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    Vipr2 vasoactive intestinal peptide receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 22355, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Vipr2provided by MGI
    Official Full Name
    vasoactive intestinal peptide receptor 2provided by MGI
    Primary source
    MGI:MGI:107166
    See related
    Ensembl:ENSMUSG00000011171 AllianceGenome:MGI:107166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vip2; VPAC2; VPAC2R
    Summary
    Predicted to enable G protein-coupled peptide receptor activity; peptide hormone binding activity; and vasoactive intestinal polypeptide receptor activity. Predicted to be involved in activation of adenylate cyclase activity; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; and negative regulation of smooth muscle cell proliferation. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cilium. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; respiratory system; retina; and skeleton. Human ortholog(s) of this gene implicated in schizophrenia 16. Orthologous to human VIPR2 (vasoactive intestinal peptide receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 5.1), frontal lobe adult (RPKM 4.1) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 62.59 cM; 12 F2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (116041040..116117842)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (116077420..116148637)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E923 Neighboring gene zinc finger protein 386 (Kruppel-like) Neighboring gene predicted gene, 53772 Neighboring gene predicted gene, 46383 Neighboring gene predicted gene 20658 Neighboring gene STARR-positive B cell enhancer ABC_E8505 Neighboring gene STARR-seq mESC enhancer starr_33401 Neighboring gene predicted gene, 23732 Neighboring gene predicted gene, 46330

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Circadian Clock Is Sustained in the Thyroid Gland of VIP Receptor 2 Deficient Mice. Georg B, et al. Front Endocrinol (Lausanne), 2021. PMID 34539582, Free PMC Article
    2. Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice. Ago Y, et al. Neurobiol Learn Mem, 2017 Nov. PMID 29030297, Free PMC Article
    3. Cyclic AMP signaling control of action potential firing rate and molecular circadian pacemaking in the suprachiasmatic nucleus. Atkinson SE, et al. J Biol Rhythms, 2011 Jun. PMID 21628548
    4. Temporal phasing of locomotor activity, heart rate rhythmicity, and core body temperature is disrupted in VIP receptor 2-deficient mice. Hannibal J, et al. Am J Physiol Regul Integr Comp Physiol, 2011 Mar. PMID 21178124
    5. The absence of VPAC2 leads to aberrant antibody production in Aspergillus fumigatus sensitized and challenged mice. Samarasinghe AE, et al. Peptides, 2011 Jan. PMID 20923692, Free PMC Article

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gene deletion of the PACAP/VIP receptor, VPAC2R, alters glycemic responses during metabolic and psychogenic stress in adult female mice.
      Title: Gene deletion of the PACAP/VIP receptor, VPAC2R, alters glycemic responses during metabolic and psychogenic stress in adult female mice.
    2. VPAC1 and VPAC2 receptor deficiencies negatively influence pregnancy outcome through distinct and overlapping modulations of immune, trophoblast and vascular functions.
      Title: VPAC1 and VPAC2 receptor deficiencies negatively influence pregnancy outcome through distinct and overlapping modulations of immune, trophoblast and vascular functions.
    3. Dysfunction of VIPR2 leads to myopia in humans and mice.
      Title: Dysfunction of VIPR2 leads to myopia in humans and mice.
    4. The Circadian Clock Is Sustained in the Thyroid Gland of VIP Receptor 2 Deficient Mice.
      Title: The Circadian Clock Is Sustained in the Thyroid Gland of VIP Receptor 2 Deficient Mice.
    5. The Cell-Autonomous Clock of VIP Receptor VPAC2 Cells Regulates Period and Coherence of Circadian Behavior.
      Title: The Cell-Autonomous Clock of VIP Receptor VPAC2 Cells Regulates Period and Coherence of Circadian Behavior.
    6. The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit.
      Title: The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit.
    7. Spatiotemporal expression pattern of PERIOD 1 and PERIOD 2 in the mouse SCN is dependent on VIP receptor 2 signaling.
      Title: Spatiotemporal expression pattern of PERIOD 1 and PERIOD 2 in the mouse SCN is dependent on VIP receptor 2 signaling.
    8. Findings suggest that the vasoactive intestinal peptide receptor 2 plays an important role in the fear extinction processes and the regulation of the dendritic morphology in the prelimbic and infralimbic cortices.
      Title: Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice.
    9. PACAP/PAC1 signaling is important for light regulated behavior, VIP/VPAC2 signaling for stable clock function and both signaling pathways may play a role in shaping diurnality versus nocturnality.
      Title: PAC1- and VPAC2 receptors in light regulated behavior and physiology: Studies in single and double mutant mice.
    10. Results demonstrate critical protective roles for PACAP and the VPAC2 receptor against autoimmunity, promoting the expansion and maintenance of the Treg pool.
      Title: VPAC2 (vasoactive intestinal peptide receptor type 2) receptor deficient mice develop exacerbated experimental autoimmune encephalomyelitis with increased Th1/Th17 and reduced Th2/Treg responses.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vasoactive intestinal polypeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables vasoactive intestinal polypeptide receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vasoactive intestinal polypeptide receptor 2
    Names
    PACAP type III receptor
    PACAP-R-3
    PACAP-R3
    VIP receptor subtype 2
    VIP-R-2
    VPAC2 receptor
    pituitary adenylate cyclase-activating polypeptide type III receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001422975.1 → NP_001409904.1  vasoactive intestinal polypeptide receptor 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC105950, AC243430

    2. NM_009511.2 → NP_033537.1  vasoactive intestinal polypeptide receptor 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_033537.1

      Status: VALIDATED

      Source sequence(s)
      AA028630, AI894015, AK038743, BC138572, BU920841, CO044818, D28132
      Consensus CDS
      CCDS26210.1
      UniProtKB/Swiss-Prot
      P41588, P97750
      UniProtKB/TrEMBL
      Q546Q8
      Related
      ENSMUSP00000011315.4, ENSMUST00000011315.10
      Conserved Domains (2) summary
      smart00008
      Location:47 → 117
      HormR; Domain present in hormone receptors
      pfam00002
      Location:122 → 370
      7tm_2; 7 transmembrane receptor (Secretin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      116041040..116117842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244102.3 → XP_011242404.1  vasoactive intestinal polypeptide receptor 2 isoform X3

      Conserved Domains (2) summary
      smart00008
      Location:47 → 117
      HormR; Domain present in hormone receptors
      cd15986
      Location:122 → 382
      7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    2. XM_017315043.3 → XP_017170532.1  vasoactive intestinal polypeptide receptor 2 isoform X1

      Conserved Domains (2) summary
      smart00008
      Location:47 → 117
      HormR; Domain present in hormone receptors
      cd15986
      Location:122 → 382
      7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    3. XM_006515806.4 → XP_006515869.1  vasoactive intestinal polypeptide receptor 2 isoform X4

      Conserved Domains (2) summary
      smart00008
      Location:47 → 117
      HormR; Domain present in hormone receptors
      cd15986
      Location:122 → 380
      7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

    4. XM_017315044.3 → XP_017170533.1  vasoactive intestinal polypeptide receptor 2 isoform X5

      Conserved Domains (2) summary
      cd14964
      Location:34 → 61
      7tm_GPCRs; TM helix 3 [structural motif]
      cl28897
      Location:1 → 222
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41588.1 GenPept UniProtKB/Swiss-Prot:P41588

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