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    Nt5c3b 5'-nucleotidase, cytosolic IIIB [ Mus musculus (house mouse) ]

    Gene ID: 68106, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Nt5c3bprovided by MGI
    Official Full Name
    5'-nucleotidase, cytosolic IIIBprovided by MGI
    Primary source
    MGI:MGI:1915356
    See related
    Ensembl:ENSMUSG00000017176 AllianceGenome:MGI:1915356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nt5c3l; 2610037D24Rik; C330027I04Rik
    Summary
    Predicted to enable hydrolase activity; magnesium ion binding activity; and nucleotide binding activity. Predicted to act upstream of or within nucleotide metabolic process. Predicted to be active in cytoplasm. Orthologous to human NT5C3B (5'-nucleotidase, cytosolic IIIB). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.3), limb E14.5 (RPKM 21.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 63.47 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100313143..100332634, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100422317..100441808, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12348 Neighboring gene prolyl 3-hydroxylase family member 4 (non-enzymatic) Neighboring gene FK506 binding protein 10 Neighboring gene kelch-like 10 Neighboring gene kelch-like 11 Neighboring gene STARR-positive B cell enhancer ABC_E3020 Neighboring gene microRNA 7116 Neighboring gene ATP citrate lyase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables XMP 5'-nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    7-methylguanosine phosphate-specific 5'-nucleotidase
    Names
    5'-nucleotidase, cytosolic III-like
    7-methylguanosine nucleotidase
    N(7)-methylguanylate 5'-phosphatase
    cN-III-like protein
    cytosolic 5'-nucleotidase 3B
    cytosolic 5'-nucleotidase III-like protein
    NP_001096120.1
    NP_001349895.1
    NP_001349896.1
    NP_001349897.1
    NP_080837.3
    XP_006534109.1
    XP_017170212.1
    XP_017170213.1
    XP_017170214.1
    XP_017170215.1
    XP_017170216.1
    XP_017170217.1
    XP_030102118.1
    XP_030102119.1
    XP_030102120.1
    XP_030102121.1
    XP_036012818.1
    XP_036012819.1
    XP_036012820.1
    XP_036012821.1
    XP_036012822.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102650.2 → NP_001096120.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform 1

      See identical proteins and their annotated locations for NP_001096120.1

      Status: VALIDATED

      Source sequence(s)
      AK148222, AL590968, BE944684, BY047327
      Consensus CDS
      CCDS48931.1
      UniProtKB/Swiss-Prot
      A2A4I2, A2A4I3, Q3TLP3, Q3UFY7, Q8BHU9, Q91WE8, Q9D9F9
      Related
      ENSMUSP00000090360.6, ENSMUST00000092688.12
      Conserved Domains (1) summary
      cd07504
      Location:17 → 289
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    2. NM_001362966.1 → NP_001349895.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL590968, BE944684
      Consensus CDS
      CCDS88254.1
      Related
      ENSMUSP00000103020.2, ENSMUST00000107397.2
      Conserved Domains (1) summary
      cd07504
      Location:9 → 281
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    3. NM_001362967.1 → NP_001349896.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK011707, AL590968, BE944684
      Consensus CDS
      CCDS88253.1
      UniProtKB/TrEMBL
      A0A0R4J146
      Related
      ENSMUSP00000090361.3, ENSMUST00000092689.9
      Conserved Domains (1) summary
      pfam05822
      Location:1 → 246
      UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

    4. NM_001362968.1 → NP_001349897.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AK166393, AL590968
      Related
      ENSMUST00000130666.2
      Conserved Domains (1) summary
      cl21460
      Location:17 → 76
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    5. NM_026561.5 → NP_080837.3  7-methylguanosine phosphate-specific 5'-nucleotidase isoform 2

      See identical proteins and their annotated locations for NP_080837.3

      Status: VALIDATED

      Source sequence(s)
      AK006972, AL590968
      Consensus CDS
      CCDS48930.1
      UniProtKB/Swiss-Prot
      Q3UFY7
      Related
      ENSMUSP00000103021.2, ENSMUST00000107398.8
      Conserved Domains (1) summary
      pfam05822
      Location:44 → 259
      UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100313143..100332634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156926.1 → XP_036012819.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X7

      Conserved Domains (1) summary
      cd07504
      Location:4 → 227
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    2. XM_017314725.1 → XP_017170214.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X4

      Conserved Domains (1) summary
      cd07504
      Location:25 → 268
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    3. XM_036156929.1 → XP_036012822.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X9

      Conserved Domains (1) summary
      cl21460
      Location:10 → 192
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    4. XM_030246258.1 → XP_030102118.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X2

      UniProtKB/Swiss-Prot
      A2A4I2, A2A4I3, Q3TLP3, Q3UFY7, Q8BHU9, Q91WE8, Q9D9F9
      Conserved Domains (1) summary
      cd07504
      Location:17 → 289
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    5. XM_017314727.2 → XP_017170216.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X6

      Conserved Domains (1) summary
      pfam05822
      Location:10 → 222
      UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

    6. XM_017314728.1 → XP_017170217.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X6

      Conserved Domains (1) summary
      pfam05822
      Location:10 → 222
      UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

    7. XM_017314726.1 → XP_017170215.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X5

      Conserved Domains (1) summary
      pfam05822
      Location:11 → 256
      UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

    8. XM_017314723.1 → XP_017170212.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X1

      Conserved Domains (1) summary
      cd07504
      Location:25 → 297
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    9. XM_036156925.1 → XP_036012818.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X6

      Conserved Domains (1) summary
      pfam05822
      Location:10 → 222
      UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

    10. XM_017314724.3 → XP_017170213.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X3

      Conserved Domains (1) summary
      cd07504
      Location:12 → 264
      HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

    11. XM_036156928.1 → XP_036012821.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X8

      Conserved Domains (1) summary
      cl21460
      Location:1 → 188
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    12. XM_030246259.1 → XP_030102119.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X6

      Conserved Domains (1) summary
      pfam05822
      Location:10 → 222
      UMPH-1; Pyrimidine 5'-nucleotidase (UMPH-1)

    13. XM_030246261.2 → XP_030102121.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X8

      Conserved Domains (1) summary
      cl21460
      Location:1 → 188
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    14. XM_006534046.5 → XP_006534109.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X8

      See identical proteins and their annotated locations for XP_006534109.1

      Conserved Domains (1) summary
      cl21460
      Location:1 → 188
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    15. XM_030246260.2 → XP_030102120.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X8

      Conserved Domains (1) summary
      cl21460
      Location:1 → 188
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    16. XM_036156927.1 → XP_036012820.1  7-methylguanosine phosphate-specific 5'-nucleotidase isoform X8

      Conserved Domains (1) summary
      cl21460
      Location:1 → 188
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UFY7.3 GenPept UniProtKB/Swiss-Prot:Q3UFY7

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