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    Pex12 peroxisomal biogenesis factor 12 [ Mus musculus (house mouse) ]

    Gene ID: 103737, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pex12provided by MGI
    Official Full Name
    peroxisomal biogenesis factor 12provided by MGI
    Primary source
    MGI:MGI:2144177
    See related
    Ensembl:ENSMUSG00000018733 AllianceGenome:MGI:2144177
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable protein C-terminus binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Predicted to be involved in protein import into peroxisome matrix and protein monoubiquitination. Predicted to act upstream of or within protein transport. Predicted to be located in peroxisomal membrane. Predicted to be part of peroxisomal importomer complex. Predicted to be integral component of peroxisomal membrane. Is expressed in esophagus; lung; mandible; and maxilla. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and peroxisome biogenesis disorder 3A. Orthologous to human PEX12 (peroxisomal biogenesis factor 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.3), adrenal adult (RPKM 5.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 C; 11 50.3 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83182757..83189849, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83295072..83299005, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23444 Neighboring gene schlafen 14 Neighboring gene STARR-positive B cell enhancer ABC_E1424 Neighboring gene STARR-positive B cell enhancer ABC_E8435 Neighboring gene expressed sequence AA465934 Neighboring gene expressed sequence AI450353 Neighboring gene STARR-seq mESC enhancer starr_30193 Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene adaptor-related protein complex 2, beta 1 subunit Neighboring gene STARR-seq mESC enhancer starr_30196 Neighboring gene predicted gene, 23951 Neighboring gene RAS-like, family 10, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence. Bustos O, et al. Gene, 2009 Nov 1. PMID 19619625, Free PMC Article
    2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin ligase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into peroxisome matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into peroxisome matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into peroxisome matrix, receptor recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of peroxisomal importomer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisome assembly protein 12
    Names
    peroxin-12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364762.1 → NP_001351691.1  peroxisome assembly protein 12

      Status: VALIDATED

      Source sequence(s)
      AK035552, AK041175
      Consensus CDS
      CCDS25160.1
      UniProtKB/Swiss-Prot
      Q8VC48
      UniProtKB/TrEMBL
      Q3TLN1, Q5SWQ8
      Related
      ENSMUSP00000103781.2, ENSMUST00000108146.8
      Conserved Domains (2) summary
      cd16451
      Location:304 → 345
      mRING_PEX12; Modified RING finger found in peroxin-12 (PEX12) and similar proteins
      pfam04757
      Location:26 → 267
      Pex2_Pex12; Pex2 / Pex12 amino terminal region

    2. NM_001364763.1 → NP_001351692.1  peroxisome assembly protein 12

      Status: VALIDATED

      Source sequence(s)
      AL603711
      Consensus CDS
      CCDS25160.1
      UniProtKB/Swiss-Prot
      Q8VC48
      UniProtKB/TrEMBL
      Q3TLN1, Q5SWQ8
      Related
      ENSMUSP00000135145.2, ENSMUST00000175741.8
      Conserved Domains (2) summary
      cd16451
      Location:304 → 345
      mRING_PEX12; Modified RING finger found in peroxin-12 (PEX12) and similar proteins
      pfam04757
      Location:26 → 267
      Pex2_Pex12; Pex2 / Pex12 amino terminal region

    3. NM_134025.4 → NP_598786.1  peroxisome assembly protein 12

      See identical proteins and their annotated locations for NP_598786.1

      Status: VALIDATED

      Source sequence(s)
      AK035552
      Consensus CDS
      CCDS25160.1
      UniProtKB/Swiss-Prot
      Q8VC48
      UniProtKB/TrEMBL
      Q3TLN1, Q5SWQ8
      Related
      ENSMUSP00000018877.3, ENSMUST00000018877.9
      Conserved Domains (2) summary
      cd16451
      Location:304 → 345
      mRING_PEX12; Modified RING finger found in peroxin-12 (PEX12) and similar proteins
      pfam04757
      Location:26 → 267
      Pex2_Pex12; Pex2 / Pex12 amino terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83182757..83189849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245454.2 → XP_030101314.1  peroxisome assembly protein 12 isoform X1

      UniProtKB/Swiss-Prot
      Q8VC48
      UniProtKB/TrEMBL
      Q3TLN1, Q5SWQ8
      Conserved Domains (2) summary
      cd16451
      Location:304 → 345
      mRING_PEX12; Modified RING finger found in peroxin-12 (PEX12) and similar proteins
      pfam04757
      Location:26 → 267
      Pex2_Pex12; Pex2 / Pex12 amino terminal region

    2. XM_030245453.2 → XP_030101313.1  peroxisome assembly protein 12 isoform X1

      UniProtKB/Swiss-Prot
      Q8VC48
      UniProtKB/TrEMBL
      Q3TLN1, Q5SWQ8
      Conserved Domains (2) summary
      cd16451
      Location:304 → 345
      mRING_PEX12; Modified RING finger found in peroxin-12 (PEX12) and similar proteins
      pfam04757
      Location:26 → 267
      Pex2_Pex12; Pex2 / Pex12 amino terminal region

    3. XM_030245452.2 → XP_030101312.1  peroxisome assembly protein 12 isoform X1

      UniProtKB/Swiss-Prot
      Q8VC48
      UniProtKB/TrEMBL
      Q3TLN1, Q5SWQ8
      Conserved Domains (2) summary
      cd16451
      Location:304 → 345
      mRING_PEX12; Modified RING finger found in peroxin-12 (PEX12) and similar proteins
      pfam04757
      Location:26 → 267
      Pex2_Pex12; Pex2 / Pex12 amino terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VC48.1 GenPept UniProtKB/Swiss-Prot:Q8VC48

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