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    Rgs20 regulator of G-protein signaling 20 [ Mus musculus (house mouse) ]

    Gene ID: 58175, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rgs20provided by MGI
    Official Full Name
    regulator of G-protein signaling 20provided by MGI
    Primary source
    MGI:MGI:1929866
    See related
    Ensembl:ENSMUSG00000002459 AllianceGenome:MGI:1929866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rgsz1; 2900073E09Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in trans-Golgi network. Is expressed in ventricular layer. Orthologous to human RGS20 (regulator of G protein signaling 20). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 4.4), frontal lobe adult (RPKM 4.0) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 A1; 1 1.8 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (4976342..5140528, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (4909573..5070299, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00043 Neighboring gene predicted gene, 57794 Neighboring gene transcription elongation factor A (SII) 1 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00045 Neighboring gene STARR-seq mESC enhancer starr_00046 Neighboring gene STARR-seq mESC enhancer starr_00048 Neighboring gene STARR-seq mESC enhancer starr_00049 Neighboring gene predicted gene 16041 Neighboring gene STARR-seq mESC enhancer starr_00050 Neighboring gene STARR-seq mESC enhancer starr_00051 Neighboring gene heat shock protein 1 (chaperonin) pseudogene 17 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit H Neighboring gene STARR-seq mESC enhancer starr_00054 Neighboring gene STARR-seq mESC enhancer starr_00056 Neighboring gene STARR-seq mESC enhancer starr_00057 Neighboring gene STARR-seq mESC enhancer starr_00060 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Regional and Projection-Specific Role of RGSz1 in the Ventrolateral Periaqueductal Grey in the Modulation of Morphine Reward. Sakloth F, et al. Mol Pharmacol, 2023 Jan. PMID 36310031, Free PMC Article
    2. Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway. Gaspari S, et al. Proc Natl Acad Sci U S A, 2018 Feb 27. PMID 29440403, Free PMC Article
    3. RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20. Barker SA, et al. Genomics, 2001 Dec. PMID 11735229
    4. The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. Nixon AB, et al. J Biol Chem, 2002 May 17. PMID 11882662
    5. A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Nagata Y, et al. Blood, 2001 May 15. PMID 11342430

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Regional and Projection-Specific Role of RGSz1 in the Ventrolateral Periaqueductal Grey in the Modulation of Morphine Reward.
      Title: A Regional and Projection-Specific Role of RGSz1 in the Ventrolateral Periaqueductal Grey in the Modulation of Morphine Reward.
    2. RGSz1 function suppression optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/beta-catenin pathway
      Title: Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway.
    3. Analysis of in vitro microtubule polymerization/depolymerization showed that binding of RGSZ1 to SCG10 effectively blocked the ability of SCG10 to induce microtubule disassembly
      Title: The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC151302, MGC151306

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 20
    Names
    regulator of G-protein signaling Z1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177795.1 → NP_001171266.1  regulator of G-protein signaling 20 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC102311, AK078208, BI730177, BI735670
      Consensus CDS
      CCDS48213.1
      UniProtKB/TrEMBL
      E9Q720
      Related
      ENSMUSP00000113398.2, ENSMUST00000118000.8
      Conserved Domains (1) summary
      cl02565
      Location:205 → 360
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. NM_001290372.1 → NP_001277301.1  regulator of G-protein signaling 20 isoform 3

      See identical proteins and their annotated locations for NP_001277301.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC102242, AC102311, AK158864
      Consensus CDS
      CCDS69859.1
      UniProtKB/TrEMBL
      Q8C5J7
      Related
      ENSMUSP00000113324.2, ENSMUST00000119256.8
      Conserved Domains (1) summary
      cl02565
      Location:41 → 196
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    3. NM_021374.5 → NP_067349.2  regulator of G-protein signaling 20 isoform 2

      See identical proteins and their annotated locations for NP_067349.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (2) is shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC102311, AK158864, BC116925, BY127242
      Consensus CDS
      CCDS14807.1
      UniProtKB/Swiss-Prot
      Q14A97, Q3TY63, Q9CUV8, Q9QZB1, Q9QZB2
      Related
      ENSMUSP00000002533.9, ENSMUST00000002533.15
      Conserved Domains (1) summary
      cl02565
      Location:72 → 227
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      4976342..5140528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152522.1 → XP_036008415.1  regulator of G-protein signaling 20 isoform X2

      UniProtKB/TrEMBL
      Q8C5J7
      Conserved Domains (1) summary
      cl02565
      Location:41 → 196
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. XM_036152516.1 → XP_036008409.1  regulator of G-protein signaling 20 isoform X1

      UniProtKB/Swiss-Prot
      Q14A97, Q3TY63, Q9CUV8, Q9QZB1, Q9QZB2
      Conserved Domains (1) summary
      cl02565
      Location:72 → 227
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    3. XM_011238400.2 → XP_011236702.1  regulator of G-protein signaling 20 isoform X2

      See identical proteins and their annotated locations for XP_011236702.1

      UniProtKB/TrEMBL
      Q8C5J7
      Conserved Domains (1) summary
      cl02565
      Location:41 → 196
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    4. XM_006495554.3 → XP_006495617.1  regulator of G-protein signaling 20 isoform X4

      Conserved Domains (1) summary
      cl02565
      Location:17 → 139
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    5. XM_036152539.1 → XP_036008432.1  regulator of G-protein signaling 20 isoform X5

      Conserved Domains (1) summary
      cl02565
      Location:1 → 110
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    6. XM_036152535.1 → XP_036008428.1  regulator of G-protein signaling 20 isoform X4

      Conserved Domains (1) summary
      cl02565
      Location:17 → 139
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    7. XM_011238401.4 → XP_011236703.1  regulator of G-protein signaling 20 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZB1.1 GenPept UniProtKB/Swiss-Prot:Q9QZB1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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