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    Dynll2 dynein light chain LC8-type 2 [ Mus musculus (house mouse) ]

    Gene ID: 68097, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dynll2provided by MGI
    Official Full Name
    dynein light chain LC8-type 2provided by MGI
    Primary source
    MGI:MGI:1915347
    See related
    Ensembl:ENSMUSG00000020483 AllianceGenome:MGI:1915347
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DLC8; Dlc2; DLC8b; 1700064A15Rik; 6720463E02Rik
    Summary
    Predicted to enable several functions, including dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and scaffold protein binding activity. Predicted to be involved in cilium assembly. Part of cytoplasmic dynein complex and myosin V complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; sensory organ; and thymus primordium. Orthologous to human DYNLL2 (dynein light chain LC8-type 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 107.7), testis adult (RPKM 91.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 C; 11 52.35 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87870351..87892746, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87979525..88003817, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 4 subfamily D member 1 Neighboring gene ubiquitin-conjugating enzyme MHR6BN pseudogene Neighboring gene olfactory receptor enhancer Sifnos Neighboring gene STARR-positive B cell enhancer ABC_E3007 Neighboring gene predicted gene, 38610 Neighboring gene STARR-positive B cell enhancer ABC_E9835 Neighboring gene STARR-seq mESC enhancer starr_30308 Neighboring gene serine and arginine-rich splicing factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The binding of DYNLL2 to myosin Va requires alternatively spliced exon B and stabilizes a portion of the myosin's coiled-coil domain. Wagner W, et al. Biochemistry, 2006 Sep 26. PMID 16981716
    2. Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim. Singh PK, et al. Cell Death Differ, 2020 Feb. PMID 31189926, Free PMC Article
    3. Dynein light chain LC8 regulates syntaphilin-mediated mitochondrial docking in axons. Chen YM, et al. J Neurosci, 2009 Jul 29. PMID 19641106, Free PMC Article
    4. GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity. Moutin E, et al. J Cell Sci, 2012 Apr 15. PMID 22328512
    5. DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. Lin Y, et al. Oncogene, 2010 May 20. PMID 20208559, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim.
      Title: Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim.
    2. GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity.
      Title: GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity.
    3. DLC2-mutant mice display enhanced angiogenic responses.
      Title: DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration.
    4. These data show that alternative splicing of the myosin Va heavy chain controls DYNLL2-myosin Va interaction and that DYNLL2 binding alters the structure of a portion of the myosin's coiled-coil domain.
      Title: The binding of DYNLL2 to myosin Va requires alternatively spliced exon B and stabilizes a portion of the myosin's coiled-coil domain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in 9+0 non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytoplasmic dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of microtubule associated complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin V complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynein light chain 2, cytoplasmic
    Names
    8 kDa dynein light chain b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168471.1 → NP_001161943.1  dynein light chain 2, cytoplasmic

      See identical proteins and their annotated locations for NP_001161943.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK006876, AL604044, AL606805
      Consensus CDS
      CCDS36272.1
      UniProtKB/Swiss-Prot
      A7M7R8, Q3TFB4, Q9D0M5
      UniProtKB/TrEMBL
      Q9D6F6
      Related
      ENSMUSP00000136241.2, ENSMUST00000178105.3
      Conserved Domains (1) summary
      cd21452
      Location:5 → 88
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

    2. NM_001168472.1 → NP_001161944.1  dynein light chain 2, cytoplasmic

      See identical proteins and their annotated locations for NP_001161944.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL606805, BY249698
      Consensus CDS
      CCDS36272.1
      UniProtKB/Swiss-Prot
      A7M7R8, Q3TFB4, Q9D0M5
      UniProtKB/TrEMBL
      Q9D6F6
      Related
      ENSMUSP00000103556.4, ENSMUST00000107923.10
      Conserved Domains (1) summary
      cd21452
      Location:5 → 88
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

    3. NM_026556.4 → NP_080832.1  dynein light chain 2, cytoplasmic

      See identical proteins and their annotated locations for NP_080832.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK078434, AL606805, BY310878
      Consensus CDS
      CCDS36272.1
      UniProtKB/Swiss-Prot
      A7M7R8, Q3TFB4, Q9D0M5
      UniProtKB/TrEMBL
      Q9D6F6
      Related
      ENSMUSP00000020775.3, ENSMUST00000020775.9
      Conserved Domains (1) summary
      cd21452
      Location:5 → 88
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87870351..87892746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246257.2 → XP_030102117.1  dynein light chain 2, cytoplasmic isoform X1

      UniProtKB/Swiss-Prot
      A7M7R8, Q3TFB4, Q9D0M5
      UniProtKB/TrEMBL
      Q9D6F6
      Conserved Domains (1) summary
      cd21452
      Location:5 → 88
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0M5.1 GenPept UniProtKB/Swiss-Prot:Q9D0M5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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