Pdzd2 PDZ domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdzd2provided by MGI
Official Full Name: PDZ domain containing 2provided by MGI
Primary source: MGI:MGI:1922394
See related: Ensembl:ENSMUSG00000022197 AllianceGenome:MGI:1922394
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm82; Pdzk3; Gm21706; 4930537L06Rik; A930022H17Rik
Summary: Predicted to be located in several cellular components, including cell-cell junction; centriolar satellite; and postsynaptic density. Is expressed in brain. Orthologous to human PDZD2 (PDZ domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 19.6), subcutaneous fat pad adult (RPKM 4.3) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 5.9 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (12359797..12740052, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (12359711..12739968, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secreted PDZD2 exerts an insulinotropic effect on INS-1E cells by a PKA-dependent mechanism.
Title: Secreted PDZD2 exerts an insulinotropic effect on INS-1E cells by a PKA-dependent mechanism.
Results provide the first evidence that Pdzd2 is required for normal regulation of basal insulin secretion.
Title: Increased basal insulin secretion in Pdzd2-deficient mice.
These findings reveal that Pdzd2 and p11 play collaborative roles in regulation of Na(V)1.8 expression in sensory neurons.
Title: A multi PDZ-domain protein Pdzd2 contributes to functional expression of sensory neuron-specific sodium channel Na(V)1.8.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (3)
Endonuclease-mediated (3)

General gene information

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Markers

D15Mit176 (e-PCR), detects polymorphism
- UniSTS:127547

D15Mit177 (e-PCR), detects polymorphism
- UniSTS:127548

26.MMHAP28FLA5.seq (e-PCR)
- UniSTS:123730

02.MMHAP86FRA8.seq (e-PCR)
- UniSTS:122715

BB060269 (e-PCR)
- UniSTS:186021

NoName (e-PCR)
- UniSTS:237269

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: PDZ domain-containing protein 2

Names: PDZ domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081064.2 → NP_001074533.1 PDZ domain-containing protein 2

See identical proteins and their annotated locations for NP_001074533.1

Status: VALIDATED

Source sequence(s)

AC133282, AC135292, AC150660

Consensus CDS

CCDS37045.1

UniProtKB/TrEMBL

E9Q1M1

Conserved Domains (4) summary

smart00228
Location:2709 → 2791

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1197 → 1562

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1050 → 1355

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:591 → 672

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

12359797..12740052 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520163.5 → XP_006520226.1 PDZ domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006520226.1

UniProtKB/TrEMBL

E9Q1M1

Conserved Domains (4) summary

smart00228
Location:2709 → 2791

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1197 → 1562

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1050 → 1355

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:591 → 672

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006520167.4 → XP_006520230.1 PDZ domain-containing protein 2 isoform X4

Conserved Domains (4) summary

smart00228
Location:2565 → 2647

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1053 → 1418

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:906 → 1211

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:447 → 528

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006520166.4 → XP_006520229.1 PDZ domain-containing protein 2 isoform X3

Conserved Domains (4) summary

smart00228
Location:2617 → 2699

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1105 → 1470

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:958 → 1263

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:499 → 580

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_017316735.3 → XP_017172224.1 PDZ domain-containing protein 2 isoform X7

Conserved Domains (4) summary

smart00228
Location:2378 → 2460

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:866 → 1231

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:719 → 1024

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:260 → 341

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006520165.5 → XP_006520228.1 PDZ domain-containing protein 2 isoform X2

Conserved Domains (4) summary

smart00228
Location:2657 → 2739

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1145 → 1510

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:998 → 1303

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:539 → 620

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006520160.5 → XP_006520223.1 PDZ domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006520223.1

UniProtKB/TrEMBL

E9Q1M1

Conserved Domains (4) summary

smart00228
Location:2709 → 2791

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1197 → 1562

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1050 → 1355

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:591 → 672

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006520161.5 → XP_006520224.1 PDZ domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006520224.1

UniProtKB/TrEMBL

E9Q1M1

Conserved Domains (4) summary

smart00228
Location:2709 → 2791

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1197 → 1562

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1050 → 1355

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:591 → 672

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006520164.3 → XP_006520227.1 PDZ domain-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_006520227.1

UniProtKB/TrEMBL

E9Q1M1

Related

ENSMUSP00000074788.6, ENSMUST00000075317.12

Conserved Domains (4) summary

smart00228
Location:2709 → 2791

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1197 → 1562

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1050 → 1355

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:591 → 672

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_036159557.1 → XP_036015450.1 PDZ domain-containing protein 2 isoform X7

Conserved Domains (4) summary

smart00228
Location:2378 → 2460

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:866 → 1231

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:719 → 1024

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:260 → 341

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006520168.5 → XP_006520231.1 PDZ domain-containing protein 2 isoform X5

See identical proteins and their annotated locations for XP_006520231.1

Conserved Domains (4) summary

smart00228
Location:2535 → 2617

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1023 → 1388

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:876 → 1181

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:417 → 498

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_030248720.2 → XP_030104580.1 PDZ domain-containing protein 2 isoform X6

Conserved Domains (4) summary

smart00228
Location:2391 → 2473

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:879 → 1244

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:732 → 1037

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:273 → 354

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_030248721.2 → XP_030104581.1 PDZ domain-containing protein 2 isoform X7

Conserved Domains (4) summary

smart00228
Location:2378 → 2460

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:866 → 1231

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:719 → 1024

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:260 → 341

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006520169.5 → XP_006520232.1 PDZ domain-containing protein 2 isoform X5

See identical proteins and their annotated locations for XP_006520232.1

Conserved Domains (4) summary

smart00228
Location:2535 → 2617

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1023 → 1388

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:876 → 1181

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:417 → 498

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_030248722.2 → XP_030104582.1 PDZ domain-containing protein 2 isoform X7

Conserved Domains (4) summary

smart00228
Location:2378 → 2460

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:866 → 1231

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:719 → 1024

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:260 → 341

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_017316734.3 → XP_017172223.1 PDZ domain-containing protein 2 isoform X5

Conserved Domains (4) summary

smart00228
Location:2535 → 2617

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03247
Location:1023 → 1388

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:876 → 1181

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:417 → 498

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_036159558.1 → XP_036015451.1 PDZ domain-containing protein 2 isoform X8

UniProtKB/TrEMBL

Q80U45

Conserved Domains (2) summary

smart00228
Location:1431 → 1513

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1303 → 1385

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...