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    Xpo1 exportin 1 [ Mus musculus (house mouse) ]

    Gene ID: 103573, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Xpo1provided by MGI
    Official Full Name
    exportin 1provided by MGI
    Primary source
    MGI:MGI:2144013
    See related
    Ensembl:ENSMUSG00000020290 AllianceGenome:MGI:2144013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crm1; Exp1
    Summary
    Enables nuclear export signal receptor activity. Acts upstream of or within several processes, including protein export from nucleus; regulation of centrosome duplication; and regulation of protein export from nucleus. Located in nucleus. Is expressed in several structures, including alimentary system; early embryo; nervous system; respiratory system; and sensory organ. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 31.7), limb E14.5 (RPKM 25.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A3.2; 11 14.28 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23205768..23248250)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23255909..23297597)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700061J23 gene Neighboring gene STARR-seq mESC enhancer starr_28906 Neighboring gene predicted gene, 24398 Neighboring gene STARR-seq mESC enhancer starr_28907 Neighboring gene STARR-seq mESC enhancer starr_28908 Neighboring gene STARR-positive B cell enhancer ABC_E729 Neighboring gene ubiquitin specific peptidase 34 Neighboring gene STARR-seq mESC enhancer starr_28911 Neighboring gene RIKEN cDNA 1700030C12 gene Neighboring gene STARR-positive B cell enhancer ABC_E9818 Neighboring gene predicted gene, 22753 Neighboring gene AHA1, activator of heat shock protein ATPase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML. Pianigiani G, et al. Blood Adv, 2022 Nov 22. PMID 36037515, Free PMC Article
    2. Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain. Gorostieta-Salas E, et al. Oxid Med Cell Longev, 2021. PMID 34434486, Free PMC Article
    3. Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells. Olazagoitia-Garmendia A, et al. Gut, 2022 Jan. PMID 33526437, Free PMC Article
    4. Structural basis for cooperativity of CRM1 export complex formation. Monecke T, et al. Proc Natl Acad Sci U S A, 2013 Jan 15. PMID 23277578, Free PMC Article
    5. Abundance of the largest subunit of RNA polymerase II in the nucleus is regulated by nucleo-cytoplasmic shuttling. Custódio N, et al. Exp Cell Res, 2006 Aug 1. PMID 16765347

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential impact of exportin-1-mediated nuclear export of RNAs on the RNA content of extracellular vesicle subpopulations.
      Title: Differential impact of exportin-1-mediated nuclear export of RNAs on the RNA content of extracellular vesicle subpopulations.
    2. Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML.
      Title: Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML.
    3. Hydrocortisone alleviates sepsis-induced acute kidney injury through HSF-1-mediated transcriptional suppression of XPO1.
      Title: Hydrocortisone alleviates sepsis-induced acute kidney injury through HSF-1-mediated transcriptional suppression of XPO1.
    4. Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain.
      Title: Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain.
    5. Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells.
      Title: Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells.
    6. Inhibition of Autism-Related Crm1 Disrupts Mitosis and Induces Apoptosis of the Cortical Neural Progenitors.
      Title: Inhibition of Autism-Related Crm1 Disrupts Mitosis and Induces Apoptosis of the Cortical Neural Progenitors.
    7. Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
      Title: Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
    8. NXF1 and CRM1 nuclear export pathways orchestrate nuclear export, translation and packaging of murine leukaemia retrovirus unspliced RNA.
      Title: NXF1 and CRM1 nuclear export pathways orchestrate nuclear export, translation and packaging of murine leukaemia retrovirus unspliced RNA.
    9. myeloid transformation requires the interaction of XPO1 with SETBP1
      Title: Interaction with XPO1 is essential for SETBP1 to induce myeloid transformation.
    10. Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias.
      Title: Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias: from concept to clinical trial.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear export signal receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear export signal receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nuclear export signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal subunit export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in annulate lamellae ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    exportin-1
    Names
    chromosome region maintenance 1 protein homolog
    exportin 1, CRM1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035226.1 → NP_001030303.1  exportin-1

      See identical proteins and their annotated locations for NP_001030303.1

      Status: VALIDATED

      Source sequence(s)
      AK037196, BC062912
      Consensus CDS
      CCDS24475.1
      UniProtKB/Swiss-Prot
      Q6P5F9
      Related
      ENSMUSP00000099934.2, ENSMUST00000102870.8
      Conserved Domains (1) summary
      COG5101
      Location:15 → 1044
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

    2. NM_001412406.1 → NP_001399335.1  exportin-1

      Status: VALIDATED

      Source sequence(s)
      AL772359
      UniProtKB/Swiss-Prot
      Q6P5F9

    3. NM_001412407.1 → NP_001399336.1  exportin-1

      Status: VALIDATED

      Source sequence(s)
      AL772359
      UniProtKB/Swiss-Prot
      Q6P5F9
      Related
      ENSMUSP00000099933.2, ENSMUST00000102869.8

    4. NM_001412408.1 → NP_001399337.1  exportin-1

      Status: VALIDATED

      Source sequence(s)
      AL772359
      UniProtKB/Swiss-Prot
      Q6P5F9

    5. NM_134014.3 → NP_598775.2  exportin-1

      See identical proteins and their annotated locations for NP_598775.2

      Status: VALIDATED

      Source sequence(s)
      AK037196, BC062912, CD347786
      Consensus CDS
      CCDS24475.1
      UniProtKB/Swiss-Prot
      Q6P5F9
      Conserved Domains (1) summary
      COG5101
      Location:15 → 1044
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      23205768..23248250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314209.3 → XP_017169698.1  exportin-1 isoform X3

      Conserved Domains (1) summary
      COG5101
      Location:1 → 913
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

    2. XM_017314208.3 → XP_017169697.1  exportin-1 isoform X2

      Conserved Domains (1) summary
      COG5101
      Location:10 → 978
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P5F9.1 GenPept UniProtKB/Swiss-Prot:Q6P5F9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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