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    Cdc45 cell division cycle 45 [ Mus musculus (house mouse) ]

    Gene ID: 12544, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Cdc45provided by MGI
    Official Full Name
    cell division cycle 45provided by MGI
    Primary source
    MGI:MGI:1338073
    See related
    Ensembl:ENSMUSG00000000028 AllianceGenome:MGI:1338073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdc45l
    Summary
    Predicted to enable DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation; double-strand break repair via break-induced replication; and mitotic DNA replication preinitiation complex assembly. Predicted to act upstream of or within DNA replication. Predicted to be located in centrosome; ciliary basal body; and nucleoplasm. Predicted to be part of DNA replication preinitiation complex. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and notochord. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14.5 (RPKM 24.8), liver E14 (RPKM 24.1) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 A3; 16 11.63 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18599202..18632371, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18780447..18811972, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41428 Neighboring gene claudin 5 Neighboring gene STARR-positive B cell enhancer ABC_E763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:18812268-18812501 Neighboring gene predicted gene, 52240 Neighboring gene RIKEN cDNA 2510002D24 gene Neighboring gene STARR-positive B cell enhancer ABC_E10892 Neighboring gene ubiquitin recognition factor in ER-associated degradation 1 Neighboring gene mitochondrial ribosomal protein L40 Neighboring gene histone cell cycle regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cdc45 is a critical effector of myc-dependent DNA replication stress. Srinivasan SV, et al. Cell Rep, 2013 May 30. PMID 23643534, Free PMC Article
    2. A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45L. Kunte A, et al. Mech Dev, 2001 Oct. PMID 11578863
    3. Requirement of CDC45 for postimplantation mouse development. Yoshida K, et al. Mol Cell Biol, 2001 Jul. PMID 11416137, Free PMC Article
    4. Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development. Shaikh TH, et al. Mamm Genome, 1999 Mar. PMID 10051334
    5. Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. McKie JM, et al. Genome Res, 1998 Aug. PMID 9724329, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DONSON is required for CMG helicase assembly in the mammalian cell cycle.
      Title: DONSON is required for CMG helicase assembly in the mammalian cell cycle.
    2. Cdc45 Recapitulates Myc-Dependent DNA Replication Stress.
      Title: Cdc45 is a critical effector of myc-dependent DNA replication stress.
    3. MCM4 phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 on chromatin
      Title: Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA unwinding involved in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CMG complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of DNA replication preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division control protein 45 homolog
    Names
    CDC45-related protein
    PORC-PI-1
    cell division cycle 45 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161623.3 → NP_001155095.1  cell division control protein 45 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC083895
      Consensus CDS
      CCDS49788.1
      UniProtKB/TrEMBL
      F8WJ72, Q3TIH7
      Related
      ENSMUSP00000094753.4, ENSMUST00000096990.10
      Conserved Domains (1) summary
      pfam02724
      Location:19 → 515
      CDC45; CDC45-like protein

    2. NM_001358206.2 → NP_001345135.1  cell division control protein 45 homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same protein.
      Source sequence(s)
      AC083895
      Consensus CDS
      CCDS28027.1
      UniProtKB/Swiss-Prot
      O70547, Q9QUK1, Q9R212, Q9Z1X9
      UniProtKB/TrEMBL
      Q3TIH7, Q3UI99
      Conserved Domains (1) summary
      pfam02724
      Location:19 → 561
      CDC45; CDC45-like protein

    3. NM_001416648.1 → NP_001403577.1  cell division control protein 45 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC083895

    4. NM_001416649.1 → NP_001403578.1  cell division control protein 45 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC083895

    5. NM_001416651.1 → NP_001403580.1  cell division control protein 45 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC083895

    6. NM_001416660.1 → NP_001403589.1  cell division control protein 45 homolog isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC083895

    7. NM_001416663.1 → NP_001403592.1  cell division control protein 45 homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC083895

    8. NM_009862.3 → NP_033992.2  cell division control protein 45 homolog isoform 1

      See identical proteins and their annotated locations for NP_033992.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same protein.
      Source sequence(s)
      AC083895
      Consensus CDS
      CCDS28027.1
      UniProtKB/Swiss-Prot
      O70547, Q9QUK1, Q9R212, Q9Z1X9
      UniProtKB/TrEMBL
      Q3TIH7, Q3UI99
      Related
      ENSMUSP00000000028.8, ENSMUST00000000028.14
      Conserved Domains (1) summary
      pfam02724
      Location:19 → 561
      CDC45; CDC45-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      18599202..18632371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159760.1 → XP_036015653.1  cell division control protein 45 homolog isoform X1

      UniProtKB/Swiss-Prot
      O70547, Q9QUK1, Q9R212, Q9Z1X9
      UniProtKB/TrEMBL
      Q3TIH7, Q3UI99
      Conserved Domains (1) summary
      pfam02724
      Location:19 → 561
      CDC45; CDC45-like protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1X9.2 GenPept UniProtKB/Swiss-Prot:Q9Z1X9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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