Acot13 acyl-CoA thioesterase 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acot13provided by MGI
Official Full Name: acyl-CoA thioesterase 13provided by MGI
Primary source: MGI:MGI:1914084
See related: Ensembl:ENSMUSG00000006717 AllianceGenome:MGI:1914084
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Them2; 0610006O17Rik
Summary: Predicted to enable acyl-CoA hydrolase activity. Involved in negative regulation of cold-induced thermogenesis. Located in mitochondrial matrix. Is expressed in chondrocranium; hindgut; and midgut. Orthologous to human ACOT13 (acyl-CoA thioesterase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 114.5), kidney adult (RPKM 88.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.1; 13 10.69 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (25001938..25015472, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (24817955..24831489, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Up-regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice.
Title: Up-regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice.
t a pathogenic role of Them2 in the biosynthesis of glycerolipid metabolites that promote hepatic insulin resistance
Title: Thioesterase superfamily member 2 promotes hepatic insulin resistance in the setting of glycerol-3-phosphate acyltransferase 1-induced steatosis.
These findings reveal a primary role for Them2 in promoting mitochondrial oxidation of fatty acids and glucose in the liver.
Title: Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization.
PC-TP-THEM2 complex reduces phosphorylation and stability of IRS2 and increases stability of the TSC1-TSC2 complex
Title: Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling.
Them2 functions in brown adipose tissue to suppress adaptive increases in energy expenditure.
Title: Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice.
Yeast two-hybrid screening using libraries prepared from mouse liver and embryo identified Them2 (thioesterase superfamily member 2) and the homeodomain transcription factor Pax3 (paired box gene 3), respectively, as PC-TP-interacting proteins.
Title: Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acyl-coenzyme A thioesterase 13

Names: hotdog-fold thioesterase superfamily member 2; palmitoyl-CoA hydrolase; thioesterase superfamily member 2

NP_080066.1

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025790.2 → NP_080066.1 acyl-coenzyme A thioesterase 13

See identical proteins and their annotated locations for NP_080066.1

Status: PROVISIONAL

Source sequence(s)

AK002261

Consensus CDS

CCDS26380.1

UniProtKB/Swiss-Prot

Q9CQR4

UniProtKB/TrEMBL

Q4VA32

Related

ENSMUSP00000006900.7, ENSMUST00000006900.7

Conserved Domains (1) summary

cd03443
Location:28 → 138

PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...