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    Ddah2 DDAH family member 2, ADMA independent [ Mus musculus (house mouse) ]

    Gene ID: 51793, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ddah2provided by MGI
    Official Full Name
    DDAH family member 2, ADMA independentprovided by MGI
    Primary source
    MGI:MGI:1859016
    See related
    Ensembl:ENSMUSG00000007039 AllianceGenome:MGI:1859016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G6a; Ddah; NG30; DDAH-2; DDAHII; 1110003M04Rik
    Summary
    Predicted to enable amino acid binding activity and dimethylargininase activity. Predicted to be involved in arginine metabolic process; citrulline metabolic process; and positive regulation of nitric oxide biosynthetic process. Predicted to act upstream of or within arginine catabolic process. Predicted to be located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human DDAH2 (dimethylarginine dimethylaminohydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 135.9), CNS E14 (RPKM 77.7) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ddah2 in Genome Data Viewer
    Location:
    17 B1; 17 18.59 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35278011..35281075)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35059035..35062099)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23421 Neighboring gene STARR-seq mESC enhancer starr_42445 Neighboring gene chloride intracellular channel 1 Neighboring gene STARR-positive B cell enhancer ABC_E11641 Neighboring gene megakaryocyte and platelet inhibitory receptor G6b Neighboring gene G6b opposite strand Neighboring gene lymphocyte antigen 6 family member G6C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase. Ragavan VN, et al. Nat Commun, 2023 Jun 9. PMID 37296100, Free PMC Article
    2. DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission. Huang S, et al. Sci Signal, 2021 Apr 13. PMID 33850055
    3. DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats. Zhu ZD, et al. Int J Mol Med, 2019 Feb. PMID 30569164, Free PMC Article
    4. Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2. Hasegawa K, et al. Circ Res, 2007 Jul 20. PMID 17601800
    5. Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation. Xie Z, et al. Nat Commun, 2022 Jan 10. PMID 35013196, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase.
      Title: A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase.
    2. DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission.
      Title: DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission.
    3. the overexpression of DDAH2 attenuates myocardial fibrosis and protects against Diabetic cardiomyopathy DCM through activation of the DDAH/ADMA/NOS/NO pathway
      Title: DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats.
    4. We conclude that pp60(Src) can directly inhibit DDAH II and this is involved in the increased ADMA levels that enhance eNOS uncoupling during the development of acute lung injury (ALI).
      Title: Hyper-activation of pp60(Src) limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury.
    5. In mild CKD, dysregulation of the ADMA/DDAH pathway in adipose tissue triggers lipodystrophy-like phenotype changes, including ectopic fat depositions.
      Title: The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats.
    6. The Sirt1/DDAH2/secretagogin pathway is a novel regulator of glucose-stimulated insulin secretion.
      Title: The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice.
    7. ADMA and nitrosative stress are related to increased expression of protein-arginine methyltransferase-2, an ADMA-synthesizing enzyme, and reduced expression of dimethylarginine dimethylaminohydrolase-2, an ADMA-degrading enzyme, in bronchial epithelia
      Title: Altered asymmetric dimethyl arginine metabolism in allergically inflamed mouse lungs.
    8. Results show that asymmetric methylarginine increases pulmonary endothelial permeability, and that its effects on permeability, Rac1 activation and VASP phosphorylation are prevented by overexpression of active DDAHI and DDAHII.
      Title: Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function.
    9. Report tissue-specific downregulation of DDAH2 in hyperhomocysteinemia.
      Title: Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.
    10. DDAH2/ADMA pathway can be a novel therapeutic target for vasculopathy in the ADMA or angiotensin II-induced pathophysiological conditions
      Title: Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables dimethylargininase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    putative hydrolase DDAH2
    Names
    Clone 7u
    N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
    dimethylargininase-2
    dimethylarginine dimethylaminohydrolase 2
    inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
    inactive dimethylarginine dimethylaminohydrolase 2
    NP_001177378.1
    NP_058045.1
    XP_006524675.1
    XP_030105756.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190449.1 → NP_001177378.1  putative hydrolase DDAH2 isoform 1

      See identical proteins and their annotated locations for NP_001177378.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC087117
      Consensus CDS
      CCDS50082.1
      UniProtKB/Swiss-Prot
      Q99LD8
      Related
      ENSMUSP00000007255.7, ENSMUST00000007255.13
      Conserved Domains (1) summary
      cl19186
      Location:62 → 277
      Amidinotransf; Amidinotransferase

    2. NM_016765.3 → NP_058045.1  putative hydrolase DDAH2 isoform 2

      See identical proteins and their annotated locations for NP_058045.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC087117
      Consensus CDS
      CCDS57070.1
      UniProtKB/TrEMBL
      O08972
      Related
      ENSMUSP00000134072.2, ENSMUST00000174493.8
      Conserved Domains (1) summary
      cl19186
      Location:62 → 166
      Amidinotransf; Amidinotransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35278011..35281075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524612.5 → XP_006524675.1  putative hydrolase DDAH2 isoform X1

      See identical proteins and their annotated locations for XP_006524675.1

      UniProtKB/Swiss-Prot
      Q99LD8
      Conserved Domains (1) summary
      cl19186
      Location:62 → 277
      Amidinotransf; Amidinotransferase

    2. XM_030249896.2 → XP_030105756.1  putative hydrolase DDAH2 isoform X2

      UniProtKB/TrEMBL
      O08972
      Conserved Domains (1) summary
      cl19186
      Location:62 → 166
      Amidinotransf; Amidinotransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LD8.1 GenPept UniProtKB/Swiss-Prot:Q99LD8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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