Entr1 endosome associated trafficking regulator 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Entr1provided by MGI
Official Full Name: endosome associated trafficking regulator 1provided by MGI
Primary source: MGI:MGI:1915362
See related: Ensembl:ENSMUSG00000026927 AllianceGenome:MGI:1915362
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sdccag3; C330016H24Rik; C630038K21Rik
Summary: Predicted to be involved in several processes, including endocytic recycling; positive regulation of cilium assembly; and positive regulation of protein localization to cilium. Predicted to act upstream of or within cell division; cell projection organization; and protein transport. Predicted to be located in endosome. Predicted to be part of retromer complex. Predicted to be active in endosome; microtubule organizing center; and midbody. Orthologous to human ENTR1 (endosome associated trafficking regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 146.9), CNS E18 (RPKM 52.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 18.88 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (26272810..26279352, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (26382798..26389340, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SDCCAG3 has a role in ciliogenesis and in localization of cargo to primary cilia
Title: The serologically defined colon cancer antigen-3 (SDCCAG3) is involved in the regulation of ciliogenesis.
These findings suggest that SDCCAG3 might function in endosomal trafficking downstream of Arf6.
Title: Interaction of serologically defined colon cancer antigen-3 with Arf6 and its predominant expression in the mouse testis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cilium	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to cilium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
part_of retromer complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endosome-associated-trafficking regulator 1

Names: serologically defined colon cancer antigen 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085407.1 → NP_001078876.1 endosome-associated-trafficking regulator 1 isoform 3

Status: VALIDATED

Source sequence(s)

AK082787, AK163690, BY104480

Consensus CDS

CCDS50541.1

UniProtKB/Swiss-Prot

A2AIW0

Related

ENSMUSP00000028293.6, ENSMUST00000028293.12

Conserved Domains (1) summary

pfam16034
Location:147 → 317

JAKMIP_CC3; JAKMIP CC3 domain
NM_001085408.1 → NP_001078877.1 endosome-associated-trafficking regulator 1 isoform 4

See identical proteins and their annotated locations for NP_001078877.1

Status: VALIDATED

Source sequence(s)

AK163690, AW743523, BY104480

Consensus CDS

CCDS50540.1

UniProtKB/Swiss-Prot

A2AIW0

Related

ENSMUSP00000077133.7, ENSMUST00000077983.13

Conserved Domains (1) summary

pfam16034
Location:124 → 294

JAKMIP_CC3; JAKMIP CC3 domain
NM_026563.3 → NP_080839.2 endosome-associated-trafficking regulator 1 isoform 1

See identical proteins and their annotated locations for NP_080839.2

Status: VALIDATED

Source sequence(s)

AK014885, AK163690, BY104480

Consensus CDS

CCDS15803.2

UniProtKB/Swiss-Prot

A2AIW0, A2AIW1, Q3TQC5, Q6P8W2, Q8BIV5, Q8K0I8, Q9D1V2, Q9D4S1, Q9D5W1

Related

ENSMUSP00000109737.4, ENSMUST00000114102.10

Conserved Domains (1) summary

pfam16034
Location:197 → 367

JAKMIP_CC3; JAKMIP CC3 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

26272810..26279352 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252001.1 → XP_030107861.1 endosome-associated-trafficking regulator 1 isoform X3

Conserved Domains (1) summary

TIGR02169
Location:186 → 285

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
XM_006498261.2 → XP_006498324.1 endosome-associated-trafficking regulator 1 isoform X1

Conserved Domains (1) summary

pfam15898
Location:269 → 357

PRKG1_interact; cGMP-dependent protein kinase interacting domain
XM_030252003.1 → XP_030107863.1 endosome-associated-trafficking regulator 1 isoform X5

Conserved Domains (1) summary

TIGR02169
Location:106 → 205

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
XM_006498262.5 → XP_006498325.1 endosome-associated-trafficking regulator 1 isoform X2

UniProtKB/TrEMBL

A2AIW3

Related

ENSMUSP00000109735.4, ENSMUST00000114100.10

Conserved Domains (1) summary

TIGR02168
Location:228 → 350

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_030252002.2 → XP_030107862.1 endosome-associated-trafficking regulator 1 isoform X4

Conserved Domains (1) summary

TIGR02168
Location:98 → 220

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_036162513.1 → XP_036018406.1 endosome-associated-trafficking regulator 1 isoform X4

Conserved Domains (1) summary

TIGR02168
Location:98 → 220

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

XR_003953706.1 RNA Sequence
XR_003953705.2 RNA Sequence
XR_003953703.2 RNA Sequence
XR_003953704.2 RNA Sequence
XR_004940714.1 RNA Sequence
XR_374113.2 RNA Sequence
XR_374114.2 RNA Sequence
XR_003953702.1 RNA Sequence
XR_004940713.1 RNA Sequence
XR_004940712.1 RNA Sequence
XR_003953701.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_030155.2: Suppressed sequence

Description

NM_030155.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript, and it contains a deletion compared to available sequence data that results in a frameshift.