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    Slc25a22 solute carrier family 25 (mitochondrial carrier, glutamate), member 22 [ Mus musculus (house mouse) ]

    Gene ID: 68267, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Slc25a22provided by MGI
    Official Full Name
    solute carrier family 25 (mitochondrial carrier, glutamate), member 22provided by MGI
    Primary source
    MGI:MGI:1915517
    See related
    Ensembl:ENSMUSG00000019082 AllianceGenome:MGI:1915517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gc1; 1300006L01Rik
    Summary
    Predicted to enable L-aspartate transmembrane transporter activity and L-glutamate transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport; aspartate transmembrane transport; and malate-aspartate shuttle. Located in mitochondrion. Is expressed in alimentary system; eye; liver; and nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 3. Orthologous to human SLC25A22 (solute carrier family 25 member 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 89.8), duodenum adult (RPKM 85.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F5; 7 86.78 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141009662..141017787, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141429749..141437874, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glutamine amidotransferase like class 1 domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3761 Neighboring gene cell cycle exit and neuronal differentiation 1 Neighboring gene STARR-positive B cell enhancer ABC_E4986 Neighboring gene p53 induced death domain protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1097 Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene small nucleolar RNA, H/ACA box 52

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance. Wong CC, et al. Gastroenterology, 2020 Dec. PMID 32814111
    2. Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion. Casimir M, et al. J Biol Chem, 2009 Sep 11. PMID 19584051, Free PMC Article
    3. Transposon vectors for gene-trap insertional mutagenesis in vertebrates. Clark KJ, et al. Genesis, 2004 Aug. PMID 15286994
    4. Transposon mutagenesis of the mouse germline. Carlson CM, et al. Genetics, 2003 Sep. PMID 14504232, Free PMC Article
    5. The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters. Aleidi SM, et al. J Biol Chem, 2015 Oct 2. PMID 26296893, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.
      Title: In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-aspartate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amino acid:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-glutamate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aspartate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in malate-aspartate shuttle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    mitochondrial glutamate carrier 1
    Names
    glutamate/H(+) symporter 1
    solute carrier family 25 member 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177576.1 → NP_001171047.1  mitochondrial glutamate carrier 1 isoform a

      See identical proteins and their annotated locations for NP_001171047.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AK010193, AK162400, BC050887, BY296753
      Consensus CDS
      CCDS22013.1
      UniProtKB/Swiss-Prot
      Q3TRY1, Q9D6M3
      Related
      ENSMUSP00000101629.4, ENSMUST00000106007.10
      Conserved Domains (2) summary
      PTZ00169
      Location:3 → 289
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:6 → 96
      Mito_carr; Mitochondrial carrier protein

    2. NM_001360723.1 → NP_001347652.1  mitochondrial glutamate carrier 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC158224
      Consensus CDS
      CCDS22013.1
      UniProtKB/Swiss-Prot
      Q3TRY1, Q9D6M3
      Conserved Domains (2) summary
      PTZ00169
      Location:3 → 289
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:6 → 96
      Mito_carr; Mitochondrial carrier protein

    3. NM_001360724.1 → NP_001347653.1  mitochondrial glutamate carrier 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC158224
      Related
      ENSMUST00000140602.8
      Conserved Domains (1) summary
      pfam00153
      Location:19 → 128
      Mito_carr; Mitochondrial carrier protein

    4. NM_026646.3 → NP_080922.1  mitochondrial glutamate carrier 1 isoform a

      See identical proteins and their annotated locations for NP_080922.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC158224, AK010193, BC050887
      Consensus CDS
      CCDS22013.1
      UniProtKB/Swiss-Prot
      Q3TRY1, Q9D6M3
      Related
      ENSMUSP00000019226.8, ENSMUST00000019226.14
      Conserved Domains (2) summary
      PTZ00169
      Location:3 → 289
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:6 → 96
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141009662..141017787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242948.1 → XP_030098808.1  mitochondrial glutamate carrier 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3TRY1, Q9D6M3
      Conserved Domains (2) summary
      PTZ00169
      Location:3 → 289
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:6 → 96
      Mito_carr; Mitochondrial carrier protein

    2. XM_030242950.1 → XP_030098810.1  mitochondrial glutamate carrier 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3TRY1, Q9D6M3
      Conserved Domains (2) summary
      PTZ00169
      Location:3 → 289
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:6 → 96
      Mito_carr; Mitochondrial carrier protein

    3. XM_030242949.2 → XP_030098809.1  mitochondrial glutamate carrier 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3TRY1, Q9D6M3
      Conserved Domains (2) summary
      PTZ00169
      Location:3 → 289
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:6 → 96
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D6M3.1 GenPept UniProtKB/Swiss-Prot:Q9D6M3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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