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    Rab13 RAB13, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 68328, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rab13provided by MGI
    Official Full Name
    RAB13, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:1927232
    See related
    Ensembl:ENSMUSG00000027935 AllianceGenome:MGI:1927232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610007N03Rik; B230212B15Rik
    Summary
    Predicted to enable GTP binding activity and protein kinase A catalytic subunit binding activity. Involved in endocytic recycling; endothelial cell chemotaxis; and protein localization to cell leading edge. Located in several cellular components, including bicellular tight junction; endocytic vesicle; and lamellipodium. Is expressed in brain; early conceptus; lung; meninges; and secondary oocyte. Orthologous to human RAB13 (RAB13, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.2), limb E14.5 (RPKM 5.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F1; 3 39.21 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90121022..90133694)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90213715..90226387)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene nucleoporin 210-like Neighboring gene predicted gene, 24185 Neighboring gene STARR-positive B cell enhancer ABC_E1624 Neighboring gene ribosomal protein S27 Neighboring gene cAMP responsive element binding protein 3-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E1265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90052523-90052632 Neighboring gene jumping translocation breakpoint Neighboring gene solute carrier family 39 (zinc transporter), member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exosomal proteomics identifies RAB13 as a potential regulator of metastasis for HCC. Huang XY, et al. Hepatol Commun, 2023 Jan 1. PMID 36633475, Free PMC Article
    2. Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking. Nishikimi A, et al. Sci Signal, 2014 Jul 29. PMID 25074980
    3. Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis. Sato T, et al. J Cell Sci, 2014 Jan 15. PMID 24213529, Free PMC Article
    4. JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin. Terai T, et al. Mol Biol Cell, 2006 May. PMID 16525024, Free PMC Article
    5. Rab13 mediates the continuous endocytic recycling of occludin to the cell surface. Morimoto S, et al. J Biol Chem, 2005 Jan 21. PMID 15528189

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomal proteomics identifies RAB13 as a potential regulator of metastasis for HCC.
      Title: Exosomal proteomics identifies RAB13 as a potential regulator of metastasis for HCC.
    2. Rab13 acts with Mst1 to regulate the spatial distribution of LFA-1 and the motility and trafficking of lymphocytes
      Title: Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.
    3. Rab13 associates with Grb2, targeting Syx and RhoA to Tyr(1175)-phosphorylated VEGFR2 at the leading edge.
      Title: Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis.
    4. Rab13 and Rab8A are Rab-GTPases activated by insulin and downstream of AS160 they regulate traffic of GLUT4 vesicles.
      Title: Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of Sertoli cell barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein kinase A signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cell leading edge IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extrinsic component of plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in insulin-responsive compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293741.1 → NP_001280670.1  ras-related protein Rab-13 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the use of an alternate promoter, has a different 5' structure, and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC119825, AI529508, AK080805
      Consensus CDS
      CCDS79962.1
      UniProtKB/TrEMBL
      D3YUS4
      Related
      ENSMUSP00000102996.2, ENSMUST00000107373.8
      Conserved Domains (1) summary
      cl21455
      Location:1 → 91
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_026677.4 → NP_080953.1  ras-related protein Rab-13 isoform 1

      See identical proteins and their annotated locations for NP_080953.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC119825, AI529508, AK002303, AK080805, BB867138
      Consensus CDS
      CCDS17522.1
      UniProtKB/Swiss-Prot
      Q9DD03
      UniProtKB/TrEMBL
      Q0PD42
      Related
      ENSMUSP00000070588.7, ENSMUST00000065418.7
      Conserved Domains (2) summary
      smart00175
      Location:9 → 170
      RAB; Rab subfamily of small GTPases
      cd01867
      Location:6 → 172
      Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      90121022..90133694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DD03.1 GenPept UniProtKB/Swiss-Prot:Q9DD03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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