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    Arl5b ADP-ribosylation factor-like 5B [ Mus musculus (house mouse) ]

    Gene ID: 75869, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Arl5bprovided by MGI
    Official Full Name
    ADP-ribosylation factor-like 5Bprovided by MGI
    Primary source
    MGI:MGI:1923119
    See related
    Ensembl:ENSMUSG00000017418 AllianceGenome:MGI:1923119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arl8; 4930587A11Rik
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport; protein localization to Golgi membrane; and vesicle-mediated transport. Predicted to be active in trans-Golgi network. Is expressed in testis. Orthologous to human ARL5B (ADP ribosylation factor like GTPase 5B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 9.2), whole brain E14.5 (RPKM 7.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 A2; 2 10.98 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (15060066..15087267)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (15055252..15082456)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta 2 subunit Neighboring gene STARR-seq mESC enhancer starr_03734 Neighboring gene TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_03735 Neighboring gene STARR-positive B cell enhancer ABC_E7794 Neighboring gene STARR-seq mESC enhancer starr_03736 Neighboring gene NOL1/NOP2/Sun domain family member 6 Neighboring gene STARR-seq mESC enhancer starr_03737 Neighboring gene STARR-seq mESC enhancer starr_03738 Neighboring gene peptidylprolyl isomerase D (cyclophilin D) pseudogene Neighboring gene STARR-seq mESC enhancer starr_03739 Neighboring gene STARR-seq mESC enhancer starr_03740 Neighboring gene STARR-seq mESC enhancer starr_03741 Neighboring gene STARR-seq mESC enhancer starr_03742 Neighboring gene predicted gene 13367

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B. Kitai Y, et al. J Biol Chem, 2015 Jan 9. PMID 25451939, Free PMC Article
    2. Isolation of a new member of the ADP-ribosylation like factor gene family, ARL8, from a cartilage cDNA library. Sebald E, et al. Gene, 2003 Jun 5. PMID 12853149
    3. Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. Vergnes L, et al. Cell Metab, 2013 Jun 4. PMID 23747249, Free PMC Article
    4. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    5. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results, therefore, suggest that Arl5B is a negative regulator for MDA5.
      Title: Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B.
    2. The expression pattern of the mouse ortholog Arl8 revealed differential tissue expression and an alternate transcript was seen in brain that was age-dependent.
      Title: Isolation of a new member of the ADP-ribosylation like factor gene family, ARL8, from a cartilage cDNA library.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 5B
    Names
    ADP-ribosylation factor-like 8
    ADP-ribosylation factor-like protein 8
    ADP-ribosylation-like factor 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029466.5 → NP_083742.3  ADP-ribosylation factor-like protein 5B

      Status: VALIDATED

      Source sequence(s)
      AL929268
      Consensus CDS
      CCDS15704.2
      UniProtKB/Swiss-Prot
      Q8BFU5, Q9D4P0
      UniProtKB/TrEMBL
      Q8BLF9
      Related
      ENSMUSP00000069725.5, ENSMUST00000069870.11
      Conserved Domains (1) summary
      cd04153
      Location:3 → 175
      Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      15060066..15087267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319316.3 → XP_017174805.1  ADP-ribosylation factor-like protein 5B isoform X1

      UniProtKB/TrEMBL
      Q8BLF9
      Conserved Domains (1) summary
      cl38936
      Location:1 → 138
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4P0.3 GenPept UniProtKB/Swiss-Prot:Q9D4P0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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