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    Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 [ Mus musculus (house mouse) ]

    Gene ID: 72054, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Cyp4f18provided by MGI
    Official Full Name
    cytochrome P450, family 4, subfamily f, polypeptide 18provided by MGI
    Primary source
    MGI:MGI:1919304
    See related
    Ensembl:ENSMUSG00000003484 AllianceGenome:MGI:1919304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyp4f3; Cypf18; CYPIVF3; 1810054N16Rik
    Summary
    Predicted to enable monooxygenase activity. Predicted to be involved in monocarboxylic acid metabolic process and quinone catabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human CYP4F3 (cytochrome P450 family 4 subfamily F member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 31.6), mammary gland adult (RPKM 9.0) and 13 other tissues See more
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    Genomic context

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    Location:
    8 B3.3; 8 34.67 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72742326..72763512, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71988482..72009668, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10511 Neighboring gene zinc finger protein 617 Neighboring gene STARR-positive B cell enhancer ABC_E3784 Neighboring gene STARR-seq mESC enhancer starr_21836 Neighboring gene zinc finger protein 961 Neighboring gene STARR-seq mESC enhancer starr_21837 Neighboring gene STARR-seq mESC enhancer starr_21838 Neighboring gene predicted gene, 51535 Neighboring gene predicted gene 45734 Neighboring gene gem (nuclear organelle) associated protein 8 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic deletion of Cyp4f18 disrupts the omega-3 epoxidation pathway and results in psoriasis-like dermatitis. Yoshida M, et al. FASEB J, 2022 Dec. PMID 36374250
    2. Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice. Wu J, et al. Kidney Blood Press Res, 2021. PMID 34320496
    3. CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a. Vaivoda R, et al. J Immunol Res, 2015. PMID 26613087, Free PMC Article
    4. Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemia. Winslow V, et al. Biochim Biophys Acta, 2014 Jun. PMID 24632148, Free PMC Article
    5. The cytochromes P450 (CYP) response to allergic inflammation of the lung. Stoilov I, et al. Arch Biochem Biophys, 2006 Dec 1. PMID 17081494

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic deletion of Cyp4f18 disrupts the omega-3 epoxidation pathway and results in psoriasis-like dermatitis.
      Title: Genetic deletion of Cyp4f18 disrupts the omega-3 epoxidation pathway and results in psoriasis-like dermatitis.
    2. Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice.
      Title: Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice.
    3. CYP4F18-deficient neutrophils exhibit increased chemotaxis to complement component C5a.
      Title: CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a.
    4. It is concluded that CYP4F18 is necessary for omega oxidation of leukotriene B4 in neutrophils, and is not compensated by other CYP enzymes
      Title: Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemia.
    5. The mRNA levels of Cyp4f18 increase with the development of allergic inflammation in the lung.
      Title: The cytochromes P450 (CYP) response to allergic inflammation of the lung.
    6. CYP4F18 is a critical protein in the regulation of LTB(4) metabolism
      Title: Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 20-aldehyde-leukotriene B4 20-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 20-hydroxy-leukotriene B4 omega oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alkane 1-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-tocopherol omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonic acid epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonic acid omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene-B4 20-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid omega-1 hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid omega-1 hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tocotrienol omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables very long-chain fatty acid omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in leukotriene B4 metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4F3
    Names
    cytochrome P450 CYP4F18
    cytochrome P450, 4f18
    cytochrome P450-LTB-omega
    leukotriene-B(4) 20-monooxygenase 2
    leukotriene-B(4) omega-1/omega-2 hydroxylase
    leukotriene-B(4) omega-hydroxylase 2
    NP_077764.2
    XP_006509811.1
    XP_006509812.1
    XP_011240629.1
    XP_030099642.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024444.2 → NP_077764.2  cytochrome P450 4F3

      See identical proteins and their annotated locations for NP_077764.2

      Status: VALIDATED

      Source sequence(s)
      AC162522, AK007863, BB804325
      Consensus CDS
      CCDS22406.1
      UniProtKB/Swiss-Prot
      E9QLZ3, Q99N16, Q9D8N4
      Related
      ENSMUSP00000003574.5, ENSMUST00000003574.5
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 516
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      72742326..72763512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242327.3 → XP_011240629.1  cytochrome P450 4F3 isoform X2

      Conserved Domains (1) summary
      pfam00067
      Location:52 → 381
      p450; Cytochrome P450

    2. XM_006509748.3 → XP_006509811.1  cytochrome P450 4F3 isoform X1

      See identical proteins and their annotated locations for XP_006509811.1

      UniProtKB/Swiss-Prot
      E9QLZ3, Q99N16, Q9D8N4
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 516
      p450; Cytochrome P450

    3. XM_006509749.5 → XP_006509812.1  cytochrome P450 4F3 isoform X3

      Conserved Domains (1) summary
      pfam00067
      Location:1 → 379
      p450; Cytochrome P450

    4. XM_030243782.1 → XP_030099642.1  cytochrome P450 4F3 isoform X3

      Conserved Domains (1) summary
      pfam00067
      Location:1 → 379
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99N16.2 GenPept UniProtKB/Swiss-Prot:Q99N16

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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