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    Sympk symplekin [ Mus musculus (house mouse) ]

    Gene ID: 68188, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Sympkprovided by MGI
    Official Full Name
    symplekinprovided by MGI
    Primary source
    MGI:MGI:1915438
    See related
    Ensembl:ENSMUSG00000023118 AllianceGenome:MGI:1915438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPK; SYM; 1500016F02Rik; 4632415H16Rik
    Summary
    Predicted to be involved in mRNA polyadenylation; negative regulation of protein binding activity; and positive regulation of protein dephosphorylation. Predicted to act upstream of or within cell adhesion and mRNA processing. Located in nuclear body. Is expressed in pancreas tip epithelium. Orthologous to human SYMPK (symplekin scaffold protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 36.3), ovary adult (RPKM 34.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A3; 7 9.46 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18758321..18788542)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19024377..19054623)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 2 binding protein 1 Neighboring gene forkhead box A3 Neighboring gene radial spoke head 6 homolog A (Chlamydomonas) Neighboring gene STARR-positive B cell enhancer ABC_E8152 Neighboring gene dystrophia myotonica-containing WD repeat motif

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SYMPK Is Required for Meiosis and Involved in Alternative Splicing in Male Germ Cells. Wu R, et al. Front Cell Dev Biol, 2021. PMID 34434935, Free PMC Article
    2. Interaction Between Sympk and Oct4 Promotes Mouse Embryonic Stem Cell Proliferation. Yu J, et al. Stem Cells, 2019 Jun. PMID 30801858
    3. Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation. Liu H, et al. Dev Cell, 2017 May 22. PMID 28535374, Free PMC Article
    4. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Udagawa T, et al. Mol Cell, 2012 Jul 27. PMID 22727665, Free PMC Article
    5. Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles. Hilditch-Maguire P, et al. Hum Mol Genet, 2000 Nov 22. PMID 11092755

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    symplekin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360713.2 → NP_001347642.1  symplekin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC170864
      UniProtKB/TrEMBL
      Q3TN10
      Conserved Domains (2) summary
      pfam11935
      Location:122 → 337
      DUF3453; Domain of unknown function (DUF3453)
      pfam12295
      Location:887 → 964
      Symplekin_C; Symplekin tight junction protein C terminal

    2. NM_026605.3 → NP_080881.2  symplekin isoform 1

      See identical proteins and their annotated locations for NP_080881.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC170864
      Consensus CDS
      CCDS52051.1
      UniProtKB/Swiss-Prot
      F8WJD4, Q80X82
      UniProtKB/TrEMBL
      Q3U2B5, Q3U2V0
      Related
      ENSMUSP00000023882.8, ENSMUST00000023882.14
      Conserved Domains (2) summary
      pfam11935
      Location:122 → 336
      DUF3453; Domain of unknown function (DUF3453)
      pfam12295
      Location:887 → 1068
      Symplekin_C; Symplekin tight junction protein C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      18758321..18788542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540332.4 → XP_006540395.1  symplekin isoform X1

      See identical proteins and their annotated locations for XP_006540395.1

      UniProtKB/Swiss-Prot
      F8WJD4, Q80X82
      UniProtKB/TrEMBL
      Q3U2B5, Q3U2V0
      Conserved Domains (2) summary
      pfam11935
      Location:122 → 336
      DUF3453; Domain of unknown function (DUF3453)
      pfam12295
      Location:887 → 1068
      Symplekin_C; Symplekin tight junction protein C terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80X82.2 GenPept UniProtKB/Swiss-Prot:Q80X82

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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