U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ankfy1 ankyrin repeat and FYVE domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 11736, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ankfy1provided by MGI
    Official Full Name
    ankyrin repeat and FYVE domain containing 1provided by MGI
    Primary source
    MGI:MGI:1337008
    See related
    Ensembl:ENSMUSG00000020790 AllianceGenome:MGI:1337008
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ankhzn; ZFYVE14; mKIAA1255
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity and small GTPase binding activity. Predicted to be involved in cytosolic transport; endosomal vesicle fusion; and positive regulation of pinocytosis. Located in endosome membrane. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; eye; and genitourinary system. Used to study Charlevoix-Saguenay spastic ataxia. Orthologous to human ANKFY1 (ankyrin repeat and FYVE domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 14.1), large intestine adult (RPKM 13.9) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    11 B4; 11 44.47 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72580828..72662972)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72690002..72772146)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29914 Neighboring gene predicted gene, 51906 Neighboring gene predicted gene 12712 Neighboring gene STARR-positive B cell enhancer ABC_E2360 Neighboring gene STARR-positive B cell enhancer ABC_E5245 Neighboring gene ubiquitin-conjugating enzyme E2G 1 Neighboring gene predicted gene, 24143 Neighboring gene STARR-seq mESC enhancer starr_29916 Neighboring gene STARR-positive B cell enhancer ABC_E7012 Neighboring gene predicted gene, 46287 Neighboring gene STARR-positive B cell enhancer ABC_E8424 Neighboring gene cytochrome b5 domain containing 2 Neighboring gene zinc finger, ZZ-type with EF hand domain 1 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ankfy1 Is Involved in the Maintenance of Cerebellar Purkinje Cells. Chang L, et al. Front Cell Neurosci, 2021. PMID 33796010, Free PMC Article
    2. [Possible involvement of Ankhzn, a novel protein possessing FYVE domain, in cellular endocytosis and autophagocytosis in vitro]. Ishii N, et al. Kaibogaku Zasshi, 2003 Jun. PMID 12833855
    3. Characterization and chromosomal mapping of a novel human gene, ANKHZN. Kuriyama H, et al. Gene, 2000 Aug 8. PMID 10940552
    4. Molecular cloning of a novel 130-kDa cytoplasmic protein, Ankhzn, containing Ankyrin repeats hooked to a zinc finger motif. Ito K, et al. Biochem Biophys Res Commun, 1999 Apr 2. PMID 10092534
    5. Ankfy1 is dispensable for neural stem/precursor cell development. Weng C, et al. Neural Regen Res, 2016 Nov. PMID 28123425, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. is essential for the formation of endocytotic and autophagocytotic vesicles.
      Title: [Possible involvement of Ankhzn, a novel protein possessing FYVE domain, in cellular endocytosis and autophagocytosis in vitro].
    2. Rab5 regulates and coordinates different endocytic mechanisms through its effector Rabankyrin-5
      Title: The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of pinocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in macropinosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    rabankyrin-5
    Names
    Rabankyrin-5
    ankyrin repeat and FYVE domain-containing protein 1
    ankyrin repeat hooked to a zinc finger motif
    ankyrin repeat hooked to zinc finger motif
    ankyrin repeats hooked to a zinc finger motif
    rank-5

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009671.5 → NP_033801.4  rabankyrin-5

      See identical proteins and their annotated locations for NP_033801.4

      Status: VALIDATED

      Source sequence(s)
      AL663082, AL808023
      Consensus CDS
      CCDS24989.1
      UniProtKB/Swiss-Prot
      B1ATS3, O54807, Q80TG6, Q80UH8, Q810B6
      UniProtKB/TrEMBL
      B7ZP20
      Related
      ENSMUSP00000118751.2, ENSMUST00000155998.2
      Conserved Domains (8) summary
      smart00225
      Location:69 → 156
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:167 → 235
      BACK; BTB And C-terminal Kelch
      cd00204
      Location:866 → 992
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd15728
      Location:1101 → 1163
      FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
      pfam00651
      Location:61 → 156
      BTB; BTB/POZ domain
      pfam12796
      Location:875 → 969
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:353 → 408
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:726 → 767
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      72580828..72662972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245484.2 → XP_030101344.1  rabankyrin-5 isoform X2

      Conserved Domains (4) summary
      PHA02876
      Location:22 → 384
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:247 → 538
      PHA03095; ankyrin-like protein; Provisional
      cd15728
      Location:646 → 708
      FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
      sd00045
      Location:271 → 312
      ANK; ANK repeat [structural motif]

    2. XM_036156245.1 → XP_036012138.1  rabankyrin-5 isoform X1

      UniProtKB/TrEMBL
      B7ZP20
      Conserved Domains (7) summary
      PHA03095
      Location:544 → 835
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:391 → 590
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd15728
      Location:943 → 1005
      FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
      sd00045
      Location:568 → 609
      ANK; ANK repeat [structural motif]
      cd18501
      Location:4 → 92
      BACK_ANKFY1_Rank5; BACK (BTB and C-terminal Kelch) domain found in rabankyrin-5 (Rank-5)
      pfam13637
      Location:101 → 151
      Ank_4; Ankyrin repeats (many copies)
      cl39094
      Location:149 → 411
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810B6.2 GenPept UniProtKB/Swiss-Prot:Q810B6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous