U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Arpc4 actin related protein 2/3 complex, subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 68089, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Arpc4provided by MGI
    Official Full Name
    actin related protein 2/3 complex, subunit 4provided by MGI
    Primary source
    MGI:MGI:1915339
    See related
    Ensembl:ENSMUSG00000079426 AllianceGenome:MGI:1915339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    20kDa; p20-Arc; 5330419I20Rik
    Summary
    Predicted to enable actin filament binding activity and enzyme binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to protein-macromolecule adaptor activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in several cellular components, including actin cytoskeleton; cell projection; and nucleus. Predicted to be part of Arp2/3 protein complex. Is expressed in dorsal root ganglion. Used to study psoriasis. Orthologous to several human genes including ARPC4-TTLL3 (ARPC4-TTLL3 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 58.0), placenta adult (RPKM 48.0) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    6 E3; 6 52.76 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113355074..113367408)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113378113..113390447)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene Neighboring gene transcriptional adaptor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:113327864-113328099 Neighboring gene tubulin tyrosine ligase-like family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1706 Neighboring gene RNA pseudouridylate synthase domain containing 3 Neighboring gene cell death-inducing DFFA-like effector c Neighboring gene predicted gene, 52871

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Active cell migration is critical for steady-state epithelial turnover in the gut. Krndija D, et al. Science, 2019 Aug 16. PMID 31416964
    2. Knockout of the Arp2/3 complex in epidermis causes a psoriasis-like disease hallmarked by hyperactivation of transcription factor Nrf2. van der Kammen R, et al. Development, 2017 Dec 15. PMID 29113991
    3. mTORC1 and mTORC2 Converge on the Arp2/3 Complex to Promote Kras(G12D)-Induced Acinar-to-Ductal Metaplasia and Early Pancreatic Carcinogenesis. Zhao Y, et al. Gastroenterology, 2021 Apr. PMID 33388318
    4. Epithelial colonization by gut dendritic cells promotes their functional diversification. Rivera CA, et al. Immunity, 2022 Jan 11. PMID 34910930, Free PMC Article
    5. Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion. DeMali KA, et al. J Cell Biol, 2002 Dec 9. PMID 12473693, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Arp2/3 protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Arp2/3 protein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    actin-related protein 2/3 complex subunit 4
    Names
    arp2/3 complex 20 kDa subunit

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170485.1 → NP_001163956.1  actin-related protein 2/3 complex subunit 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC155287, AK017993, AK133626
      Consensus CDS
      CCDS51871.1
      UniProtKB/TrEMBL
      E9PWA7
      Related
      ENSMUSP00000131690.2, ENSMUST00000171058.8
      Conserved Domains (1) summary
      cl05433
      Location:2 → 89
      ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)

    2. NM_001170486.1 → NP_001163957.1  actin-related protein 2/3 complex subunit 4 isoform 3

      See identical proteins and their annotated locations for NP_001163957.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC155287, AK017993, AK133626
      Consensus CDS
      CCDS85117.1
      UniProtKB/TrEMBL
      Q3TX55
      Related
      ENSMUSP00000145344.2, ENSMUST00000203578.3
      Conserved Domains (1) summary
      cl05433
      Location:1 → 76
      ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)

    3. NM_026552.3 → NP_080828.1  actin-related protein 2/3 complex subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_080828.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC155287, AK017993, AK133626
      Consensus CDS
      CCDS20417.1
      UniProtKB/Swiss-Prot
      P59999, Q3UWV4
      UniProtKB/TrEMBL
      Q9D3C4
      Related
      ENSMUSP00000114839.2, ENSMUST00000156898.5
      Conserved Domains (1) summary
      pfam05856
      Location:1 → 166
      ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      113355074..113367408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59999.3 GenPept UniProtKB/Swiss-Prot:P59999

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous