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    Ace2 angiotensin converting enzyme 2 [ Mus musculus (house mouse) ]

    Gene ID: 70008, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ace2provided by MGI
    Official Full Name
    angiotensin converting enzyme 2provided by MGI
    Primary source
    MGI:MGI:1917258
    See related
    Ensembl:ENSMUSG00000015405 AllianceGenome:MGI:1917258
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010305L05Rik
    Summary
    Predicted to enable identical protein binding activity; peptidase activity; and virus receptor activity. Involved in positive regulation of cardiac muscle contraction and tryptophan transport. Located in brush border membrane and cytoplasm. Is expressed in several structures, including brain; cardiovascular system; extraembryonic component; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 49.9), small intestine adult (RPKM 19.5) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X F5; X 76.12 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (162922338..162971414)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (164139342..164188418)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1986 Neighboring gene siah E3 ubiquitin protein ligase 1B Neighboring gene collectrin, amino acid transport regulator Neighboring gene STARR-seq mESC enhancer starr_48236 Neighboring gene BMX non-receptor tyrosine kinase Neighboring gene predicted gene, 19251 Neighboring gene STARR-seq mESC enhancer starr_48237 Neighboring gene predicted gene, 46692 Neighboring gene pirin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice. Nakagawasai O, et al. Mol Brain, 2023 Jun 13. PMID 37312182, Free PMC Article
    2. Intestinal ACE2 regulates glucose metabolism in diet-induced obese mice through a novel gut-islet axis mediated by tryptophan. Chen Q, et al. Obesity (Silver Spring), 2023 May. PMID 36998145
    3. Identification of the regulatory mechanism of ACE2 in COVID-19-induced kidney damage with systems genetics approach. Yang X, et al. J Mol Med (Berl), 2023 Apr. PMID 36951969, Free PMC Article
    4. Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection. Tang AT, et al. PLoS Biol, 2023 Feb. PMID 36745682, Free PMC Article
    5. A SARS-CoV-2-Related Virus from Malayan Pangolin Causes Lung Infection without Severe Disease in Human ACE2-Transgenic Mice. Liu MQ, et al. J Virol, 2023 Feb 28. PMID 36688655, Free PMC Article

    See all (297) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system.
      Title: Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system.
    2. ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression.
      Title: ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression.
    3. ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
      Title: ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
    4. Adaptation of SARS-CoV-2 to ACE2H353K mice reveals new spike residues that drive mouse infection.
      Title: Adaptation of SARS-CoV-2 to ACE2(H353K) mice reveals new spike residues that drive mouse infection.
    5. Generation and characterization of a humanized ACE2 mouse model to study long-term impacts of SARS-CoV-2 infection.
      Title: Generation and characterization of a humanized ACE2 mouse model to study long-term impacts of SARS-CoV-2 infection.
    6. Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells.
      Title: Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells.
    7. Lymphocytes regulate expression of the SARS-CoV-2 cell entry factor ACE2 in the pancreas of T2DM patients.
      Title: Lymphocytes regulate expression of the SARS-CoV-2 cell entry factor ACE2 in the pancreas of T2DM patients.
    8. Altered renin-angiotensin system gene expression in airways of antigen-challenged mice: ACE2 downregulation and unexpected increase in angiotensin 1-7.
      Title: Altered renin-angiotensin system gene expression in airways of antigen-challenged mice: ACE2 downregulation and unexpected increase in angiotensin 1-7.
    9. Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension.
      Title: Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension.
    10. Angiotensin deficient FVB/N mice are normotensive.
      Title: Angiotensin deficient FVB/N mice are normotensive.
    Submit: New GeneRIF Correction See all GeneRIFs (172)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxypeptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-dipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiotensin-mediated drinking behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in entry receptor-mediated virion attachment to host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of negative regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of L-proline import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gap junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor-mediated virion attachment to host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of systemic arterial blood pressure by renin-angiotensin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect symbiont entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tryptophan transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    angiotensin-converting enzyme 2
    Names
    ACE-related carboxypeptidase
    angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
    angiotensin I converting enzyme 2
    NP_001123985.1
    NP_081562.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130513.1 → NP_001123985.1  angiotensin-converting enzyme 2 precursor

      See identical proteins and their annotated locations for NP_001123985.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AK141604, BY722909
      Consensus CDS
      CCDS30518.1
      UniProtKB/Swiss-Prot
      Q8R0I0, Q99N70, Q99N71
      UniProtKB/TrEMBL
      C7ECU2, Q3URC9
      Related
      ENSMUSP00000107890.4, ENSMUST00000112271.10
      Conserved Domains (2) summary
      pfam01401
      Location:21 → 606
      Peptidase_M2; Angiotensin-converting enzyme
      pfam16959
      Location:617 → 770
      Collectrin; Renal amino acid transporter

    2. NM_027286.4 → NP_081562.2  angiotensin-converting enzyme 2 precursor

      See identical proteins and their annotated locations for NP_081562.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AI115946, AK141604
      Consensus CDS
      CCDS30518.1
      UniProtKB/Swiss-Prot
      Q8R0I0, Q99N70, Q99N71
      UniProtKB/TrEMBL
      C7ECU2, Q3URC9
      Related
      ENSMUSP00000073626.5, ENSMUST00000073973.11
      Conserved Domains (2) summary
      pfam01401
      Location:21 → 606
      Peptidase_M2; Angiotensin-converting enzyme
      pfam16959
      Location:617 → 770
      Collectrin; Renal amino acid transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      162922338..162971414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0I0.1 GenPept UniProtKB/Swiss-Prot:Q8R0I0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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