Taf7l TATA-box binding protein associated factor 7 like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taf7lprovided by MGI
Official Full Name: TATA-box binding protein associated factor 7 likeprovided by MGI
Primary source: MGI:MGI:1921719
See related: Ensembl:ENSMUSG00000009596 AllianceGenome:MGI:1921719
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Taf2q; 4933438I11Rik
Summary: Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Acts upstream of or within flagellated sperm motility and spermatid development. Located in cytoplasm and nucleus. Is expressed in bladder; brown fat; ovary; testis; and ureter. Orthologous to human TAF7L (TATA-box binding protein associated factor 7 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward placenta adult (RPKM 21.3) See more
Orthologs: human all
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Genomic context

Location:: X E3; X 56.18 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (133360865..133377254, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (134460116..134476505, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mouse D144G substitution is analogous to a missense mutation (D136G) in the X-linked TAF7L gene identified in oligozoospermic men. Although the D144G substitution in mouse does not affect male fertility, RNA-seq analyses revealed alterations in transcriptome profiles in the Taf7l (D144G) mutant testes.
Title: Genetic characterization of a missense mutation in the X-linked TAF7L gene identified in an oligozoospermic man†.
Taf7l (Taf2q) is a gene that is expressed in testis that was identified in a genome-wide cDNA subtraction screen.
Title: An abundance of X-linked genes expressed in spermatogonia.
Genes expressed in germ cells, like Taf7l (Taf2q), are subject to meiotic sex-chromosome inactivation (MSCI) during spermatogenesis.
Title: Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse.
Suggest that TAF7L plays an integral role in adipocyte gene expression by targeting enhancers as a cofactor for PPARgamma and promoters as a component of the core transcriptional machinery.
Title: Dual functions of TAF7L in adipocyte differentiation.
the presence of the tissue-specific TAF7L subunit in TFIID functions to promote long-range chromatin interactions during brown adipose tissue lineage specification
Title: TAF7L modulates brown adipose tissue formation.
TAF7L associates with TRF2 both in vitro and in testis, suggesting that TAF7L likely cooperates directly with TRF2 at promoters of a subset of postmeiotic genes to regulate spermiogenesis.
Title: Taf7l cooperates with Trf2 to regulate spermiogenesis.
Transcripts highly enriched in neonatal ovaries.
Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.
While spermatogenesis was completed in Taf7l(-/Y) mice, the weight of Taf7l(-/Y) testis decreased. Mutant epididymal sperm exhibited abnormal morphology. Sperm motility was significantly reduced, and Taf7l(-/Y) males were fertile with reduced litter size.
Title: Abnormal sperm in mice lacking the Taf7l gene.
TAF7L replaces TAF7 as a TFIID subunit in late pachytene spermatocytes and in haploid cells.
Title: The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation.
Disruption of Taf7l causes reduced testis weight, decreased sperm production and motility, and abnormal morphology
Title: Abnormal sperm in mice lacking the Taf7l gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489249

G65211 (e-PCR)
- UniSTS:225880

G65785 (e-PCR)
- UniSTS:225922

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
NOT located_in chromocenter	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription initiation factor TFIID subunit 7-like

Names: TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor; TATA box binding protein (TBP)-associated factor, RNA polymerase II, Q; TATA box binding protein-associated factor RNA polymerase II subunit Q; TATA box-binding protein-associated factor 50 kDa; transcription initiation factor TFIID 50 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028958.4 → NP_083234.2 transcription initiation factor TFIID subunit 7-like

See identical proteins and their annotated locations for NP_083234.2

Status: VALIDATED

Source sequence(s)

AK017109, AW553087, BB871901

Consensus CDS

CCDS53184.1

UniProtKB/Swiss-Prot

A2AFB9, Q99MW7, Q9D3R9

Related

ENSMUSP00000009740.3, ENSMUST00000009740.9

Conserved Domains (1) summary

pfam04658
Location:106 → 285

TAFII55_N; TAFII55 protein conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

133360865..133377254 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528610.4 → XP_006528673.1 transcription initiation factor TFIID subunit 7-like isoform X1

Conserved Domains (2) summary

PHA03291
Location:7 → 86

PHA03291; envelope glycoprotein I; Provisional

pfam04658
Location:106 → 249

TAFII55_N; TAFII55 protein conserved region
XM_006528611.4 → XP_006528674.1 transcription initiation factor TFIID subunit 7-like isoform X2

Conserved Domains (1) summary

pfam04658
Location:21 → 200

TAFII55_N; TAFII55 protein conserved region
XM_006528613.4 → XP_006528676.1 transcription initiation factor TFIID subunit 7-like isoform X3

UniProtKB/TrEMBL

B1AV36

Related

ENSMUSP00000108849.3, ENSMUST00000113223.3

Conserved Domains (1) summary

pfam04658
Location:21 → 164

TAFII55_N; TAFII55 protein conserved region
XM_006528615.4 → XP_006528678.1 transcription initiation factor TFIID subunit 7-like isoform X4

Conserved Domains (1) summary

cl04653
Location:41 → 57

TAF7; TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex