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    Tssk3 testis-specific serine kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 58864, updated on 18-Apr-2024

    Summary

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    Official Symbol
    Tssk3provided by MGI
    Official Full Name
    testis-specific serine kinase 3provided by MGI
    Primary source
    MGI:MGI:1929914
    See related
    Ensembl:ENSMUSG00000000411 AllianceGenome:MGI:1929914
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tsk-3; Stk22c; Stk22d; Tssk-3; Tssk3b; 1700014N07Rik; 4930594I21Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within spermatogenesis. Is expressed in germ cell of testis; spermatid; spermatocyte; and testis. Orthologous to human TSSK3 (testis specific serine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 112.4) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.2; 4 63.26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129382801..129385523, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129489008..129491730, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129138525-129138708 Neighboring gene predicted gene, 24621 Neighboring gene BSD domain containing 1 Neighboring gene family with sequence similarity 229, member A Neighboring gene STARR-positive B cell enhancer ABC_E6223 Neighboring gene STARR-seq mESC enhancer starr_11499 Neighboring gene MARCKS-like 1 Neighboring gene histone deacetylase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1039

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility. Nozawa K, et al. Andrology, 2023 Jul. PMID 36306217,
    2. TSSK3, a novel target for male contraception, is required for spermiogenesis. Nayyab S, et al. Mol Reprod Dev, 2021 Nov. PMID 34623009, Free PMC Article
    3. Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling. Bucko-Justyna M, et al. FEBS J, 2005 Dec. PMID 16336268
    4. Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases. Visconti PE, et al. Genomics, 2001 Oct. PMID 11597141
    5. A novel member of the testis specific serine kinase family, tssk-3, expressed in the Leydig cells of sexually mature mice. Zuercher G, et al. Mech Dev, 2000 May. PMID 10781952

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility.
      Title: Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility.
    2. PDK1-induced phosphorylation increased in vitro TSSK3 kinase activity, suggesting that TSSK3 can be regulated in the same way as AGC kinase family members. The peptide sequence RRSSSY containing Ser5 is identified as a target for TSSK3 phosphorylation
      Title: Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm capacitation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    testis-specific serine/threonine-protein kinase 3
    Names
    serine/threonine kinase 22C (spermiogenesis associated)
    serine/threonine-protein kinase 22C
    spermiogenesis associated serine/threonine kinase 22D
    testis-specific kinase 3
    testis-specific serine/threonine kinase 3b
    NP_536690.1
    XP_006503317.1
    XP_030109549.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080442.2 → NP_536690.1  testis-specific serine/threonine-protein kinase 3

      See identical proteins and their annotated locations for NP_536690.1

      Status: VALIDATED

      Source sequence(s)
      AK019840
      Consensus CDS
      CCDS18693.1
      UniProtKB/Swiss-Prot
      Q9D2E1, Q9JL98
      Related
      ENSMUSP00000000421.6, ENSMUST00000000421.6
      Conserved Domains (1) summary
      cd14163
      Location:9 → 265
      STKc_TSSK3-like; Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129382801..129385523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253689.1 → XP_030109549.1  testis-specific serine/threonine-protein kinase 3 isoform X1

      UniProtKB/Swiss-Prot
      Q9D2E1, Q9JL98
      Conserved Domains (1) summary
      cd14163
      Location:9 → 265
      STKc_TSSK3-like; Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins

    2. XM_006503254.4 → XP_006503317.1  testis-specific serine/threonine-protein kinase 3 isoform X2

      See identical proteins and their annotated locations for XP_006503317.1

      Conserved Domains (1) summary
      cl21453
      Location:1 → 190
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2E1.1 GenPept UniProtKB/Swiss-Prot:Q9D2E1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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