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    Mboat2 membrane bound O-acyltransferase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 67216, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Mboat2provided by MGI
    Official Full Name
    membrane bound O-acyltransferase domain containing 2provided by MGI
    Primary source
    MGI:MGI:1914466
    See related
    Ensembl:ENSMUSG00000020646 AllianceGenome:MGI:1914466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oact2; LPCAT4; Moact2; 2810049G06Rik
    Summary
    Enables 1-acylglycerophosphocholine O-acyltransferase activity and 1-acylglycerophosphoethanolamine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and regulation of chondrocyte differentiation. Located in endoplasmic reticulum membrane. Is expressed in several structures, including T1 rib costal cartilage; alimentary system; genitourinary system; nervous system; and respiratory system. Orthologous to human MBOAT2 (membrane bound O-acyltransferase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 6.5), frontal lobe adult (RPKM 5.2) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 A1.3; 12 8.5 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (24881401..25014399)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (24831435..24964400)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900060N12 gene Neighboring gene STARR-seq mESC enhancer starr_31760 Neighboring gene predicted gene, 26211 Neighboring gene STARR-positive B cell enhancer ABC_E5324 Neighboring gene kinase D-interacting substrate 220 Neighboring gene predicted gene, 36236 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:25695412-25695595 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:25777982-25778091 Neighboring gene STARR-positive B cell enhancer mm9_chr12:25780927-25781228 Neighboring gene inhibitor of DNA binding 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lysophosphatidylcholine acyltransferase 4 is involved in chondrogenic differentiation of ATDC5 cells. Tabe S, et al. Sci Rep, 2017 Dec 1. PMID 29196633, Free PMC Article
    2. Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Hishikawa D, et al. Proc Natl Acad Sci U S A, 2008 Feb 26. PMID 18287005, Free PMC Article
    3. LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. Tamaki H, et al. J Biol Chem, 2007 Nov 23. PMID 17890783
    4. A complex oscillating network of signaling genes underlies the mouse segmentation clock. Dequéant ML, et al. Science, 2006 Dec 8. PMID 17095659
    5. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-acylglycerophosphocholine O-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 1-acylglycerophosphocholine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-acylglycerophosphoethanolamine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-acylglycerophosphoserine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylcholine acyl-chain remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylcholine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylethanolamine acyl-chain remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylethanolamine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylserine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysophospholipid acyltransferase 2
    Names
    1-acylglycerophosphocholine O-acyltransferase
    1-acylglycerophosphoethanolamine O-acyltransferase
    LPC acyltransferase 4
    LPCAT
    LPEAT
    LPLAT 2
    O-acyltransferase (membrane bound) domain containing 2
    O-acyltransferase domain-containing protein 2
    lyso-PC acyltransferase 4
    lyso-PE acyltransferase
    lysophosphatidylcholine acyltransferase 4
    lysophosphatidylethanolamine acyltransferase
    mLPCAT4
    membrane-bound O-acyltransferase domain-containing protein 2
    NP_001076810.1
    NP_080313.2
    XP_006515230.1
    XP_006515231.1
    XP_006515233.1
    XP_006515235.1
    XP_011242191.1
    XP_011242192.1
    XP_017170653.1
    XP_030102743.1
    XP_030102744.1
    XP_030102745.1
    XP_030102746.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083341.1 → NP_001076810.1  lysophospholipid acyltransferase 2 isoform b

      See identical proteins and their annotated locations for NP_001076810.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a.
      Source sequence(s)
      AC159307, AK003295, AK031824, AU067514
      Consensus CDS
      CCDS36423.1
      UniProtKB/Swiss-Prot
      Q8R3I2
      UniProtKB/TrEMBL
      Q8BN01
      Related
      ENSMUSP00000152348.2, ENSMUST00000221952.2
      Conserved Domains (1) summary
      cl00738
      Location:13 → 444
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    2. NM_026037.3 → NP_080313.2  lysophospholipid acyltransferase 2 isoform a

      See identical proteins and their annotated locations for NP_080313.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a).
      Source sequence(s)
      AC159307, AK003295, AK031824, AK034873, AU067514
      Consensus CDS
      CCDS25845.1
      UniProtKB/Swiss-Prot
      A9EDS7, Q8BHH5, Q8BM56, Q8R192, Q8R3I2, Q9CZ73
      Related
      ENSMUSP00000106567.4, ENSMUST00000110942.11
      Conserved Domains (1) summary
      cl00738
      Location:13 → 476
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      24881401..25014399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515172.5 → XP_006515235.1  lysophospholipid acyltransferase 2 isoform X4

      See identical proteins and their annotated locations for XP_006515235.1

      UniProtKB/TrEMBL
      A0A217FL69
      Conserved Domains (1) summary
      cl00738
      Location:2 → 325
      MBOAT; membrane-bound O-acyltransferase family

    2. XM_030246884.2 → XP_030102744.1  lysophospholipid acyltransferase 2 isoform X3

      UniProtKB/TrEMBL
      A0A217FL69
      Conserved Domains (1) summary
      cl00738
      Location:8 → 335
      MBOAT; membrane-bound O-acyltransferase family

    3. XM_006515167.5 → XP_006515230.1  lysophospholipid acyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006515230.1

      UniProtKB/TrEMBL
      A0A217FL69
      Conserved Domains (1) summary
      cl00738
      Location:1 → 387
      MBOAT; membrane-bound O-acyltransferase family

    4. XM_006515168.2 → XP_006515231.1  lysophospholipid acyltransferase 2 isoform X2

      UniProtKB/TrEMBL
      A0A217FL69
      Related
      ENSMUSP00000077937.8, ENSMUST00000078902.8
      Conserved Domains (1) summary
      cl00738
      Location:13 → 355
      MBOAT; membrane-bound O-acyltransferase family

    5. XM_011243889.3 → XP_011242191.1  lysophospholipid acyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_011242191.1

      UniProtKB/TrEMBL
      A0A217FL69
      Conserved Domains (1) summary
      cl00738
      Location:1 → 387
      MBOAT; membrane-bound O-acyltransferase family

    6. XM_030246883.2 → XP_030102743.1  lysophospholipid acyltransferase 2 isoform X2

      UniProtKB/TrEMBL
      A0A217FL69
      Conserved Domains (1) summary
      cl00738
      Location:13 → 355
      MBOAT; membrane-bound O-acyltransferase family

    7. XM_030246886.2 → XP_030102746.1  lysophospholipid acyltransferase 2 isoform X4

      UniProtKB/TrEMBL
      A0A217FL69
      Conserved Domains (1) summary
      cl00738
      Location:2 → 325
      MBOAT; membrane-bound O-acyltransferase family

    8. XM_006515170.5 → XP_006515233.1  lysophospholipid acyltransferase 2 isoform X3

      See identical proteins and their annotated locations for XP_006515233.1

      UniProtKB/TrEMBL
      A0A217FL69
      Conserved Domains (1) summary
      cl00738
      Location:8 → 335
      MBOAT; membrane-bound O-acyltransferase family

    9. XM_017315164.3 → XP_017170653.1  lysophospholipid acyltransferase 2 isoform X4

      UniProtKB/TrEMBL
      A0A217FL69
      Conserved Domains (1) summary
      cl00738
      Location:2 → 325
      MBOAT; membrane-bound O-acyltransferase family

    10. XM_030246885.2 → XP_030102745.1  lysophospholipid acyltransferase 2 isoform X4

      UniProtKB/TrEMBL
      A0A217FL69
      Conserved Domains (1) summary
      cl00738
      Location:2 → 325
      MBOAT; membrane-bound O-acyltransferase family

    11. XM_011243890.3 → XP_011242192.1  lysophospholipid acyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_011242192.1

      UniProtKB/TrEMBL
      A0A217FL69
      Conserved Domains (1) summary
      cl00738
      Location:1 → 387
      MBOAT; membrane-bound O-acyltransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3I2.1 GenPept UniProtKB/Swiss-Prot:Q8R3I2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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