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    Retreg3 reticulophagy regulator family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 67998, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Retreg3provided by MGI
    Official Full Name
    reticulophagy regulator family member 3provided by MGI
    Primary source
    MGI:MGI:1915248
    See related
    Ensembl:ENSMUSG00000017802 AllianceGenome:MGI:1915248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam134c; 1300010M03Rik; 4933404C01Rik
    Summary
    Predicted to be involved in positive regulation of neuron projection development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of protein-containing complex. Is expressed in several structures, including liver; lung; nervous system; nose; and vibrissa. Orthologous to human RETREG3 (reticulophagy regulator family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 37.6), thymus adult (RPKM 37.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 64.2 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100987148..101010720, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101096322..101119841, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7065 Neighboring gene Coenzyme A synthase Neighboring gene STARR-positive B cell enhancer ABC_E11773 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein Neighboring gene MAX-like protein X Neighboring gene STARR-positive B cell enhancer ABC_E4001 Neighboring gene STARR-positive B cell enhancer ABC_E1843 Neighboring gene tubulin, gamma 1 Neighboring gene tubulin, gamma 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy. Di Lorenzo G, et al. Sci Adv, 2022 Sep 2. PMID 36044577, Free PMC Article
    2. Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control. Reggio A, et al. EMBO Rep, 2021 Sep 6. PMID 34338405, Free PMC Article
    3. Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy. Kurth I, et al. Nat Genet, 2009 Nov. PMID 19838196
    4. ¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models. Probert F, et al. J Proteome Res, 2015 May 1. PMID 25849460
    5. ZMPSTE24 defends against influenza and other pathogenic viruses. Fu B, et al. J Exp Med, 2017 Apr 3. PMID 28246125, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endoplasmic reticulum-autophagosome adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within collagen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within reticulophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within reticulophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reticulophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    reticulophagy regulator 3
    Names
    family with sequence similarity 134, member C
    protein FAM134C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361583.1 → NP_001348512.1  reticulophagy regulator 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX255926
      Conserved Domains (1) summary
      pfam02453
      Location:60 → 210
      Reticulon; Reticulon

    2. NM_026501.3 → NP_080777.1  reticulophagy regulator 3 isoform 1

      See identical proteins and their annotated locations for NP_080777.1

      Status: VALIDATED

      Source sequence(s)
      AK004979, AK051025, BX255926
      Consensus CDS
      CCDS25449.1
      UniProtKB/Swiss-Prot
      Q3TQL8, Q3U9Q7, Q8BQC4, Q922X3, Q9CQV4
      Related
      ENSMUSP00000017946.6, ENSMUST00000017946.6
      Conserved Domains (1) summary
      pfam02453
      Location:60 → 210
      Reticulon; Reticulon

    3. NM_028933.4 → NP_083209.1  reticulophagy regulator 3 isoform 2

      See identical proteins and their annotated locations for NP_083209.1

      Status: VALIDATED

      Source sequence(s)
      BX255926
      Consensus CDS
      CCDS25450.1
      UniProtKB/Swiss-Prot
      Q9CQV4
      Related
      ENSMUSP00000102916.4, ENSMUST00000107295.10

    RNA

    1. NR_155070.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK004979, AK016648, AK051025, BX255926

    2. NR_155071.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK004979, AK051025, BX255926, CF726002

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100987148..101010720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156924.1 → XP_036012817.1  reticulophagy regulator 3 isoform X1

      Conserved Domains (1) summary
      cd22562
      Location:41 → 232
      RETR3_RHD; N-terminal reticulon-homology domain of Reticulophagy regulator 3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQV4.1 GenPept UniProtKB/Swiss-Prot:Q9CQV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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