U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Evx1 even-skipped homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 14028, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Evx1provided by MGI
    Official Full Name
    even-skipped homeobox 1provided by MGI
    Primary source
    MGI:MGI:95461
    See related
    Ensembl:ENSMUSG00000005503 AllianceGenome:MGI:95461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Evx-1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryo development; generation of neurons; and positive regulation of transcription by RNA polymerase II. Located in axon and cell body. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; genitourinary system; and limb bud. Orthologous to human EVX1 (even-skipped homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 1.7), ovary adult (RPKM 1.2) and 8 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    6 B3; 6 25.44 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (52290483..52295374)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (52313498..52318389)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene homeobox A13 Neighboring gene Hoxa distal transcript antisense RNA Neighboring gene STARR-seq mESC enhancer starr_15903 Neighboring gene even skipped homeotic gene 1, opposite strand Neighboring gene VISTA enhancer mm1524 Neighboring gene ribosomal protein L38 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15904 Neighboring gene VISTA enhancer mm48 Neighboring gene RIKEN cDNA 1700094M24 gene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. Spyropoulos DD, et al. Genes Dev, 1994 Aug 15. PMID 7958869
    2. Activation of the cytotactin promoter by the homeobox-containing gene Evx-1. Jones FS, et al. Proc Natl Acad Sci U S A, 1992 Mar 15. PMID 1372434, Free PMC Article
    3. The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation. Bell CC, et al. Sci Rep, 2016 May 26. PMID 27226347, Free PMC Article
    4. FGF-4 regulates expression of Evx-1 in the developing mouse limb. Niswander L, et al. Development, 1993 Sep. PMID 7506139
    5. Isolation and mapping of EVX1, a human homeobox gene homologous to even-skipped, localized at the 5' end of HOX1 locus on chromosome 7. Faiella A, et al. Nucleic Acids Res, 1991 Dec 11. PMID 1684419, Free PMC Article

    See all (128) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evx1as has no function independent of EVX1, and is therefore unlikely to act in trans.
      Title: The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within interneuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spinal cord interneuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    homeobox even-skipped homolog protein 1
    Names
    even skipped homeotic gene 1 homolog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007966.4 → NP_031992.1  homeobox even-skipped homolog protein 1

      See identical proteins and their annotated locations for NP_031992.1

      Status: VALIDATED

      Source sequence(s)
      AC113985
      Consensus CDS
      CCDS20149.1
      UniProtKB/Swiss-Prot
      P23683
      Related
      ENSMUSP00000031787.8, ENSMUST00000031787.8
      Conserved Domains (1) summary
      smart00389
      Location:183 → 239
      HOX; Homeodomain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      52290483..52295374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505516.1 → XP_006505579.1  homeobox even-skipped homolog protein 1 isoform X1

      Conserved Domains (1) summary
      pfam00046
      Location:5 → 58
      Homeobox; Homeobox domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23683.1 GenPept UniProtKB/Swiss-Prot:P23683

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous