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    Trappc12 trafficking protein particle complex 12 [ Mus musculus (house mouse) ]

    Gene ID: 217449, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Trappc12provided by MGI
    Official Full Name
    trafficking protein particle complex 12provided by MGI
    Primary source
    MGI:MGI:2445089
    See related
    Ensembl:ENSMUSG00000020628 AllianceGenome:MGI:2445089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ttc15; CGI-87; D930014A20Rik
    Summary
    Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of protein localization to kinetochore; and regulation of kinetochore assembly. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in kinetochore and nucleoplasm. Predicted to be part of TRAPP complex. Predicted to be active in Golgi apparatus. Predicted to colocalize with endoplasmic reticulum-Golgi intermediate compartment and perinuclear region of cytoplasm. Orthologous to human TRAPPC12 (trafficking protein particle complex subunit 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 7.2), bladder adult (RPKM 7.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 A2; 12 11.1 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (28740619..28801746, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (28690620..28750485, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ribonuclease H1 Neighboring gene microRNA 6937 Neighboring gene acireductone dioxygenase 1 Neighboring gene STARR-seq mESC enhancer starr_31820 Neighboring gene STARR-positive B cell enhancer ABC_E9386 Neighboring gene predicted gene, 31269 Neighboring gene EARP complex and GARP complex interacting protein 1 Neighboring gene predicted gene, 46345 Neighboring gene STARR-seq mESC enhancer starr_31822 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:29519262-29519445 Neighboring gene STARR-seq mESC enhancer starr_31825 Neighboring gene STARR-seq mESC enhancer starr_31826 Neighboring gene predicted gene, 31508

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRAPP Complexes in Secretion and Autophagy. Kim JJ, et al. Front Cell Dev Biol, 2016. PMID 27066478, Free PMC Article
    2. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in COPII vesicle coating NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of kinetochore assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle tethering NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TRAPPIII protein complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    colocalizes_with endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    trafficking protein particle complex subunit 12
    Names
    TPR repeat protein 15
    tetratricopeptide repeat domain 15
    tetratricopeptide repeat protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161410.2 → NP_001154882.1  trafficking protein particle complex subunit 12 isoform 1

      See identical proteins and their annotated locations for NP_001154882.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC136986
      Consensus CDS
      CCDS25854.1
      UniProtKB/Swiss-Prot
      E9QLQ6, Q8BX27, Q8K2L8
      UniProtKB/TrEMBL
      Q3UGE1
      Related
      ENSMUSP00000127752.3, ENSMUST00000168129.10
      Conserved Domains (5) summary
      TIGR02795
      Location:600 → 670
      tol_pal_ybgF; tol-pal system protein YbgF
      PHA03307
      Location:1 → 380
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00006
      Location:608 → 635
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:644 → 711
      TPR_12; Tetratricopeptide repeat
      pfam15782
      Location:214 → 332
      GREB1; Gene regulated by oestrogen in breast cancer

    2. NM_001161411.2 → NP_001154883.1  trafficking protein particle complex subunit 12 isoform 2

      See identical proteins and their annotated locations for NP_001154883.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC136986
      Consensus CDS
      CCDS49040.1
      UniProtKB/TrEMBL
      Q8BUB5, Q8C0C3
      Related
      ENSMUSP00000132009.2, ENSMUST00000170994.3
      Conserved Domains (1) summary
      pfam15782
      Location:214 → 332
      GREB1; Gene regulated by oestrogen in breast cancer

    3. NM_001377005.1 → NP_001363934.1  trafficking protein particle complex subunit 12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC136986
      UniProtKB/TrEMBL
      Q8BUB5, Q8C0C3
      Conserved Domains (1) summary
      pfam15782
      Location:214 → 332
      GREB1; Gene regulated by oestrogen in breast cancer

    4. NM_001377006.1 → NP_001363935.1  trafficking protein particle complex subunit 12 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC136986
      UniProtKB/TrEMBL
      Q3UGE1
      Conserved Domains (5) summary
      TIGR02795
      Location:600 → 671
      tol_pal_ybgF; tol-pal system protein YbgF
      PHA03307
      Location:1 → 380
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00006
      Location:608 → 635
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:644 → 712
      TPR_12; Tetratricopeptide repeat
      pfam15782
      Location:214 → 332
      GREB1; Gene regulated by oestrogen in breast cancer

    5. NM_001377007.1 → NP_001363936.1  trafficking protein particle complex subunit 12 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC136986
      UniProtKB/Swiss-Prot
      E9QLQ6, Q8BX27, Q8K2L8
      UniProtKB/TrEMBL
      Q3UGE1
      Conserved Domains (5) summary
      TIGR02795
      Location:600 → 670
      tol_pal_ybgF; tol-pal system protein YbgF
      PHA03307
      Location:1 → 380
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00006
      Location:608 → 635
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:644 → 711
      TPR_12; Tetratricopeptide repeat
      pfam15782
      Location:214 → 332
      GREB1; Gene regulated by oestrogen in breast cancer

    6. NM_178811.5 → NP_848926.3  trafficking protein particle complex subunit 12 isoform 1

      See identical proteins and their annotated locations for NP_848926.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC136986
      Consensus CDS
      CCDS25854.1
      UniProtKB/Swiss-Prot
      E9QLQ6, Q8BX27, Q8K2L8
      UniProtKB/TrEMBL
      Q3UGE1
      Related
      ENSMUSP00000020954.9, ENSMUST00000020954.15
      Conserved Domains (5) summary
      TIGR02795
      Location:600 → 670
      tol_pal_ybgF; tol-pal system protein YbgF
      PHA03307
      Location:1 → 380
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00006
      Location:608 → 635
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:644 → 711
      TPR_12; Tetratricopeptide repeat
      pfam15782
      Location:214 → 332
      GREB1; Gene regulated by oestrogen in breast cancer

    RNA

    1. NR_165042.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC136986

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      28740619..28801746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515059.3 → XP_006515122.1  trafficking protein particle complex subunit 12 isoform X1

      See identical proteins and their annotated locations for XP_006515122.1

      UniProtKB/TrEMBL
      Q3UGE1
      Conserved Domains (5) summary
      TIGR02795
      Location:600 → 671
      tol_pal_ybgF; tol-pal system protein YbgF
      PHA03307
      Location:1 → 380
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00006
      Location:608 → 635
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:644 → 712
      TPR_12; Tetratricopeptide repeat
      pfam15782
      Location:214 → 332
      GREB1; Gene regulated by oestrogen in breast cancer

    2. XM_006515057.3 → XP_006515120.1  trafficking protein particle complex subunit 12 isoform X1

      See identical proteins and their annotated locations for XP_006515120.1

      UniProtKB/TrEMBL
      Q3UGE1
      Conserved Domains (5) summary
      TIGR02795
      Location:600 → 671
      tol_pal_ybgF; tol-pal system protein YbgF
      PHA03307
      Location:1 → 380
      PHA03307; transcriptional regulator ICP4; Provisional
      sd00006
      Location:608 → 635
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:644 → 712
      TPR_12; Tetratricopeptide repeat
      pfam15782
      Location:214 → 332
      GREB1; Gene regulated by oestrogen in breast cancer

    3. XM_006515061.5 → XP_006515124.1  trafficking protein particle complex subunit 12 isoform X2

      UniProtKB/TrEMBL
      Q3TB00
      Conserved Domains (1) summary
      pfam15782
      Location:214 → 332
      GREB1; Gene regulated by oestrogen in breast cancer

    RNA

    1. XR_004937486.1 RNA Sequence

    2. XR_003950032.2 RNA Sequence

    3. XR_003950034.2 RNA Sequence

    4. XR_001780444.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2L8.2 GenPept UniProtKB/Swiss-Prot:Q8K2L8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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