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    Mfsd10 major facilitator superfamily domain containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 68294, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mfsd10provided by MGI
    Official Full Name
    major facilitator superfamily domain containing 10provided by MGI
    Primary source
    MGI:MGI:1915544
    See related
    Ensembl:ENSMUSG00000001082 AllianceGenome:MGI:1915544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tetran; 0610009O03Rik
    Summary
    Predicted to enable organic anion transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within sodium-independent organic anion transport. Located in brush border membrane and nuclear inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human MFSD10 (major facilitator superfamily domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 78.2), limb E14.5 (RPKM 51.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 B2; 5 17.9 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34790988..34794558, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34633644..34637215, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene SH3-domain binding protein 2 Neighboring gene predicted gene, 22847 Neighboring gene STARR-positive B cell enhancer ABC_E3568 Neighboring gene microRNA 7036b Neighboring gene STARR-seq mESC enhancer starr_12845 Neighboring gene adducin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34979450-34979637 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:35002815-35002998 Neighboring gene NOP14 nucleolar protein Neighboring gene predicted gene 15522 Neighboring gene G protein-coupled receptor kinase 4 Neighboring gene microRNA 467g

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption. Bagchi S, et al. Int J Neurosci, 2020 May. PMID 31906755
    2. Expression and function of TETRAN, a new type of membrane transporter. Ushijima H, et al. Biochem Biophys Res Commun, 2008 Sep 19. PMID 18638446
    3. Identification of new transmembrane proteins concentrated at the nuclear envelope using organellar proteomics of mesenchymal cells. Cheng LC, et al. Nucleus, 2019 Dec. PMID 31142202, Free PMC Article
    4. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption.
      Title: Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sodium-independent organic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in brush border membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    major facilitator superfamily domain-containing protein 10
    Names
    tetracycline transporter-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356978.2 → NP_001343907.1  major facilitator superfamily domain-containing protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115695
      Consensus CDS
      CCDS19217.1
      UniProtKB/Swiss-Prot
      Q3U800, Q3UN73, Q9D1A7, Q9D2V8
      Related
      ENSMUSP00000109968.2, ENSMUST00000114329.8
      Conserved Domains (1) summary
      cl28910
      Location:52 → 434
      MFS; Major Facilitator Superfamily

    2. NM_001356979.2 → NP_001343908.1  major facilitator superfamily domain-containing protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115695
      Consensus CDS
      CCDS19217.1
      UniProtKB/Swiss-Prot
      Q3U800, Q3UN73, Q9D1A7, Q9D2V8
      Related
      ENSMUSP00000109970.4, ENSMUST00000114331.10
      Conserved Domains (1) summary
      cl28910
      Location:52 → 434
      MFS; Major Facilitator Superfamily

    3. NM_001412500.1 → NP_001399429.1  major facilitator superfamily domain-containing protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115695
      UniProtKB/Swiss-Prot
      Q3U800, Q3UN73, Q9D1A7, Q9D2V8

    4. NM_001412501.1 → NP_001399430.1  major facilitator superfamily domain-containing protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115695
      UniProtKB/Swiss-Prot
      Q3U800, Q3UN73, Q9D1A7, Q9D2V8

    5. NM_001412502.1 → NP_001399431.1  major facilitator superfamily domain-containing protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115695
      UniProtKB/Swiss-Prot
      Q3U800, Q3UN73, Q9D1A7, Q9D2V8

    6. NM_001412503.1 → NP_001399432.1  major facilitator superfamily domain-containing protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115695
      UniProtKB/Swiss-Prot
      Q3U800, Q3UN73, Q9D1A7, Q9D2V8

    7. NM_001412504.1 → NP_001399433.1  major facilitator superfamily domain-containing protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115695
      UniProtKB/Swiss-Prot
      Q3U800, Q3UN73, Q9D1A7, Q9D2V8

    8. NM_001412505.1 → NP_001399434.1  major facilitator superfamily domain-containing protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115695
      UniProtKB/Swiss-Prot
      Q3U800, Q3UN73, Q9D1A7, Q9D2V8

    9. NM_001412506.1 → NP_001399435.1  major facilitator superfamily domain-containing protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115695

    10. NM_001412507.1 → NP_001399436.1  major facilitator superfamily domain-containing protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115695

    11. NM_001412508.1 → NP_001399437.1  major facilitator superfamily domain-containing protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115695

    12. NM_001412509.1 → NP_001399438.1  major facilitator superfamily domain-containing protein 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC115695

    13. NM_001412510.1 → NP_001399439.1  major facilitator superfamily domain-containing protein 10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC115695

    14. NM_001412511.1 → NP_001399440.1  major facilitator superfamily domain-containing protein 10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC115695

    15. NM_026660.4 → NP_080936.1  major facilitator superfamily domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_080936.1

      Status: VALIDATED

      Source sequence(s)
      AC115695
      Consensus CDS
      CCDS19217.1
      UniProtKB/Swiss-Prot
      Q3U800, Q3UN73, Q9D1A7, Q9D2V8
      Related
      ENSMUSP00000001109.5, ENSMUST00000001109.11
      Conserved Domains (1) summary
      cl28910
      Location:52 → 434
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      34790988..34794558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254781.2 → XP_030110641.1  major facilitator superfamily domain-containing protein 10 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:1 → 257
      MFS; Major Facilitator Superfamily

    2. XM_006504079.5 → XP_006504142.1  major facilitator superfamily domain-containing protein 10 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:1 → 241
      MFS; Major Facilitator Superfamily

    3. XM_011240768.4 → XP_011239070.1  major facilitator superfamily domain-containing protein 10 isoform X2

      See identical proteins and their annotated locations for XP_011239070.1

      UniProtKB/Swiss-Prot
      Q9D2V8
      Conserved Domains (1) summary
      cl28910
      Location:1 → 257
      MFS; Major Facilitator Superfamily

    RNA

    1. XR_004942554.1 RNA Sequence

    2. XR_868298.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2V8.1 GenPept UniProtKB/Swiss-Prot:Q9D2V8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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