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    Polr3d polymerase (RNA) III (DNA directed) polypeptide D [ Mus musculus (house mouse) ]

    Gene ID: 67065, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Polr3dprovided by MGI
    Official Full Name
    polymerase (RNA) III (DNA directed) polypeptide Dprovided by MGI
    Primary source
    MGI:MGI:1914315
    See related
    Ensembl:ENSMUSG00000000776 AllianceGenome:MGI:1914315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPC4; 44kDa; BN51T; TSBN51; 2810426M17Rik
    Summary
    Enables chromatin binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to act upstream of or within defense response to virus and innate immune response. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including 1st branchial arch; limb; nervous system; respiratory system; and sensory organ. Orthologous to human POLR3D (RNA polymerase III subunit D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 15.9), CNS E11.5 (RPKM 14.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 D2; 14 36.32 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70676188..70680911, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70438748..70443471, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene piwi-like RNA-mediated gene silencing 2 Neighboring gene predicted gene, 22725 Neighboring gene predicted gene, 24890 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70842927-70843227 Neighboring gene microRNA 320 Neighboring gene phytanoyl-CoA hydroxylase interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A multiplicity of factors contributes to selective RNA polymerase III occupancy of a subset of RNA polymerase III genes in mouse liver. Canella D, et al. Genome Res, 2012 Apr. PMID 22287103, Free PMC Article
    2. Gene duplication and neofunctionalization: POLR3G and POLR3GL. Renaud M, et al. Genome Res, 2014 Jan. PMID 24107381, Free PMC Article
    3. PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts. Cairo S, et al. Oncogene, 2005 Mar 24. PMID 15735755
    4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC4
    Names
    BN51 (BHK21) temperature sensitivity complementing
    DNA-directed RNA polymerase III subunit C4
    DNA-directed RNA polymerase III subunit D
    RNA polymerase III subunit C4
    NP_001157554.1
    NP_080221.3
    XP_006519501.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164082.1 → NP_001157554.1  DNA-directed RNA polymerase III subunit RPC4

      See identical proteins and their annotated locations for NP_001157554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122268, AI326828, AK013165, AW491400, CA548436
      Consensus CDS
      CCDS27253.1
      UniProtKB/Swiss-Prot
      Q3U0T3, Q91WD1, Q9CZ02
      Related
      ENSMUSP00000137614.2, ENSMUST00000180358.3
      Conserved Domains (1) summary
      pfam05132
      Location:321 → 387
      RNA_pol_Rpc4; RNA polymerase III RPC4

    2. NM_025945.3 → NP_080221.3  DNA-directed RNA polymerase III subunit RPC4

      See identical proteins and their annotated locations for NP_080221.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122268, AI326828, AK013165, AW491400, CD553533
      Consensus CDS
      CCDS27253.1
      UniProtKB/Swiss-Prot
      Q3U0T3, Q91WD1, Q9CZ02
      Related
      ENSMUSP00000000793.6, ENSMUST00000000793.13
      Conserved Domains (1) summary
      pfam05132
      Location:321 → 387
      RNA_pol_Rpc4; RNA polymerase III RPC4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      70676188..70680911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519438.1 → XP_006519501.1  DNA-directed RNA polymerase III subunit RPC4 isoform X1

      Conserved Domains (1) summary
      pfam05132
      Location:135 → 261
      RNA_pol_Rpc4; RNA polymerase III RPC4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WD1.2 GenPept UniProtKB/Swiss-Prot:Q91WD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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