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    Pold3 polymerase (DNA-directed), delta 3, accessory subunit [ Mus musculus (house mouse) ]

    Gene ID: 67967, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pold3provided by MGI
    Official Full Name
    polymerase (DNA-directed), delta 3, accessory subunitprovided by MGI
    Primary source
    MGI:MGI:1915217
    See related
    Ensembl:ENSMUSG00000030726 AllianceGenome:MGI:1915217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P66; P68; 2410142G14Rik
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to DNA-directed DNA polymerase activity. Involved in DNA biosynthetic process. Part of delta DNA polymerase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human POLD3 (DNA polymerase delta 3, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 18.4), liver E14 (RPKM 17.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pold3 in Genome Data Viewer
    Location:
    7 E2; 7 54.32 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99731317..99770709, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100082110..100121502, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SET translocation pseudogene Neighboring gene chordin-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E3737 Neighboring gene predicted gene, 34760 Neighboring gene STARR-positive B cell enhancer ABC_E11740 Neighboring gene predicted gene, 51452 Neighboring gene lipoyl(octanoyl) transferase 2 (putative)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DNA polymerase delta is required for human mismatch repair in vitro. Longley MJ, et al. J Biol Chem, 1997 Apr 18. PMID 9099749
    2. DNA polymerase delta is involved in the cellular response to UV damage in human cells. Zeng XR, et al. J Biol Chem, 1994 May 13. PMID 7910606
    3. POLD3 Is Haploinsufficient for DNA Replication in Mice. Murga M, et al. Mol Cell, 2016 Sep 1. PMID 27524497, Free PMC Article
    4. Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts. Hughes P, et al. Nucleic Acids Res, 1999 May 15. PMID 10219083, Free PMC Article
    5. Expression of testicular germ cell genes identified by differential display analysis. Anway MD, et al. J Androl, 2003 Mar-Apr. PMID 12634303

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA strand elongation involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA synthesis involved in UV-damage excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in error-prone translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide-excision repair, DNA gap filling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair, DNA gap filling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of delta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of delta DNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of delta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of zeta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase delta subunit 3
    Names
    DNA polymerase delta subunit p66
    GC12
    polymerase (DNA directed), delta 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368380.1 → NP_001355309.1  DNA polymerase delta subunit 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161205
      UniProtKB/Swiss-Prot
      Q9EQ28
      UniProtKB/TrEMBL
      Q3THQ7

    2. NM_133692.2 → NP_598453.1  DNA polymerase delta subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_598453.1

      Status: VALIDATED

      Source sequence(s)
      AK031778
      Consensus CDS
      CCDS21493.1
      UniProtKB/TrEMBL
      Q3THQ7, Q8BH76
      Related
      ENSMUSP00000032969.8, ENSMUST00000032969.14
      Conserved Domains (2) summary
      pfam09507
      Location:19 → 461
      CDC27; DNA polymerase subunit Cdc27
      cl04813
      Location:243 → 340
      EIN3; Ethylene insensitive 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      99731317..99770709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242944.2 → XP_030098804.1  DNA polymerase delta subunit 3 isoform X3

      UniProtKB/TrEMBL
      Q3TS65
      Conserved Domains (1) summary
      pfam09507
      Location:6 → 272
      CDC27; DNA polymerase subunit Cdc27

    2. XM_006508150.5 → XP_006508213.1  DNA polymerase delta subunit 3 isoform X1

      UniProtKB/TrEMBL
      Q3THQ7
      Conserved Domains (1) summary
      pfam09507
      Location:1 → 423
      CDC27; DNA polymerase subunit Cdc27

    3. XM_030242943.2 → XP_030098803.1  DNA polymerase delta subunit 3 isoform X2

      UniProtKB/TrEMBL
      A0A140LHY7, Q3THQ7
      Related
      ENSMUSP00000146603.2, ENSMUST00000208670.2
      Conserved Domains (1) summary
      pfam09507
      Location:1 → 422
      CDC27; DNA polymerase subunit Cdc27
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQ28.2 GenPept UniProtKB/Swiss-Prot:Q9EQ28

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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