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    Cmc1 C-X9-C motif containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 67899, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cmc1provided by MGI
    Official Full Name
    C-X9-C motif containing 1provided by MGI
    Primary source
    MGI:MGI:1915149
    See related
    Ensembl:ENSMUSG00000039163 AllianceGenome:MGI:1915149
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010110K16Rik; 2010312P05Rik
    Summary
    Predicted to enable metal ion binding activity. Located in mitochondrion. Orthologous to human CMC1 (C-X9-C motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.5), bladder adult (RPKM 5.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F3; 9 69.87 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (117893051..117979264, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (118063983..118150196, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif, single stranded interacting protein Neighboring gene predicted gene, 26614 Neighboring gene STARR-seq mESC enhancer starr_25450 Neighboring gene predicted gene, 50606 Neighboring gene STARR-positive B cell enhancer ABC_E3864 Neighboring gene STARR-positive B cell enhancer ABC_E2921 Neighboring gene STARR-positive B cell enhancer mm9_chr9:117962449-117962749 Neighboring gene zinc finger, CW type with PWWP domain 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118059288-118059397 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118105829-118106030 Neighboring gene 5-azacytidine induced gene 2 Neighboring gene predicted gene, 17399 Neighboring gene predicted gene, 53195

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo. O'Brien R, et al. J Biol Chem, 2015 Jul 31. PMID 26025364, Free PMC Article
    2. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. Kaltenbach LS, et al. PLoS Genet, 2007 May 11. PMID 17500595, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COX assembly mitochondrial protein homolog
    Names
    COX assembly mitochondrial protein 1
    cmc1p

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026442.3 → NP_080718.1  COX assembly mitochondrial protein homolog

      See identical proteins and their annotated locations for NP_080718.1

      Status: VALIDATED

      Source sequence(s)
      AC157475, AK020626, CJ170455
      Consensus CDS
      CCDS40800.1
      UniProtKB/Swiss-Prot
      Q6PH95, Q80ZR0, Q9CPZ8
      Related
      ENSMUSP00000047904.10, ENSMUST00000044220.11
      Conserved Domains (1) summary
      pfam08583
      Location:19 → 87
      Cmc1; Cytochrome c oxidase biogenesis protein Cmc1 like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      117893051..117979264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155219.1 → XP_036011112.1  COX assembly mitochondrial protein homolog isoform X1

      Conserved Domains (1) summary
      pfam08583
      Location:15 → 83
      Cmc1; Cytochrome c oxidase biogenesis protein Cmc1 like

    2. XM_011242996.4 → XP_011241298.1  COX assembly mitochondrial protein homolog isoform X1

      Conserved Domains (1) summary
      pfam08583
      Location:15 → 83
      Cmc1; Cytochrome c oxidase biogenesis protein Cmc1 like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPZ8.1 GenPept UniProtKB/Swiss-Prot:Q9CPZ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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