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    Srsf6 serine and arginine-rich splicing factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 67996, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Srsf6provided by MGI
    Official Full Name
    serine and arginine-rich splicing factor 6provided by MGI
    Primary source
    MGI:MGI:1915246
    See related
    Ensembl:ENSMUSG00000016921 AllianceGenome:MGI:1915246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sfrs6; 1210001E11Rik
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 167.2), CNS E11.5 (RPKM 118.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H2; 2 83.87 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (162773428..162779041)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (162931508..162937121)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transcriptional adaptor 3 pseudogene Neighboring gene CDGSH iron sulfur domain 3B Neighboring gene STARR-seq mESC enhancer starr_06291 Neighboring gene STARR-positive B cell enhancer ABC_E7882 Neighboring gene L3MBTL1 histone methyl-lysine binding protein Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX. Wagner AR, et al. Elife, 2022 Nov 21. PMID 36409059, Free PMC Article
    2. The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers. Cohen-Eliav M, et al. J Pathol, 2013 Mar. PMID 23132731
    3. DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing. Li Y, et al. Cell Metab, 2021 Oct 5. PMID 34614409
    4. Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington's disease models. Mason MA, et al. Sci Rep, 2020 Aug 20. PMID 32820193, Free PMC Article
    5. RBM4-Nova1-SRSF6 splicing cascade modulates the development of brown adipocytes. Lin JC, et al. Biochim Biophys Acta, 2016 Nov. PMID 27535496

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX.
      Title: SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX.
    2. DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
      Title: DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
    3. Nova1 isoforms exhibited differential effects on repressing the development of BAs. Moreover, overexpression of Nova1 proteins reduced the serine/arginine splicing factor 6 (SRSF6) level by enhancing the generation of intron 2-included (SRSF6(+intron 2)) transcripts
      Title: RBM4-Nova1-SRSF6 splicing cascade modulates the development of brown adipocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splice site recognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 6
    Names
    pre-mRNA-splicing factor SRP55
    splicing factor, arginine/serine-rich 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026499.4 → NP_080775.3  serine/arginine-rich splicing factor 6

      See identical proteins and their annotated locations for NP_080775.3

      Status: REVIEWED

      Source sequence(s)
      AK133872, AL590418, AL606473, BY783855
      Consensus CDS
      CCDS17002.1
      UniProtKB/Swiss-Prot
      Q3TWW8, Q3UJV5, Q921K3, Q9DBP1
      Related
      ENSMUSP00000119065.2, ENSMUST00000130411.7
      Conserved Domains (2) summary
      cd12766
      Location:110 → 182
      RRM2_SRSF6; RNA recognition motif 2 (RRM2) found found in vertebrate serine/arginine-rich splicing factor 6 (SRSF6)
      cl17169
      Location:1 → 72
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      162773428..162779041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TWW8.1 GenPept UniProtKB/Swiss-Prot:Q3TWW8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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