Serpina1f serine (or cysteine) peptidase inhibitor, clade A, member 1F [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpina1fprovided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade A, member 1Fprovided by MGI
Primary source: MGI:MGI:1915598
See related: Ensembl:ENSMUSG00000021081 AllianceGenome:MGI:1915598
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: epserin; Serpina2; 0610012A11Rik
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular space. Orthologous to human SERPINA2 (serpin family A member 2 (gene/pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 310.1) See more
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Genomic context

Location:: 12 E; 12 52.98 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (103654303..103661788, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (103688044..103695529, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487577

AI327419 (e-PCR)
- UniSTS:165842

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha-1-antitrypsin 1-6

Names: alpha-1 protease inhibitor 6; alpha-1-antiproteinase; epididymal serine protease inhibitor; epsin; serine protease inhibitor 1-6; serine protease inhibitor A1f; serpin A1f

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164742.1 → NP_001158214.1 alpha-1-antitrypsin 1-6 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AK002574, AK165409

Consensus CDS

CCDS49155.1

UniProtKB/TrEMBL

E9PUC6, Q08EA5

Related

ENSMUSP00000112533.2, ENSMUST00000117053.8

Conserved Domains (1) summary

cl00137
Location:55 → 351

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
NM_026687.2 → NP_080963.2 alpha-1-antitrypsin 1-6 isoform 1 precursor

See identical proteins and their annotated locations for NP_080963.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC098741, AK002574, AK165409

Consensus CDS

CCDS26137.1

UniProtKB/TrEMBL

G3X9Z5, Q08EA5

Related

ENSMUSP00000021490.6, ENSMUST00000021490.12

Conserved Domains (1) summary

pfam00079
Location:48 → 409

Serpin; Serpin (serine protease inhibitor)