Lyz3 lysozyme 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lyz3provided by MGI
Official Full Name: lysozyme 3provided by MGI
Primary source: MGI:MGI:1924647
See related: Ensembl:ENSMUSG00000020177 AllianceGenome:MGI:1924647
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lyzf1; 9530003J23Rik
Summary: Predicted to enable identical protein binding activity and lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and killing of cells of other organism. Predicted to be located in extracellular space. Is expressed in skeleton. Human ortholog(s) of this gene implicated in familial visceral amyloidosis. Orthologous to human LYZ (lysozyme). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 10 D2; 10 65.28 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (117069658..117074586, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (117233753..117238681, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lysozyme activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysozyme C-like

Names: lysozyme f1

NP_084182.2

EC 3.2.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029906.3 → NP_084182.2 lysozyme C-like precursor

See identical proteins and their annotated locations for NP_084182.2

Status: VALIDATED

Source sequence(s)

AC139638, AK035427, DV040577

Consensus CDS

CCDS24192.1

UniProtKB/TrEMBL

Q8BM26, Q9D249

Related

ENSMUSP00000020392.5, ENSMUST00000020392.5

Conserved Domains (1) summary

cd00119
Location:22 → 147

LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...