB/TrEMBL
      B7ZN28
      Conserved Domains (7) summary
      smart00209
      Location:30 → 81
      TSP1; Thrombospondin type 1 repeats
      pfam00014
      Location:771 → 822
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam05986
      Location:184 → 299
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam07679
      Location:1070 → 1141
      I-set; Immunoglobulin I-set domain
      pfam08686
      Location:1257 → 1289
      PLAC; PLAC (protease and lacunin) domain
      pfam16626
      Location:831 → 922
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      cl11960
      Location:1157 → 1241
      Ig; Immunoglobulin domain

    3. XM_036157202.1 → XP_036013095.1  papilin isoform X2

      UniProtKB/Swiss-Prot
      A2RTE8, B2RQC4, Q99JQ8, Q9EPX2
      Conserved Domains (9) summary
      smart00209
      Location:30 → 81
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:184 → 299
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam16626
      Location:809 → 900
      Papilin_u7; Linking region between Kunitz_BPTI and I-set on papilin
      pfam00014
      Location:749 → 801
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam07679
      Location:1048 → 1119
      I-set; Immunoglobulin I-set domain
      pfam08686
      Location:1235 → 1267
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:367 → 425
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cd00096
      Location:1059 → 1066
      Ig; Ig strand B [structural motif]
      cl11960
      Location:1135 → 1219
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPX2.2 GenPept UniProtKB/Swiss-Prot:Q9EPX2

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