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    Cabp5 calcium binding protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 29865, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Cabp5provided by MGI
    Official Full Name
    calcium binding protein 5provided by MGI
    Primary source
    MGI:MGI:1352746
    See related
    Ensembl:ENSMUSG00000005649 AllianceGenome:MGI:1352746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be located in cytosol. Is expressed in ovary; stomach; and testis. Orthologous to human CABP5 (calcium binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A1; 7 7.87 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (13119885..13142812)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13385960..13408887)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group IVC (cytosolic, calcium-independent) Neighboring gene ribosomal protein S8, pseudogene 4 Neighboring gene phospholipase A2, group IVC (cytosolic, calcium-independent), pseudogene Neighboring gene STARR-seq mESC enhancer starr_18079 Neighboring gene ribosomal protein L7A, pseudogene 14 Neighboring gene binder of sperm protein homolog 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of Ca2+-binding protein 5 knockout mouse retina. Rieke F, et al. Invest Ophthalmol Vis Sci, 2008 Nov. PMID 18586882, Free PMC Article
    2. Insight into the role of Ca2+-binding protein 5 in vesicle exocytosis. Sokal I, et al. Invest Ophthalmol Vis Sci, 2011 Nov 25. PMID 22039235, Free PMC Article
    3. Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). Sokal I, et al. Biochim Biophys Acta, 2000 Dec 20. PMID 11108966
    4. The transcription factor Bhlhb4 is required for rod bipolar cell maturation. Bramblett DE, et al. Neuron, 2004 Sep 16. PMID 15363390
    5. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. Haeseleer F, et al. J Biol Chem, 2000 Jan 14. PMID 10625670, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-binding protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418438.1 → NP_001405367.1  calcium-binding protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156985

    2. NM_001418448.1 → NP_001405377.1  calcium-binding protein 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC156985
      UniProtKB/TrEMBL
      D3YWT5
      Related
      ENSMUSP00000112415.2, ENSMUST00000117400.2

    3. NM_013877.4 → NP_038905.1  calcium-binding protein 5 isoform 1

      See identical proteins and their annotated locations for NP_038905.1

      Status: VALIDATED

      Source sequence(s)
      AC156985
      Consensus CDS
      CCDS20831.1
      UniProtKB/Swiss-Prot
      Q9JLK3
      UniProtKB/TrEMBL
      Q543X4
      Related
      ENSMUSP00000005791.8, ENSMUST00000005791.14
      Conserved Domains (2) summary
      PTZ00184
      Location:25 → 171
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:109 → 172
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RNA

    1. NR_184745.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156985

    2. NR_184746.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156985

    3. NR_184747.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156985

    4. NR_184748.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156985

    5. NR_184749.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156985

    6. NR_184750.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156985

    7. NR_184751.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156985

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      13119885..13142812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322297.1 → XP_017177786.1  calcium-binding protein 5 isoform X1

      Conserved Domains (1) summary
      PTZ00184
      Location:8 → 154
      PTZ00184; calmodulin; Provisional

    2. XM_017322298.2 → XP_017177787.1  calcium-binding protein 5 isoform X1

      Conserved Domains (1) summary
      PTZ00184
      Location:8 → 154
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLK3.1 GenPept UniProtKB/Swiss-Prot:Q9JLK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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