Adgre1 adhesion G protein-coupled receptor E1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adgre1provided by MGI
Official Full Name: adhesion G protein-coupled receptor E1provided by MGI
Primary source: MGI:MGI:106912
See related: Ensembl:ENSMUSG00000004730 AllianceGenome:MGI:106912
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Emr1; Ly71; F4/80; Gpf480; TM7LN3; DD7A5-7; EGF-TM7
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and adaptive immune response. Located in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; hemolymphoid system; and intestine. Orthologous to human ADGRE1 (adhesion G protein-coupled receptor E1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 13.7), mammary gland adult (RPKM 11.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 D; 17 29.8 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (57665650..57790527)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (57358581..57483529)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EMR1 expression is restricted to mature blood and tissue eosinophils. Targeting of eosinophils with afucosylated anti-EMR1 antibody shows promise as a treatment for eosinophilic disorders.
Title: The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders.
F4/80-expressing necrotic tumor cell-derived monocytes induce apoptosis of activated T cells but not nonstimulated T cells.
Title: Tumor cell-released TLR4 ligands stimulate Gr-1+CD11b+F4/80+ cells to induce apoptosis of activated T cells.
CD11b and F4/80 appear to participate in conjunctival eosinophil infiltration in allergic conjunctivitis.
Title: Participation of CD11b and F4/80 molecules in the conjunctival eosinophilia of experimental allergic conjunctivitis.
Flow analysis indicated little overlap between the F4/80 and CSF-1R-positive populations in peritoneal macrophage.
Title: Inducible transgenes under the control of the hCD68 promoter identifies mouse macrophages with a distribution that differs from the F4/80 - and CSF-1R-expressing populations.
c-Maf is required for the F4/80 expression in macrophages in vivo.
Title: c-Maf is essential for the F4/80 expression in macrophages in vivo.
Data show that total cell number and immune function of F4/80+ macrophages are decreased in diabetic mice, and this may play a role in increased macrophage-related complications in diabetic patients.
Title: Diabetes-induced alteration of F4/80+ macrophages: a study in mice with streptozotocin-induced diabetes for a long term.
Expression of CCR2 and F4/80 increased after ethanol feeding in WT mice, but such increase was less evident in H-STAT3KO mice.
Title: Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury.
These results demonstrate that MafB is essential for podocyte differentiation, renal tubule survival, and F4/80 maturation in a distinct subpopulation of nonadherent mature macrophages.
Title: MafB is essential for renal development and F4/80 expression in macrophages.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Chemically induced (ENU) (4)
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

X93328 (e-PCR)
- UniSTS:163593

U66888 (e-PCR)
- UniSTS:181038

Emr1 (e-PCR), detects polymorphism
- UniSTS:470616

X93328 (e-PCR)
- UniSTS:160674

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adhesion G protein-coupled receptor E1

Names: EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; cell surface glycoprotein F4/80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355722.2 → NP_001342651.1 adhesion G protein-coupled receptor E1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

CT010434

Consensus CDS

CCDS50160.1

UniProtKB/Swiss-Prot

Q61549

UniProtKB/TrEMBL

Q3U1M9, Q3U9R0

Related

ENSMUSP00000004850.8, ENSMUST00000004850.8

Conserved Domains (4) summary

smart00303
Location:591 → 640

GPS; G-protein-coupled receptor proteolytic site domain

smart00179
Location:133 → 172

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:222 → 258

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd15439
Location:644 → 906

7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
NM_001355723.2 → NP_001342652.1 adhesion G protein-coupled receptor E1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

CT010434

UniProtKB/TrEMBL

Q3U1M9

Conserved Domains (5) summary

smart00303
Location:575 → 624

GPS; G-protein-coupled receptor proteolytic site domain

smart00179
Location:117 → 156

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:206 → 242

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam16489
Location:420 → 549

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cd15439
Location:628 → 890

7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
NM_001424712.1 → NP_001411641.1 adhesion G protein-coupled receptor E1 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

CT010434
NM_010130.5 → NP_034260.1 adhesion G protein-coupled receptor E1 isoform 1 precursor

See identical proteins and their annotated locations for NP_034260.1

Status: VALIDATED

Source sequence(s)

CT010434

Consensus CDS

CCDS50160.1

UniProtKB/Swiss-Prot

Q61549

UniProtKB/TrEMBL

Q3U1M9, Q3U9R0

Related

ENSMUSP00000083971.6, ENSMUST00000086763.13

Conserved Domains (4) summary

smart00303
Location:591 → 640

GPS; G-protein-coupled receptor proteolytic site domain

smart00179
Location:133 → 172

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:222 → 258

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd15439
Location:644 → 906

7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

57665650..57790527

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160297.1 → XP_036016190.1 adhesion G protein-coupled receptor E1 isoform X1

UniProtKB/TrEMBL

Q3U1M9

Conserved Domains (4) summary

smart00303
Location:552 → 601

GPS; G-protein-coupled receptor proteolytic site domain

smart00179
Location:133 → 172

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:222 → 258

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd15439
Location:605 → 867

7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors