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    Kpna6 karyopherin subunit alpha 6 [ Mus musculus (house mouse) ]

    Gene ID: 16650, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Kpna6provided by MGI
    Official Full Name
    karyopherin subunit alpha 6provided by MGI
    Primary source
    MGI:MGI:1100836
    See related
    Ensembl:ENSMUSG00000003731 AllianceGenome:MGI:1100836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IPOA7; Kpna5; NPI-2
    Summary
    Enables nuclear import signal receptor activity. Acts upstream of or within several processes, including entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of macromolecule metabolic process; and protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in several structures, including heart; liver; lung; oocyte; and spleen. Orthologous to human KPNA6 (karyopherin subunit alpha 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 30.4), subcutaneous fat pad adult (RPKM 16.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.2; 4 63.28 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129537772..129566560, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129643979..129672767, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10261 Neighboring gene STARR-seq mESC enhancer starr_11504 Neighboring gene coiled coil domain containing 28B Neighboring gene predicted gene, 34305 Neighboring gene taxilin alpha Neighboring gene STARR-positive B cell enhancer ABC_E1283 Neighboring gene STARR-positive B cell enhancer ABC_E7992 Neighboring gene transmembrane protein 39b Neighboring gene microRNA 7016 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129378925-129379108 Neighboring gene KH domain containing, RNA binding, signal transduction associated 1 Neighboring gene STARR-seq mESC enhancer starr_11505

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis. Liu N, et al. Development, 2021 Oct 1. PMID 34473250, Free PMC Article
    2. Importin-α7 Is Involved in the Formation of Ebola Virus Inclusion Bodies but Is Not Essential for Pathogenicity in Mice. Gabriel G, et al. J Infect Dis, 2015 Oct 1. PMID 26185094, Free PMC Article
    3. Importin-α7 is required for enhanced influenza A virus replication in the alveolar epithelium and severe lung damage in mice. Resa-Infante P, et al. J Virol, 2014 Jul. PMID 24829333, Free PMC Article
    4. Identification of importin α 7 specific transport cargoes using a proteomic screening approach. Hügel S, et al. Mol Cell Proteomics, 2014 May. PMID 24623588, Free PMC Article
    5. Involvement of classical bipartite/karyopherin nuclear import pathway components in acrosomal trafficking and assembly during bovine and murid spermiogenesis. Tran MH, et al. Biol Reprod, 2012 Mar. PMID 22156475

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis.
      Title: Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis.
    2. Data shows that Importin 7 binds many partners from ovary that alpha are involved in RNA processing, chromosome organization, and chromatin modification.
      Title: Identification of importin α 7 specific transport cargoes using a proteomic screening approach.
    3. Importin alpha7 is a new member of the small group of maternal effect genes.
      Title: Importin α7 is essential for zygotic genome activation and early mouse development.
    4. Overexpression of Kpna6 facilitates Keap1 nuclear import and attenuates Nrf2 signaling, whereas knockdown of Kpna6 slows down Keap1 nuclear import and enhances the Nrf2-mediated adaptive response induced by oxidative stress.
      Title: KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within maternal process involved in female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of viral life cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of viral life cycle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within symbiont-mediated perturbation of host defenses IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NLS-dependent protein nuclear import complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    importin subunit alpha-7
    Names
    importin alpha 7
    importin alpha-S2
    karyopherin (importin) alpha 5
    karyopherin (importin) alpha 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008468.4 → NP_032494.3  importin subunit alpha-7

      See identical proteins and their annotated locations for NP_032494.3

      Status: VALIDATED

      Source sequence(s)
      AK046371, AL671759, CJ082540
      Consensus CDS
      CCDS18701.1
      UniProtKB/Swiss-Prot
      O35345, Q3U388, Q9CVP9
      UniProtKB/TrEMBL
      Q4FJZ2, Q8BH30
      Related
      ENSMUSP00000099650.5, ENSMUST00000102590.11
      Conserved Domains (5) summary
      COG5064
      Location:36 → 525
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:251 → 365
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:9 → 102
      IBB; Importin beta binding domain
      pfam16186
      Location:464 → 508
      Arm_3; Atypical Arm repeat
      sd00043
      Location:254 → 279
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129537772..129566560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502814.4 → XP_006502877.1  importin subunit alpha-7 isoform X1

      See identical proteins and their annotated locations for XP_006502877.1

      UniProtKB/TrEMBL
      Q4FJZ2
      Related
      ENSMUSP00000003828.5, ENSMUST00000003828.11
      Conserved Domains (2) summary
      COG5064
      Location:41 → 530
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:259 → 284
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35345.2 GenPept UniProtKB/Swiss-Prot:O35345

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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