U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Adam28 a disintegrin and metallopeptidase domain 28 [ Mus musculus (house mouse) ]

    Gene ID: 13522, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Adam28provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 28provided by MGI
    Primary source
    MGI:MGI:105988
    See related
    Ensembl:ENSMUSG00000014725 AllianceGenome:MGI:105988
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MDCL; Dtgn1; MDC-L; eMDCII; TECADAM; C130072N01Rik; D430033C21Rik
    Summary
    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are typically membrane-anchored, although a form of this protein may be secreted. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a mature protein product. This protein may bind to integrins and regulate lymphocyte migration by enhancing cell adhesion. [provided by RefSeq, Aug 2015]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 58.0) See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    14 D1; 14 35.69 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (68842447..68893338, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (68604998..68655889, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37047 Neighboring gene predicted gene, 41191 Neighboring gene ADAM-like, decysin 1 Neighboring gene STARR-seq mESC enhancer starr_37048 Neighboring gene translation machinery-associated protein 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37049 Neighboring gene STARR-seq mESC enhancer starr_37050 Neighboring gene predicted gene, 46476 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69369284-69369585 Neighboring gene predicted gene, 31281

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Role for the metalloproteinase ADAM28 in the control of airway inflammation, remodelling and responsiveness in asthma. Bendavid G, et al. Front Immunol, 2022. PMID 36685493, Free PMC Article
    2. Modulation of integrin α4β1 by ADAM28 promotes lymphocyte adhesion and transendothelial migration. McGinn OJ, et al. Cell Biol Int, 2011 Oct. PMID 21332445
    3. Microenvironment-derived ADAM28 prevents cancer dissemination. Gérard C, et al. Oncotarget, 2018 Dec 14. PMID 30647853, Free PMC Article
    4. An ADAM family member with expression in thymic epithelial cells and related tissues. Haidl ID, et al. Gene, 2002 Jan 23. PMID 11867223
    5. Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28. Howard L, et al. Biochem J, 2000 May 15. PMID 10794709, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role for the metalloproteinase ADAM28 in the control of airway inflammation, remodelling and responsiveness in asthma.
      Title: Role for the metalloproteinase ADAM28 in the control of airway inflammation, remodelling and responsiveness in asthma.
    2. The results suggest that CD19 controls the differentiation of marginal zone precursors to marginal zone B cells by regulating ADAM28-mediated Notch2 cleavage.
      Title: CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells.
    3. The authors report that recombinant human MDC-L (ADAM 28) protein with the disintegrin domain binds to the alpha(4)beta(1) integrin, and this binding may regulate the interaction between lymphocytes and leukocytes expressing alpha(4)beta(1).
      Title: The lymphocyte metalloprotease MDC-L (ADAM 28) is a ligand for the integrin alpha4beta1.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 28
    Names
    ADAM 28
    a disintegrin and metalloprotease domain 28
    a disintegrin and metalloproteinase domain 28
    disintegrin 1
    metalloproteinase-disintegrin domain containing protein TECADAM
    thymic epithelial cell-ADAM
    NP_001041640.1
    NP_034212.1
    NP_899222.1
    XP_006518577.1
    XP_017171325.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048175.2 → NP_001041640.1  disintegrin and metalloproteinase domain-containing protein 28 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001041640.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) includes an alternate terminal 3' exon and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (4) has a distinct and shorter C-terminus, compared to isoform 1. It is not known whether this isoform (4) is proteolytically processed in the same manner as isoform 1.
      Source sequence(s)
      AK078982, AK136715, BB629805, CT025563
      Consensus CDS
      CCDS36964.1
      UniProtKB/TrEMBL
      Q71U12
      Related
      ENSMUSP00000106701.2, ENSMUST00000111072.8
      Conserved Domains (5) summary
      smart00608
      Location:496 → 623
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:206 → 400
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:419 → 491
      Disintegrin; Disintegrin
      pfam01421
      Location:206 → 402
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42 → 156
      Pep_M12B_propep; Reprolysin family propeptide

    2. NM_010082.2 → NP_034212.1  disintegrin and metalloproteinase domain-containing protein 28 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_034212.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK136715, BB629805, CT025563
      Consensus CDS
      CCDS36965.1
      UniProtKB/Swiss-Prot
      Q5D070, Q8K5D2, Q8K5D3, Q9JLN6
      UniProtKB/TrEMBL
      Q71U12
      Related
      ENSMUSP00000022642.6, ENSMUST00000022642.6
      Conserved Domains (5) summary
      smart00608
      Location:496 → 623
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:206 → 400
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:419 → 491
      Disintegrin; Disintegrin
      pfam01421
      Location:206 → 402
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42 → 156
      Pep_M12B_propep; Reprolysin family propeptide

    3. NM_183366.3 → NP_899222.1  disintegrin and metalloproteinase domain-containing protein 28 isoform 2 precursor

      See identical proteins and their annotated locations for NP_899222.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' exon, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter C-terminus, compared to isoform 1. It is not known whether this isoform (2) is proteolytically processed in the same manner as isoform 1.
      Source sequence(s)
      AK136715, BB629805, CT025563
      Consensus CDS
      CCDS88698.1
      UniProtKB/TrEMBL
      Q71U12
      Related
      ENSMUSP00000153354.2, ENSMUST00000224039.2
      Conserved Domains (5) summary
      smart00608
      Location:496 → 623
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:206 → 400
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:419 → 491
      Disintegrin; Disintegrin
      pfam01421
      Location:206 → 402
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:42 → 156
      Pep_M12B_propep; Reprolysin family propeptide

    RNA

    1. NR_102399.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal exon and uses an alternate 3' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK078982, AK136715, BB629805, CT025563

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      68842447..68893338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518514.4 → XP_006518577.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X1

      UniProtKB/TrEMBL
      Q71U12
      Conserved Domains (4) summary
      smart00608
      Location:496 → 623
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:206 → 400
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:419 → 491
      Disintegrin
      pfam01562
      Location:31 → 158
      Pep_M12B_propep; Reprolysin family propeptide

    2. XM_017315836.2 → XP_017171325.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X1

      UniProtKB/TrEMBL
      Q71U12
      Conserved Domains (4) summary
      smart00608
      Location:496 → 623
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:206 → 400
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:419 → 491
      Disintegrin
      pfam01562
      Location:31 → 158
      Pep_M12B_propep; Reprolysin family propeptide

    RNA

    1. XR_001781095.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_176991.1: Suppressed sequence

      Description
      NM_176991.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLN6.3 GenPept UniProtKB/Swiss-Prot:Q9JLN6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous