Cav2 caveolin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cav2provided by MGI
Official Full Name: caveolin 2provided by MGI
Primary source: MGI:MGI:107571
See related: Ensembl:ENSMUSG00000000058 AllianceGenome:MGI:107571
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. This gene is located adjacent to caveolin-1 and the proteins coexpressed by the two genes localize together in caveolae, where they form hetero-oligomers. The encoded protein may be involved in diverse cellular functions including proliferation, differentiation, endocytosis and trafficking. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 86.2), genital fat pad adult (RPKM 79.9) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 7.72 cM; 6 A2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (17281184..17289129)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (17281185..17289130)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased Caveolin-2 Expression in Brain Endothelial Cells Promotes Age-Related Neuroinflammation.
Title: Increased Caveolin-2 Expression in Brain Endothelial Cells Promotes Age-Related Neuroinflammation.
Elevated postischemic tissue injury and leukocyte-endothelial adhesive interactions in mice with global deficiency in caveolin-2: role of PAI-1.
Title: Elevated postischemic tissue injury and leukocyte-endothelial adhesive interactions in mice with global deficiency in caveolin-2: role of PAI-1.
Caveolin-2 deficiency induces a rapid anti-tumor immune response prior to regression of implanted murine lung carcinoma tumors.
Title: Caveolin-2 deficiency induces a rapid anti-tumor immune response prior to regression of implanted murine lung carcinoma tumors.
While structural and functional properties of resistance networks are well maintained in the gluteus muscle of Cav2(-/-) mice, diminished rapid onset vasodilation with greater force production reveals novel physiological roles for Cav2 in skeletal muscle.
Title: Attenuated rapid onset vasodilation with greater force production in skeletal muscle of caveolin-2-/- mice.
We concluded that caveolin-2 is most probably involved in regulation of pro-inflammatory responses of BMDMs, triggered via activation of ERK1/2.
Title: Bone marrow-derived macrophages exclusively expressed caveolin-2: The role of inflammatory activators and hypoxia.
Cav-2 expressed in tumor microenvironment may potentially become a novel target for cancer therapy
Title: Host deficiency in caveolin-2 inhibits lung carcinoma tumor growth by impairing tumor angiogenesis.
In contrast to wild-type-Cav-2, retroviral re-expression of Y19/27F-Cav-2 in Cav-2 knockout endothelial cells did not affect anti-proliferative effect of TGF-beta compared to empty vector.
Title: N-terminal tyrosine phosphorylation of caveolin-2 negates anti-proliferative effect of transforming growth factor beta in endothelial cells.
Data show that the balance between caveolin-1 and caveolin-2 is important for iNOS expression and ultimately for sepsis outcome.
Title: Caveolin-2-deficient mice show increased sensitivity to endotoxemia.
The negative regulation of transforming growth factor-beta1 signaling and function by caveolin 2 is independent of caveolin 1 expression levels and is not because of changing targeting of caveolin 1 protein to plasma membrane lipid raft/caveolar domains.
Title: Caveolin-2 is a negative regulator of anti-proliferative function and signaling of transforming growth factor-β in endothelial cells.
Data suggest that Cav-2 negatively regulates lung endothelial cell proliferation and cell cycle progression.
Title: Endothelial cells isolated from caveolin-2 knockout mice display higher proliferation rate and cell cycle progression relative to their wild-type counterparts.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

PMC133690P1 (e-PCR)
- UniSTS:270637

PMC133690P2 (e-PCR)
- UniSTS:270638

AI447843 (e-PCR)
- UniSTS:179338

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D1 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables D1 dopamine receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in caveola assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in caveola assembly	ISO Inferred from Sequence Orthology more info
involved_in caveola assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocytosis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within endoplasmic reticulum organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of endothelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of skeletal muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dopamine receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis of virus by host cell	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of skeletal muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vesicle docking	ISO Inferred from Sequence Orthology more info
involved_in vesicle docking	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in vesicle fusion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in vesicle organization	ISO Inferred from Sequence Orthology more info
involved_in viral release from host cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	ISO Inferred from Sequence Orthology more info	PubMed
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of caveolar macromolecular signaling complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info	PubMed
colocalizes_with focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with focal adhesion	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with focal adhesion	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear inner membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
colocalizes_with sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caveolin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277756.1 → NP_001264685.1 caveolin-2 isoform 2

See identical proteins and their annotated locations for NP_001264685.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) transcribes past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter at the C-terminus, compared to isoform 1.

Source sequence(s)

AA475015, AC023173

Consensus CDS

CCDS71727.1

UniProtKB/TrEMBL

Q924U3, Q924U4

Related

ENSMUSP00000111119.2, ENSMUST00000115459.2

Conserved Domains (1) summary

pfam01146
Location:39 → 113

Caveolin; Caveolin
NM_016900.4 → NP_058596.1 caveolin-2 isoform 1

See identical proteins and their annotated locations for NP_058596.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC023173, AK009913, AK151397, AK158419, CJ157462

Consensus CDS

CCDS19923.1

UniProtKB/Swiss-Prot

Q3TYR4, Q9WVC3

Related

ENSMUSP00000000058.7, ENSMUST00000000058.7

Conserved Domains (1) summary

pfam01146
Location:39 → 160

Caveolin; Caveolin